The Landscape of High-Containment Biological Laboratories in Brazil: Current Status and Perspectives [0.03%]
巴西高 containment 生物实验室的现状与展望
André de Oliveira Mendonça,Claudio Mafra
André de Oliveira Mendonça
Introduction: High-containment biological laboratories (HCBLs) are specialized facilities designed for handling high-risk biological agents. The lack of data regarding the quantity, condition, and distribution of these la...
Decontamination Validation of the BSL-4 Chemical Disinfectant Deluge Shower System [0.03%]
BSL-4化学淋浴消毒系统除污染验证研究
Anders Leung,Todd Cutts,Jay Krishnan
Anders Leung
Introduction: Positive pressure breathing-air-fed protective suits are used in biosafety level 4 (BSL-4) containment laboratories as personal protective equipment to protect workers from high-consequence pathogens. Howeve...
Determining the Efficacy of Chemicals for the Inactivation of Liquid Waste Containing Gram-Positive Bacteria of Risk Group 2 [0.03%]
鉴定化学品灭活含危险组别第二类革兰氏阳性菌液体废物效力的方法研究
Jérémy Rotzetter,Ngoc Dung Le,Flurina L Leib et al.
Jérémy Rotzetter et al.
Background: Inactivation of infectious liquid waste can be performed by different means, including autoclaving or chemical inactivation. Autoclaving is most widely used, but cannot always be implemented, so that chemical ...
A Review of Clinical Trials Involving Genetically Modified Bacteria, Bacteriophages and Their Associated Risk Assessments [0.03%]
基因工程菌、噬菌体的临床研究及其风险评估综述
Paul Gulig,Scott Swindle,Mark Fields et al.
Paul Gulig et al.
Introduction: Discussion of gene-modified investigational products (IPs) in clinical trials has largely focused on nucleic acid-based vectors, viral vectors, and gene-modified cellular products involving mammalian cells. ...
Amanda Brady,Maggie Tomaszewski,Taylor M Garrison et al.
Amanda Brady et al.
Introduction: Yersinia pestis is the gram-negative, facultative intracellular bacterium that causes the disease known as plague. Due to the risk for aerosol transmission, a low infectious dose, and the acute and lethal na...
Chlorine Dioxide Dry Gas: A Promising Solution for Effective Decontamination of Cephalosporin Compounds [0.03%]
二氧化氯干气：有效去污染头孢类化合物的前景解决方案
Rhys Tancock-Jones,Brett Cole,Jeremy Martens et al.
Rhys Tancock-Jones et al.
Introduction: Cephalosporins can trigger hypersensitivity reactions in certain individuals. Consequently, strict regulations restrict the production of non-beta-lactam substances during or after cephalosporin manufacturin...
Nicole E Wheeler,Craig Bartling,Sarah R Carter et al.
Nicole E Wheeler et al.
Objective: DNA synthesis companies screen orders to detect controlled sequences with misuse risks. Assessing screening accuracy is challenging owing to the breadth of biological risks and ambiguities in risk definitions. ...
Substitution Attacks: A Catalyst to Reframe the DNA Manufacturing Cyberbiosecurity Landscape in the Age of Benchtop Synthesizers [0.03%]
替代攻击：在台式合成仪时代重塑DNA制造网络生物安全格局的催化剂
Laura Adam,George H McArthur th
Laura Adam
Background: The advent of easy-to-use benchtop DNA synthesizers has ushered in a transformative era in biotechnology, extending the capabilities of DNA synthesis to nonspecialists. However, this revolution in access to th...
Piers D Millett
Piers D Millett
Introduction: Tools to screen orders submitted to companies synthesizing nucleic acids or machines that can synthesize them are vital to help ensure the building blocks for pathogens, toxins, or other biotechnology that c...
A Sensitivity Study for Interpreting Nucleic Acid Sequence Screening Regulatory and Guidance Documentation: Toward a Foundational Synthetic Nucleic Acid Sequence Screening Framework [0.03%]
核酸序列筛查监管和指导文件解读敏感性研究：迈向基础合成核酸序列筛查框架
Bryan T Gemler,Chiranjit Mukherjee,Patrick A Fullerton et al.
Bryan T Gemler et al.
Objectives: The primary objectives of this study were to develop an objective nucleic acid sequence screening framework and to leverage the framework for an empirical sensitivity study that measures the impact of ambiguit...