Leonid B Margolis,Yoel Sadovsky
Leonid B Margolis
The science of extracellular vesicles (EVs) is a rapidly growing field that spans multiple aspects of normal physiology and pathophysiology. EVs play a critical role in most basic biological processes of cell-cell communications under norma...
A Refined Human Linear B Cell Epitope Map of Outer Surface Protein C (OspC) From the Lyme Disease Spirochete, Borrelia Burgdorferi [0.03%]
来自lyme病螺旋体性勃起障碍的外源性表面蛋白C(OspC)的人类线性B细胞精细表位图谱
Grace Freeman-Gallant,Kathleen McCarthy,Jennifer Yates et al.
Grace Freeman-Gallant et al.
Background: A detailed understanding of the human antibody response to outer surface protein C (OspC) of Borrelia burgdorferi has important implications for Lyme disease diagnostics and vaccines. ...
Plasma mcfDNA Sequencing May Improve Usual Care Diagnostics to Detect HHV-8 Among Outpatient People with Advanced HIV [0.03%]
血浆mcfDNA测序可能改善常规护理诊断以检测晚期HIV门诊患者中的HHV-8病毒感染
Sarah Y Park,Brian Epling,Morgan Richey et al.
Sarah Y Park et al.
Background: Human herpesvirus-8 (HHV-8), or Kaposi sarcoma (KS)-associated herpesvirus (KSHV), causes severe disease in people with profound immunosuppression. Yet, diagnosing KS can be challenging given the diverse manif...
Hypervirulent Klebsiella pneumoniae (hv Kp): Overview, Epidemiology, and Laboratory Detection [0.03%]
高毒力肺炎克雷伯菌（hvKP）的概述、流行病学和实验室检测方法
Dania Al Ismail,Edgar I Campos-Madueno,Valentina Donà et al.
Dania Al Ismail et al.
Klebsiella pneumoniae (Kp) is a Gram-negative pathogen responsible for both hospital- and community-acquired infections. Kp is classified into 2 distinct pathotypes: classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (hvKp). Firs...
The TB27 Transcriptomic Model for Predicting Mycobacterium tuberculosis Culture Conversion [0.03%]
TB27转录组模型预测结核分枝杆菌培养阴转的研究
Maja Reimann,Korkut Avsar,Andrew R DiNardo et al.
Maja Reimann et al.
Rationale: Treatment monitoring of tuberculosis patients is complicated by a slow growth rate of Mycobacterium tuberculosis. Recently, host RNA signatures have been used to monitor the response to tuberculosis treatment. ...
Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity [0.03%]
趋化因子的增多是恒河猴自然杀伤细胞介导高效抗HIV包膜特异性抗体依赖的细胞毒性的一个标志
Junsuke Nohara,Tyler Evangelous,Madison Berry et al.
Junsuke Nohara et al.
Background: Antibody-dependent cell-mediated cytotoxic (ADCC) response mediated by natural killer (NK) cells correlates with decreased infection risk in studies involving simian immunodeficiency virus (SIV)/simian-human i...
Inflammation and Microbial Translocation Correlate with Reduced MAIT Cells in People with HIV [0.03%]
HIV患者中炎症和微生物易位与MAIT细胞减少相关
Angela Ryu,Brian M Clagett,Michael L Freeman
Angela Ryu
Background: Optimal control of microbial infections requires mucosal-associated invariant T (MAIT) cells. People living with HIV (PWH) on antiretroviral therapy (ART) can be divided into 2 groups: immune responders (IR) w...
Historical Highlight: The Luria-Delbrück Fluctuation Test - A Study of the Nature of Bacterial Mutations Conferring Resistance to Infection by Bacteriophage [0.03%]
历史回顾：卢里亚-德尔布吕克波动实验——关于赋予细菌抗噬菌体感染性的突变本质的研究
Neil S Greenspan,Emily N Kukan
Neil S Greenspan
Escape of SARS-CoV-2 Variants KP.1.1, LB.1, and KP3.3 From Approved Monoclonal Antibodies [0.03%]
SARS-CoV-2 变体 KP.1.1、LB.1 和 KP3.3 逃逸 approved 单克隆抗体治疗
Delphine Planas,Isabelle Staropoli,Cyril Planchais et al.
Delphine Planas et al.
Background: First-generation anti-SARS-CoV-2 monoclonal antibodies (mAbs) used for prophylaxis or therapeutic purposes in immunocompromised patients have been withdrawn because of the emergence of resistant Omicron varian...
Jonathan Yewdell Discusses Viral Immunology, Vaccine Development, Navigating a Scientific Career, and Offers Perspectives on Transforming Scientific Publishing and Research Education [0.03%]
乔纳森·耶韦德尔论病毒免疫学、疫苗研发、科研职业发展以及关于转化科学出版物和科研教育的观点
Neil S Greenspan
Neil S Greenspan
In this interview, Jonathan Yewdell talks with Pathogens and Immunity senior editor Neil Green-span about the evolution of viral immunology, highlighting his work and the contributions of other influential scientists. He emphasizes the impo...