Arturo Casadevall
Arturo Casadevall
Fungal diseases became a major medical problem in the second half of the 20th century when advances in modern medicine together with the HIV epidemic resulted in large numbers of individuals with impaired immunity. Fungal diseases are diffi...
Soluble Markers of Immune Activation Differentially Normalize and Selectively Associate with Improvement in AST, ALT, Albumin, and Transient Elastography During IFN-Free HCV Therapy [0.03%]
无干扰素HCV治疗期间可溶性免疫活化标志物分别恢复正常并选择性与AST，ALT，白蛋白和瞬时弹性成像改善相关
Lenche Kostadinova,Carey L Shive,Elizabeth Zebrowski et al.
Lenche Kostadinova et al.
Background: During chronic hepatitis C virus (HCV) infection, Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) levels mark active liver inflammation and tissue damage, while albumin reflects synthetic l...
Fecal Host Transcriptomics for Non-Invasive Human Mucosal Immune Profiling: Proof of Concept in Clostridium Difficile Infection [0.03%]
人粘膜免疫非侵入式检测的粪便宿主转录组学研究：难辨梭菌感染的概念验证
Robert Schlaberg,Amanda Barrett,Kornelia Edes et al.
Robert Schlaberg et al.
Background: Host factors play an important role in pathogenesis and disease outcome in Clostridium difficile infection (CDI), and characterization of these responses could uncover potential host biomarkers to complement e...
Eileen P Scully
Eileen P Scully
Biological sex is a determinant of both susceptibility to and pathogenesis of multiple infections, including HIV. These differences have effects on the spectrum of HIV disease from acquisition to eradication, with diverse mechanisms includi...
Long Non-Coding RNA-Mediated Regulation of the Interferon Response: A New Perspective on a Familiar Theme [0.03%]
长非编码RNA介导的干扰素反应调控：旧主题的新视角
Saba Valadkhan,Leah M Plasek
Saba Valadkhan
The interferon (IFN) response is a critical and ubiquitous component of the innate immune response to pathogens. Detailed studies in the last decades have elucidated the function of a large number of proteins that mediate the complex signal...
Variation in Macrophage Phagocytosis of Streptococcus agalactiae Does Not Reflect Bacterial Capsular Serotype, Multilocus Sequence Type, or Association with Invasive Infection [0.03%]
变异的巨噬细胞对Streptococcus agalactiae的吞噬作用与其细菌荚膜血清型、多位点序列型或与侵袭性感染相关性无关
Lisa M Rogers,Jennifer A Gaddy,Shannon D Manning et al.
Lisa M Rogers et al.
Background: Group B Streptococcus (GBS) is an encapsulated Gram-positive coccus that is an important cause of infections in adults with chronic medical conditions, pregnant women, and neonates. GBS causes a range of clini...
Biomarkers Associated with Death After Initiating Treatment for Tuberculosis and HIV in Patients with Very Low CD4 Cells [0.03%]
低CD4细胞计数的结核病合并艾滋病患者接受治疗后与死亡相关的生物标志物
Fred R Sattler,Daniel Chelliah,Xingye Wu et al.
Fred R Sattler et al.
Background: The risk of short-term death for treatment naive patients dually infected with Mycobacterium tuberculosis and HIV may be reduced by early anti-retroviral therapy. Of those dying, mechanisms responsible for fat...
ADCC-Mediated CD56DIM NK Cell Responses Are Associated with Early HBsAg Clearance in Acute HBV Infection [0.03%]
自然杀伤细胞介导的抗体依赖性细胞介导的细胞毒作用与急性乙肝病毒感染早期HBsAg自发清除相关
Wen-Han Yu,Cormac Cosgrove,Christoph T Berger et al.
Wen-Han Yu et al.
Background: Hepatitis B virus (HBV) affects up to 400 million people worldwide and accounts for approximately one million deaths per year from liver pathologies. Current treatment regimens are effective in suppressing vir...
Impact of HLA Class I Alleles on Timing of HIV Rebound After Antiretroviral Treatment Interruption [0.03%]
人类白细胞抗原I类等位基因对艾滋病病毒抗逆转录病毒治疗中断后反弹时间的影响
You Jeong Park,Behzad Etemad,Hayat Ahmed et al.
You Jeong Park et al.
Background: Identifying host determinants associated with HIV reservoir size and timing of viral rebound after an analytic treatment interruption (ATI) is an important step in the search for an HIV functional cure. We per...
Ten Years HIV Free: An Interview with "The Berlin Patient," Timothy Ray Brown [0.03%]
柏林病人十年无艾滋病病毒：对蒂莫西·雷·布朗的采访
Michael M Lederman,Earl Pike
Michael M Lederman