Michael M Lederman,Jeffrey S Flier,Peter Hale et al.
Michael M Lederman et al.
On September 10, 2021, a special tribunal established by the French government launched an inquiry into the activities of former health minister Dr. Agnes Buzyn who was charged with "endangering the lives of others". It is surprising to lea...
Soluble Tumor Necrosis Factor Receptor 1 is Associated With Cardiovascular Risk in Persons With Coronary Artery Calcium Score of Zero [0.03%]
冠状动脉钙积分数为零人群中的可溶性肿瘤坏死因子受体1与心血管风险相关
Tony Dong,Graham Bevan,David A Zidar et al.
Tony Dong et al.
Background: A coronary artery calcium (CAC) score of zero confers a low but nonzero risk of atherosclerotic cardiovascular events (CVD) in asymptomatic patient populations, and additional risk stratification is needed to ...
A Patient With Multiple Carbapenemase Producers Including an Unusual Citrobacter sedlakii Hosting an IncC bla NDM-1- and armA-carrying Plasmid [0.03%]
一例多重碳青霉烯酶产生产者的感染病例，包括一种罕见的携带IncC型blaNDM-1和armA阳性质粒的产酸肠杆菌科细菌（Citrobacter sedlakii）感染者
Aline I Moser,Peter M Keller,Edgar I Campos-Madueno et al.
Aline I Moser et al.
Background: Patients colonized with multiple species of carbapenemase-producing Enterobacterales (CPE) are increasingly observed. This phenomenon can be due to the high local prevalence of these pathogens, the presence of...
Impaired Memory B-Cell Response to Influenza Immunization in Patients With Common Variable Immunodeficiency (CVID) [0.03%]
常见变量免疫缺陷(CVID)患者流感疫苗接种后记忆B细胞应答受损
Wei Zhan,Todd Hatchette,Fengyun Yue et al.
Wei Zhan et al.
Background: Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency characterized by low serum antibody levels and recurrent infections. The cellular response to immunization in patients with C...
High Red Cell Distribution Width and Low Absolute Lymphocyte Count Associate With Subsequent Mortality in HCV Infection [0.03%]
红细胞分布宽度高和淋巴细胞绝对计数低与HCV感染后的死亡率相关
Sofi Damjanovska,Perica Davitkov,Surya Gopal et al.
Sofi Damjanovska et al.
Background: Hepatitis-C virus (HCV) chronic infection can lead to cirrhosis, hepatocellular carcinoma (HCC), end-stage liver disease, cardiovascular disease (CVD), and mortality. Transient Elastography (TE) is used to non...
Pre-cART Immune Parameters in People Living With HIV Might Help Predict CD8+ T-Cell Characteristics, Inflammation Levels, and Reservoir Composition After Effective cART [0.03%]
艾滋病毒携带者在接受有效抗逆转录病毒治疗前的免疫参数可能有助于预测接受治疗后的CD8+t细胞特征、炎症水平和储存库组成
Jimena Salido,Alejandro Czernikier,César Trifone et al.
Jimena Salido et al.
Background: Combined antiretroviral treatment (cART) for HIV infection is highly effective in controlling viral replication. However, it cannot achieve a sterilizing cure. Several strategies have been proposed to achieve ...
Michael M Lederman,Neil S Greenspan
Michael M Lederman
Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level [0.03%]
核酸衣壳中R203K/G204R变异引发新型SARS-CoV-2亚基因组RNA生成：同源重组有可能在蛋白和RNA水平改变SARS-CoV-2病毒特性
Shay Leary,Silvana Gaudieri,Matthew D Parker et al.
Shay Leary et al.
Background: Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host's anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we e...
Lack of Atorvastatin Effect on Monocyte Gene Expression and Inflammatory Markers in HIV-1-infected ART-suppressed Individuals at Risk of non-AIDS Comorbidities [0.03%]
阿托伐他汀对HIV-1感染者单核细胞基因表达和炎症标志物的影响较小
Anjana Yadav,Andrew V Kossenkov,Louise C Showe et al.
Anjana Yadav et al.
Background: Many people living with HIV have persistent monocyte activation despite viral suppression by antiretroviral therapy (ART), which contributes to non-AIDS complications including neurocognitive and other disorde...
Molecular Diagnosis of SARS-CoV-2: Assessing and Interpreting Nucleic Acid and Antigen Tests [0.03%]
SARS-CoV-2分子诊断：评估和解读核酸及抗原检测试验
Peter A Zimmerman,Christopher L King,Mahmoud Ghannoum et al.
Peter A Zimmerman et al.
In this review, we summarize the current status of nucleic acid and antigen testing required for diagnosing SARS-CoV-2 infection and COVID-19 disease. Nucleic acid amplification (NAAT) and antigen-detection (Ag) tests occupy a critically im...