Diagnostic Utility of Pre-Genomic Hepatitis B RNA in the Evaluation of HBV/HIV Coinfection [0.03%]
HBV/HIV共感染评估中HBV前基因组RNA检测的诊断价值分析
Kenneth E Sherman,Susan D Rouster,Heidi Meeds et al.
Kenneth E Sherman et al.
Background: Newer biomarkers of Hepatitis B virus (HBV) infection and treatment response have not been well-characterized in individuals with HBV/HIV coinfection. ...
A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis [0.03%]
预测治疗耐药结核病期间利奈唑胺相关神经病变的转录组生物标志物
Nika Zielinski,Dragos Baiceanu,Antonela Dragomir et al.
Nika Zielinski et al.
Background: Neuropathic adverse events occur frequently in linezolid-containing regimens, some of which remain irreversible after drug discontinuation. Ob...
Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2 [0.03%]
针对SARS-CoV-2 N末端结构域的感染增强型抗体的特性与功能
Ruth I Connor,Mrunal Sakharkar,C Garrett Rappazzo et al.
Ruth I Connor et al.
Background: Fcγ-receptor (FcγR)-independent enhancement of SARS-CoV-2 infection mediated by N-terminal domain (NTD)-binding monoclonal antibodies (mAbs) has been observed in vitro, but the functional significance of the...
The Gut and the Translocated Microbiomes in HIV Infection: Current Concepts and Future Avenues [0.03%]
HIV感染中的肠道及易位菌群：当前概念与未来前景
Krystelle Nganou-Makamdop,Daniel C Douek
Krystelle Nganou-Makamdop
It is widely acknowledged that HIV infection results in disruption of the gut's mucosal integrity partly due a profound loss of gastrointestinal CD4+ T cells that are targets of the virus. In addition, systemic inflammation and immune activ...
Evaluation of an Automated Wall-mounted Far Ultraviolet-C Light Technology for Continuous or Intermittent Decontamination of Candida auris on Surfaces [0.03%]
评估自动壁挂式远紫外线C技术在表面连续或间歇消毒白色念珠菌方面的效果
Samir Memic,Claire E Kaple,Jennifer L Cadnum et al.
Samir Memic et al.
Background: Technologies that provides safe and effective decontamination of surfaces and equipment between episodes of manual cleaning could be an important advance in efforts to prevent transmission of the emerging fungal p...
Interview with Drew Weissman, 2023 Nobel Laureate in Physiology or Medicine [0.03%]
2023年诺贝尔生理学或医学奖得主德鲁·韦斯曼访谈
Michael M Lederman,Neil S Greenspan
Michael M Lederman
Invasive and Non-invasive Clinical Haemophilus influenzae Type A Isolates Activate Differentiated HL-60 Cells In Vitro [0.03%]
侵袭性与非侵袭性流感嗜血杆菌A型菌株在体外对分化的HL-60细胞的激活作用不同
Courtney L Ferris,Marina Ulanova
Courtney L Ferris
Background: The effective elimination of encapsulated bacteria like Haemophilus influenzae type a (Hia) relies on immune mechanisms such as complement-mediated opsonophagocytosis by neutrophils in coordination with opsoni...
Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells [0.03%]
PKC调节剂HIV潜伏反转药物对自然杀伤细胞的影响定义
Melanie Dimapasoc,Jose A Moran,Steve W Cole et al.
Melanie Dimapasoc et al.
Background: Latency reversing agents (LRAs) such as protein kinase C (PKC) modulators can reduce rebound-competent HIV reservoirs in small animal models. Furthermore, administration of natural killer (NK) cells following ...
Safety, Efficacy, and Pharmacokinetics of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies BMS-986414 (C135-LS) and BMS-986413 (C144-LS) Administered Subcutaneously in Non-Hospitalized Persons with COVID-19 in a Phase 2 Trial [0.03%]
BMS-986414(C135-LS)和BMS-986413(C144-LS)皮下给药联合治疗非住院COVID-19患者的2期临床试验的安全性、有效性和药代动力学特征
Katya C Corado,Kara W Chew,Mark J Giganti et al.
Katya C Corado et al.
Background: Outpatient COVID-19 monoclonal antibody (mAb) treatment via subcutaneous delivery, if effective, overcomes the logistical burdens of intravenous administration. ...
Harnessing Bacterial Extracellular Vesicle Immune Effects for Cancer Therapy [0.03%]
利用细菌外泌体的免疫效应进行癌症治疗
Irem Karaman,Asmita Pathak,Defne Bayik et al.
Irem Karaman et al.
There are a growing number of studies linking the composition of the human microbiome to disease states and treatment responses, especially in the context of cancer. This has raised significant interest in developing microbes and microbial ...