Jak Inhibitors Modulate Production of Replication-Competent Zika Virus in Human Hofbauer, Trophoblasts, and Neuroblastoma cells [0.03%]
JAK抑制剂可调节人胎盘巨噬细胞样间质细胞和神经母细胞瘤细胞中具有复制能力的寨卡病毒的产生
Christina Gavegnano,Leda C Bassit,Bryan D Cox et al.
Christina Gavegnano et al.
Zika Virus (ZIKV) is a flavivirus that has been implicated in causing brain deformations, birth defects, and microcephaly in fetuses, and associated with Guillain-Barre syndrome. Mechanisms responsible for transmission of ZIKV across the pl...
Varicella Zoster Virus and Large Vessel Vasculitis, the Absence of an Association [0.03%]
水痘带状疱疹病毒与大血管炎无相关性证据
Gary W Procop,Charis Eng,Alison Clifford et al.
Gary W Procop et al.
Objective: It is controversial whether microorganisms play a role in the pathogenesis of large and medium vessel vasculitides (eg, giant cell arteritis [GCA], Takayasu arteritis [TAK] and focal idiopathic aortitis [FIA])....
Kiera L Clayton,J Victor Garcia,Janice E Clements et al.
Kiera L Clayton et al.
Although CD4+ T cells represent the major reservoir of persistent HIV and SIV infection, accumulating evidence suggests that macrophages also contribute. However, investigations of the role of macrophages are often underrepresented at HIV p...
Immunologic Effects of Maraviroc in HIV-Infected Patients with Severe CD4 Lymphopenia Starting Antiretroviral Therapy: A Sub-Study of the CADIRIS Trial [0.03%]
马拉韦罗对卡迪里斯试验中开始抗逆转录病毒治疗且CD4淋巴细胞严重缺乏的HIV感染者免疫学效应的亚研究
Pablo F Belaunzarán-Zamudio,Livio Azzoni,David H Canaday et al.
Pablo F Belaunzarán-Zamudio et al.
Background: We aimed to describe the mechanisms of immunological recovery and the effects of blocking CCR5 in patients starting ART with advanced HIV-infection. ...
Claudia Alvarado-de la Barrera,Gustavo Reyes-Terán
Claudia Alvarado-de la Barrera
As a consequence of late presentation for HIV care, a significant proportion of individuals develop immune reconstitution inflammatory syndrome (IRIS) soon after initiation of antiretroviral therapy. Incidence, predictors, and models of pat...
Association of Anisocytosis with Markers of Immune Activation and Exhaustion in Treated HIV [0.03%]
红细胞异形症与治疗HIV患者免疫活化和耗竭标志物的相关性研究
Sadeer G Al-Kindi,David A Zidar,Grace A McComsey et al.
Sadeer G Al-Kindi et al.
Background: Treated HIV infection is associated with heightened inflammation which can contribute to increased risk of cardiovascular disease (CVD). We have previously shown that anisocytosis, as measured by red cell dist...
Hurdles to the Development of Effective HBV Immunotherapies and HCV Vaccines [0.03%]
乙型肝炎免疫疗法及丙型肝炎疫苗开发的障碍
Almudena Torres-Cornejo,Georg M Lauer
Almudena Torres-Cornejo
Chronic infections with HBV and HCV continue to be major public health problems, with hundreds of millions of people infected worldwide; this is despite the availability of both an effective prophylactic HBV vaccine for more than 3 decades ...
Socioeconomic Determinants of Cipro-floxacin-Resistant Shigella Infections in Bangladeshi Children [0.03%]
孟加拉国儿童环丙沙星耐药性志贺菌感染的社会经济决定因素
Randon J Gruninger,Russell A Johnson,Sumon K Das et al.
Randon J Gruninger et al.
Background: Shigella species (spp.) are a leading cause of moderate to severe diarrhea in children worldwide. The recent emergence of quinolone-resistant Shigella spp. gives cause for concern, and South Asia has been iden...
Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection [0.03%]
经治HIV感染人群的乙肝疫苗应答与较低基线生发中心活性和保存的Th1免疫有关
Robert M Paris,Lucimar G Milagres,Eirini Moysi et al.
Robert M Paris et al.
Background: Why HIV-infected individuals have poor responses to standard dose and schedule hepatitis B virus immunization is not well understood. Methods:...
Celebrating More Than a Century of Research on Antibodies: Affirmation Through Negation via Complex Formation [0.03%]
庆祝关于抗体的研究超过一个世纪：通过复合物形成否定来肯定
Neil S Greenspan
Neil S Greenspan
In this brief commentary, I highlight the remarkable properties of antibodies (also known as immunoglobulins) revealed by more than 100 years of biomedical research. Since antibodies can be elicited through one or another means against almo...