Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva [0.03%]
可通过唾液检测到对SARS-CoV-2信使RNA疫苗的抗体反应
Thomas J Ketas,Devidas Chaturbhuj,Victor M Cruz Portillo et al.
Thomas J Ketas et al.
The approved Pfizer and Moderna mRNA vaccines are well known to induce serum antibody responses to the SARS-CoV-2 Spike (S)-protein. However, their abilities to elicit mucosal immune responses have not been reported. Saliva antibodies repre...
Evaluation of 2 Ultraviolet-C Light Boxes for Decontamination of N95 Respirators [0.03%]
两种紫外线C消毒盒对N95口罩消毒效果的评估
Jennifer L Cadnum,Basya S Pearlmutter,Daniel F Li et al.
Jennifer L Cadnum et al.
Background: Ultraviolet-C (UV-C) light devices are effective in reducing contamination on N95 filtering facepiece respirators. However, limited information is available on whether UV-C devices meet the Food and Drug Admin...
Passive Immunity to Vibrio cholerae O1 Afforded by a Human Monoclonal IgA1 Antibody Expressed in Milk [0.03%]
人源单克隆IgA1抗体通过乳汁提供对霍乱弧菌O1的被动免疫
Danielle E Baranova,Lihow Chen,Margaret Destrempes et al.
Danielle E Baranova et al.
Background: In cholera epidemics, the spread of disease can easily outpace vaccine control measures. The advent of technologies enabling the expression of recombinant proteins, including antibodies, in the milk of transge...
COVID-19 Outcomes in Patients Undergoing B Cell Depletion Therapy and Those with Humoral Immunodeficiency States: A Scoping Review [0.03%]
B细胞耗竭治疗患者的新型冠状病毒肺炎预后及体液免疫缺陷状态患者的预后：系统综述
Jessica M Jones,Aiman J Faruqi,James K Sullivan et al.
Jessica M Jones et al.
Background: The role of humoral immunity has been well established in reducing infection risk and facilitating viral clearance in patients with COVID-19. However, the relationship between specific antibody responses and s...
Plasma Extracellular Vesicle Subtypes May be Useful as Potential Biomarkers of Immune Activation in People With HIV [0.03%]
血浆细胞外囊泡亚型可能可用于HIV感染者免疫激活潜在生物标志物的检测
Wilfried Wenceslas Bazié,Julien Boucher,Julien Vitry et al.
Wilfried Wenceslas Bazié et al.
Background: Extracellular vesicles (EVs) are intercellular messengers with epigenetic potential since they can shuttle microRNA (miRNA). EVs and miRNA play a role in human immunodeficiency virus (HIV) infection immunopath...
Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2 [0.03%]
α1抗胰蛋白酶能抑制SARS-CoV-2辅助受体TMPRSS2
Nurit P Azouz,Andrea M Klingler,Victoria Callahan et al.
Nurit P Azouz et al.
Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversia...
The Intersection of COVID-19 and Autoimmunity: What is Our Current Understanding? [0.03%]
COVID-19与自身免疫的交汇：我们目前的理解是什么？
N Winchester,C Calabrese,L H Calabrese
N Winchester
Viral infections have historically had a complex relationship with autoimmune diseases. For patients with preexisting autoimmune disorders, often complicated by immunosuppressive therapies, there are numerous potential effects of COVID-19, ...
Evaluation of Six Weekly Oral Fecal Microbiota Transplants in People with HIV [0.03%]
HIV患者六周口服粪菌移植评价研究
Netanya S Utay,Ana N Monczor,Anoma Somasunderam et al.
Netanya S Utay et al.
Background: Reduced microbiota diversity (dysbiosis) in people with HIV (PWH) likely contributes to inflammation, a driver of morbidity and mortality. We aimed to evaluate the safety and tolerability of 6 weekly oral feca...
The Effects of Anti-retroviral Therapy on Epigenetic Age Acceleration Observed in HIV-1-infected Adults [0.03%]
抗逆转录病毒治疗对HIV-1感染者表观遗传衰老的影响观测
Mary E Sehl,Tammy M Rickabaugh,Roger Shih et al.
Mary E Sehl et al.
Background: HIV-1 infection is associated with acceleration of age-related methylation patterns in peripheral blood and brain of infected individuals although the relative contributions of HIV-1 infection versus its treat...
Changes in the Serum Metabolome of Patients Treated With Broad-Spectrum Antibiotics [0.03%]
广谱抗生素治疗患者的血清代谢组变化
George E Jaskiw,Mark E Obrenovich,Sirisha Kundrapu et al.
George E Jaskiw et al.
Background: The gut microbiome (GMB) generates numerous small chemicals that can be absorbed by the host and variously biotransformed, incorporated, or excreted. The resulting metabolome can provide information about the ...