Sensitizing Clostridium difficile Spores with Germinants on Skin and Environmental Surfaces Represents a New Strategy for Reducing Spores via Ambient Mechanisms [0.03%]
用促发剂活化皮肤和环境表面的艰难梭菌孢子代表了一种通过环境机制减少孢子的新策略
Michelle M Nerandzic,Curtis J Donskey
Michelle M Nerandzic
Background: Clostridium difficile is a leading cause of healthcare-associated infections worldwide. Prevention of C. difficile transmission is challenging because spores are not killed by alcohol-based hand sanitizers or ...
Prospective Analysis of Lipid Composition Changes with Antiretroviral Therapy and Immune Activation in Persons Living with HIV [0.03%]
抗逆转录病毒治疗与人类免疫缺陷病毒感染者的血脂组成变化和免疫活化的关系研究
Martha A Belury,Emily Bowman,Janelle Gabriel et al.
Martha A Belury et al.
Background: Lipid profiles are altered by HIV infection and antiretroviral therapy (ART). Among HIV-uninfected (HIV-) populations the concentrations of various lipid classes (ie, lyso-phosphatidylcholine, LPC) and their s...
Direct-Acting Antivirals in Kidney Transplant Patients: Successful Hepatitis C Treatment and Short-Term Reduction in Urinary Protein/Creatinine Ratios [0.03%]
直接抗病毒药物治疗肾移植受者的丙肝及其对蛋白尿的影响
Michael R Goetsch,Ashutosh Tamhane,Mohit Varshney et al.
Michael R Goetsch et al.
Background: The role of Hepatitis C Virus (HCV) clearance in kidney graft survival is unknown. We examined short-term trends of protein/creatinine (P/C) ratios in HCV-infected kidney transplant recipients treated with dir...
Henry Friedman,Nancy Ator,Nancy Haigwood et al.
Henry Friedman et al.
The sponsors of this report endorse carefully regulated research with nonhuman primates. This research is essential to learning about the biology, treatment and prevention of diseases and conditions that cause human suffering. ...
A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals [0.03%]
雷米普利用于减少接受抗逆转录病毒治疗的人类免疫缺陷病毒感染者淋巴组织纤维化随机对照试验
Leslie R Cockerham,Steven A Yukl,Kara Harvill et al.
Leslie R Cockerham et al.
Background: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to an...
Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo [0.03%]
氯化十四培酰吡啶(CPC)具有抗流感病毒的体内外广谱快速杀灭活性
Daniel L Popkin,Sarah Zilka,Matthew Dimaano et al.
Daniel L Popkin et al.
Background: There is a continued need for strategies to prevent influenza. While cetylpyridinium chloride (CPC), a broad-spectrum antimicrobial agent, has an extensive antimicrobial spectrum, its ability to affect respira...
CD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells [0.03%]
接受抗逆转录病毒治疗后仍不能恢复CD4+T细胞的HIV感染者中粘膜相关不变天然杀伤性T细胞表面表达的CD161降低
Michael L Freeman,Stephen R Morris,Michael M Lederman
Michael L Freeman
Background: Mucosa-associated invariant T (MAIT) cells are a recently identified class of innate-like T cells that are involved in the mucosal immune response. MAIT cells are characterized by expression of TCR Vα7.2 and ...
T-cell Responses in Individuals Infected with Zika Virus and in Those Vaccinated Against Dengue Virus [0.03%]
寨卡病毒感染者和登革热疫苗接种者中的T细胞反应情况
Dominic Paquin-Proulx,Fabio E Leal,Cassia G Terrassani Silveira et al.
Dominic Paquin-Proulx et al.
Background: The outbreak of Zika virus (ZIKV) infection in Brazil has raised concerns that infection during pregnancy could cause microcephaly and other severe neurodevelopmental malformations in the fetus. The mechanisms...
Never Let a Crisis Go to Waste: Recruiting the Next Generation of Infectious Diseases Physicians [0.03%]
危机之时 铸剑之刻——培养下一代传染病医师
Curtis J Donskey
Curtis J Donskey
Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection [0.03%]
循环LOXL2水平反映HIV感染治疗的肠纤维化严重程度和GALT中CD4+T淋巴细胞耗竭
Sophie Seang,Anoma Somasunderam,Maitreyee Nigalye et al.
Sophie Seang et al.
Background: Incomplete immune reconstitution may occur despite successful antiretroviral therapy (ART). Gut-associated lymphoid tissue (GALT) fibrosis may contribute via local CD4+ T lymphocyte depletion, intestinal barri...