Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders [0.03%]
基于氨基酸神经递质系统的新兴治疗手段：情感障碍药物研发管线的最新进展
Julia Hecking,Pasha A Davoudian,Samuel T Wilkinson
Julia Hecking
Mood disorders represent a pressing public health issue and significant source of disability throughout the world. The classical monoamine hypothesis, while useful in developing improved understanding and clinical treatments, has not fully ...
(Re)contextualizing the Trauma to Prevent or Treat PTSD-Related Hypermnesia [0.03%]
contextualizing创伤以预防或治疗PTSD相关性超忆症
Aline Desmedt
Aline Desmedt
A cardinal feature of Post-traumatic stress-related disorder (PTSD) is a paradoxical memory alteration including both intrusive emotional hypermnesia and declarative/contextual amnesia. Most preclinical, but also numerous clinical, studies ...
Cannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study [0.03%]
大麻素受体1基因多态性、儿童虐待及创伤后应激障碍症状异质性：来自退伍军人健康与复原力研究结果
Nachshon Korem,Or Duek,Ke Xu et al.
Nachshon Korem et al.
Background: Accumulating evidence implicates the endocannabinoid system, including variants in the cannabinoid-1 receptor gene (CNR1), in the pathophysiology of posttraumatic stress disorder (PTSD). The synonymous G1359A ...
Stress Markers for Mental States and Biotypes of Depression and Anxiety: A Scoping Review and Preliminary Illustrative Analysis [0.03%]
抑郁症和焦虑症精神状态和生物类型的应激标志物：系统综述及初步说明性分析
Megan Chesnut,Sahar Harati,Pablo Paredes et al.
Megan Chesnut et al.
Depression and anxiety disrupt daily function and their effects can be long-lasting and devastating, yet there are no established physiological indicators that can be used to predict onset, diagnose, or target treatments. In this review, we...
Task-Modulated Brain Activity Predicts Antidepressant Responses of Prefrontal Repetitive Transcranial Magnetic Stimulation: A Randomized Sham-Control Study [0.03%]
任务调制脑活动预测前额叶重复经颅磁刺激抗抑郁效应：一项随机假刺激对照研究
Cheng-Ta Li,Chih-Ming Cheng,Chi-Hung Juan et al.
Cheng-Ta Li et al.
Background: Prolonged intermittent theta-burst stimulation (piTBS) and repetitive transcranial magnetic stimulation (rTMS) are effective antidepressant interventions for major depressive disorder (MDD). Cognition-modulate...
The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli? [0.03%]
奖赏系统与创伤后应激障碍：创伤会如何影响我们对积极刺激的反应？
Rebecca Seidemann,Or Duek,Ruonan Jia et al.
Rebecca Seidemann et al.
Post-traumatic stress disorder (PTSD) is a highly prevalent disorder and a highly debilitating condition. Although anhedonia is an important construct of the disorder, the relationship between PTSD and reward functioning is still under-rese...
Equine-Assisted Activities and Therapies for Veterans With Posttraumatic Stress Disorder: Current State, Challenges and Future Directions [0.03%]
辅助马术活动和疗法治愈患有创伤后应激障碍的老兵：现状、挑战与未来方向
William R Marchand,Sarah J Andersen,Judy E Smith et al.
William R Marchand et al.
Posttraumatic stress disorder is common among military Veterans. While effective treatments exist, many Veterans either do not engage in treatment or fail to achieve full remission. Thus, there is a need to develop adjunctive complementary ...
The Relative Effects of Prazosin on Individual PTSD Symptoms: Evidence for Pathophysiologically-Related Clustering [0.03%]
氯丙嗪对个体PTSD症状的相对影响：病理生理相关聚类的证据
Rebecca C Hendrickson,Steven P Millard,Kathleen F Pagulayan et al.
Rebecca C Hendrickson et al.
Background: The α1-adrenoreceptor antagonist prazosin has in many but not all studies been found to be effective for PTSD associated nightmares, hyperarousal symptoms, and total symptom severity. The particular efficacy ...
Clara Liao,Alex C Kwan
Clara Liao
Rodent models are an invaluable tool for studying the pathophysiological mechanisms underlying stress and depressive disorders. However, the widely used behavioral assays to measure depressive-like states in rodents have serious limitations...