Four Weeks of Treatment With Rifaximin Fails to Significantly Alter Microbial Diversity in Rectal Samples of HIV-Infected Immune Non-Responders (ACTG A5286) Which May be Attributed to Rectal Swab Use [0.03%]
利福昔敏四周期治疗无法显著改变HIV免疫无应答者直肠样本微生物多样性（ACTG A5286），这可能归因于肛拭子使用性
Brett B Williams,Stefan J Green,Ronald J Bosch et al.
Brett B Williams et al.
Introduction: HIV-infected individuals have evidence of intestinal microbial translocation which is associated with immune activation and unfavorable clinical outcomes. Rifaximin, a non-absorbable antibiotic which reduces...
α-Defensin HD5 Stabilizes Human Papillomavirus 16 Capsid/Core Interactions [0.03%]
人乳头瘤病毒16型衣壳/核心相互作用稳定化
Neetu M Gulati,Masaru Miyagi,Mayim E Wiens et al.
Neetu M Gulati et al.
Background: Human papillomavirus (HPV) is linked to nearly all cases of cervical cancer. Despite available vaccines, a deeper understanding of the immune response to HPV is needed. Human α-defensin 5 (HD5), an innate imm...
Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies: Data from A Real-Life Case-Series [0.03%]
一组抗真菌疗法在血液系统恶性肿瘤儿童患者中治疗侵袭性霉菌感染的临床疗效：真实世界病例系列数据研究
Anna Maria Peri,Marta Verna,Stefano Biffi et al.
Anna Maria Peri et al.
Background: Invasive mold infections in children with hematological malignancies are associated with high mortality rates. The use of combination antifungal therapy in cases with a severe clinical course is increasing, al...
Sex Differences in the Association of Fat and Inflammation Among People with Treated HIV Infection [0.03%]
抗HIV治疗者的脂肪异常与炎症的性别差异
Marcelo Chen,Chung-Lieh Hung,Chun-Ho Yun et al.
Marcelo Chen et al.
Introduction: Ectopic fat deposition may contribute to chronic inflammation in people with HIV (PWH). To provide information for future mechanistic studies of metabolic risk in this population, we sought to determine whic...
CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals [0.03%]
CD32-RNA与HIV-RNA在病毒血症和抗逆转录病毒治疗抑制的个体肠组织中CD3+细胞内的共定位现象
Joshua J Vásquez,Brandon L Aguilar-Rodriguez,Leonardo Rodriguez et al.
Joshua J Vásquez et al.
Background: Identifying biomarkers for cells harboring replication-competent HIV is a major research priority. Recently, there have been mixed reports addressing the possibility that CD32-expressing T cells are enriched f...
Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART [0.03%]
补充抗逆转录病毒治疗的HIV感染者血清牛免疫球蛋白可改善炎症和肠道屏障功能失调病情
Netanya S Utay,Anoma Somasunderam,John E Hinkle et al.
Netanya S Utay et al.
Background: Systemic inflammation persists in chronic HIV infection and is associated with increased rates of non-AIDS events such as cardiovascular and liver disease. Increased gut permeability and systemic exposure to m...
Microbiomes of Inflammatory Thoracic Aortic Aneurysms Due to Giant Cell Arteritis and Clinically Isolated Aortitis Differ From Those of Non-Inflammatory Aneurysms [0.03%]
巨细胞动脉炎和临床孤立性主动脉炎引起的炎症性胸主动脉瘤与非炎症性主动脉瘤的微生物群不同
Ted M Getz,Gary S Hoffman,Roshan Padmanabhan et al.
Ted M Getz et al.
Objective: We sought to characterize microbiomes of thoracic aortas from patients with non-infectious aortitis due to giant cell arteritis (GCA) and clinically isolated aortitis (CIA) and to compare them to non-inflammato...
Relapse Following Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia Apparently Due to Somatic Cell Evolution via Epigenetic Variation and Immune Selection [0.03%]
供者细胞表观遗传变异和免疫选择导致的急性髓系白血病异基因造血干细胞移植后复发
Neil S Greenspan
Neil S Greenspan
In this brief commentary, I discuss a recently published study that documents the role of immune escape in relapse of acute myeloid leukemia (AML) after hematopoietic cell transplantation (HCT). Of particular interest, the mechanism identif...
Gary S Hoffman,Ted M Getz,Roshan Padmanabhan et al.
Gary S Hoffman et al.
Objective: A role for microorganisms in giant cell arteritis (GCA) has long been suspected. We describe the microbiomes of temporal arteries from patients with GCA and controls. ...
Susceptibility to SIV Infection After Adenoviral Vaccination in a Low Dose Rhesus Macaque Challenge Model [0.03%]
低剂量猴挑战模型中腺病毒疫苗接种后的猴免疫缺陷病毒(SIV)感染易感性研究
Irene Bukh Brody,Roberto Calcedo,Mary J Connell et al.
Irene Bukh Brody et al.
Background: Vaccination with the Merck human adenovirus serotype-5 (HAdV-5) vectored HIV-1 subtype B gag/pol/nef vaccine was unexpectedly associated with enhanced susceptibility to HIV-1 infection in uncircumcised HAdV-5 ...