An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza [0.03%]
一种ACE2-IgG4融合蛋白可结合所有检测到的SARS-CoV-2变异毒株并减少动物模型中的肺部炎症反应
Emmanuel Y Merigeon,Dong Yang,Elizabeth A Ihms et al.
Emmanuel Y Merigeon et al.
Background: The continued emergence of SARS-CoV-2 variants has caused concern that a constantly evolving virus will escape vaccines and antibody therapies. New approaches are needed. ...
Use of a MAIT-Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination [0.03%]
一种新的黏膜佐剂5-OP-RU通过激活MAIT细胞增强霍乱疫苗效果小鼠模型中的应用研究
Owen Jensen,Shubhanshi Trivedi,Kelin Li et al.
Owen Jensen et al.
Background: Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in the mucosa with capacity for B-cell help. We hypothesize that targeting MAIT cells, using a MAIT-activating ligand as an adjuvant...
Elevated Plasma Soluble ST2 Levels are Associated With Neuronal Injury and Neurocognitive Impairment in Children With Cerebral Malaria [0.03%]
血浆可溶性ST2水平升高与儿童脑疟疾的神经元损伤和神经认知障碍有关
Elizabeth M Fernander,Pontian Adogamhe,Dibyadyuti Datta et al.
Elizabeth M Fernander et al.
Background: Murine experimental cerebral malaria studies suggest both protective and deleterious central nervous system effects from alterations in the interleukin-33 (IL-33)/ST2 pathway. ...
Why Does Doxycycline Pose a Relatively Low Risk for Promotion of Clostridioides difficile Infection? [0.03%]
多西环素为何促进艰难梭菌感染的风险相对较低？
Dongyan Xu,Thriveen S C Mana,Jennifer L Cadnum et al.
Dongyan Xu et al.
Background: Clinical studies suggest that doxycycline poses a low risk for promotion of Clostridioides difficile infection, but the microbiologic explanation for this finding is unclear. ...
Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies [0.03%]
口服奈马特雷韦对长期新冠症状的影响：4个病例及系统研究的理由
Michael J Peluso,Khamal Anglin,Matthew S Durstenfeld et al.
Michael J Peluso et al.
Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and treatment on the development and persistence of Long COVID have intensified. ...
Ultraviolet-C Light-emitting Device Against Microorganisms in Beauty Salons [0.03%]
美容院紫外线C发光设备抗微生物研究
Margarete Teresa Gottardo de Almeida,Bianca Gottardo de Almeida,João Paulo Zen Siqueira et al.
Margarete Teresa Gottardo de Almeida et al.
Background: Ultraviolet light in the UV-C band is also known as germicidal radiation, and it is widely used for decontamination and disinfection of environments, water, and food. The ultraviolet source transfers electroma...
Planes, Trains, and Automobiles: Use of Carbon Dioxide Monitoring to Assess Ventilation During Travel [0.03%]
交通工具中的二氧化碳监测以评估通风效果
Jennifer L Cadnum,Heba Alhmidi,Curtis J Donskey
Jennifer L Cadnum
Background: Travel poses a risk for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses. Poorly ventilated indoor settings pose a particularly high risk for transmiss...
SARS in Cars: Carbon Dioxide Levels Provide a Simple Means to Assess Ventilation in Motor Vehicles [0.03%]
汽车中的SARS：二氧化碳水平提供了一种简单的方法来评估机动车内的通风状况
Muhammed F Haq,Jennifer L Cadnum,Matthew Carlisle et al.
Muhammed F Haq et al.
Background: Poorly ventilated enclosed spaces pose a risk for airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses. Limited information is available on ventil...
A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection [0.03%]
斑马鱼胚胎单细胞水平尿路致病性大肠杆菌感染免疫反应的初步研究
Ashley Rawson,Vijay Saxena,Hongyu Gao et al.
Ashley Rawson et al.
Background: Uropathogenic Escherichia coli (UPEC) infections are common and when they disseminate can be of high morbidity. Methods: We...