In Vitro Activity of 3 Commercial Bacteriophage Cocktails Against Salmonella and Shigella spp. Isolates of Human Origin [0.03%]
三种市售噬菌体制剂对人源沙门氏菌和志贺菌的体外活性研究
Odette J Bernasconi,Valentina Donà,Regula Tinguely et al.
Odette J Bernasconi et al.
Background: Salmonella and Shigella spp. are 2 of the most frequent and deadly enteric bacterial pathogens recorded worldwide. In developing countries Salmonella infections are responsible for many deaths annually and the...
Antibiotics-From There to Where?: How the antibiotic miracle is threatened by resistance and a broken market and what we can do about it [0.03%]
抗生素--从过去到未来？抗生素市场如何被耐药性问题和失效的市场机制所威胁，以及我们应当如何应对这一挑战
David M Shlaes,Patricia A Bradford
David M Shlaes
Ziva Weisman,Alexander Kalinkovich,Miguel Stein et al.
Ziva Weisman et al.
Introduction: Helminth infection has a profound effect on the immune system. However, the precise nature of the immune changes that are elicited by helminth infection have not been sufficiently characterized. Furthermore,...
The Immunostimulatory Capacity of Nontypeable Haemophilus influenzae Lipooligosaccharide [0.03%]
非典型流感嗜血杆菌脂寡糖的免疫刺激能力
Gabrielle N Gaultier,Kayla N Colledanchise,Alaa Alhazmi et al.
Gabrielle N Gaultier et al.
Background: We have recently found that lipooligosaccharide (LOS) isolated from encapsulated strains of Haemophilus influenzae (H. influenzae) has strong adjuvant, but diminished pro-inflammatory ability as compared to Es...
Clinical Usefulness of Klebsiella Pneumoniae Carbapenemase-Producing K. Pneumoniae Genotyping: The Experience of a Single-Center Epidemic [0.03%]
碳青霉烯酶克雷伯菌肺炎克雷伯菌基因分型的临床作用：单一中心流行病的经验教训
Marianna Rossi,Liliane Chatenoud,Egidio Franco Viganò et al.
Marianna Rossi et al.
Background: During the last decade, the spread of Klebsiella pneumoniae-carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) has increased dramatically worldwide. In this scenario, growing interest has been addressed to...
Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review [0.03%]
用于HIV-1整合酶抑制剂研究的非人灵长类和人源化小鼠：综述
Said A Hassounah,Thibault Mesplède,Mark A Wainberg
Said A Hassounah
Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy due in part to the high mutation rate of HIV. Therefore, the development of a predictive animal model is important to id...
Increased CMV IgG Antibody Titer is Associated with Non-AIDS Events among Virologically Suppressed HIV-Positive Persons [0.03%]
CMV IgG抗体滴度增加与病毒学抑制的HIV感染者非艾滋病事件相关性研究
Aimee C Hodowanec,Nell S Lurain,Supriya Krishnan et al.
Aimee C Hodowanec et al.
Background: Among HIV-positive individuals, increased levels of inflammation and immune activation persist even in the setting of effective antiretroviral therapy (ART) and are associated with greater rates of non-AIDS ev...
HBV and HIV/HBV Infected Patients Have Distinct Immune Exhaustion and Apoptotic Serum Biomarker Profiles [0.03%]
乙型肝炎病毒和人类免疫缺陷病毒/乙型肝炎病毒共感染患者的免疫耗竭和凋亡的血清生物标志物谱特征不同
Mohamed Tarek M Shata,Enass A Abdel-Hameed,Susan D Rouster et al.
Mohamed Tarek M Shata et al.
Background: Hepatitis B virus (HBV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Due to their shared routes of transmission, approximately 10% of HIV-infected...
Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection [0.03%]
SAMHD1对HIV-1的抑制作用不完全允许高效巨噬细胞感染
Timothy Plitnik,Mark E Sharkey,Bijan Mahboubi et al.
Timothy Plitnik et al.
Background: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are requi...