Katherine A Wilkinson
Katherine A Wilkinson
The muscle spindle is an important sense organ for motor control and proprioception. Specialized intrafusal fibers are innervated by both stretch sensitive afferents and γ motor neurons that control the length of the spindle and tune the s...
Jason A Mears,Rajesh Ramachandran
Jason A Mears
Dynamin-related protein 1 (Drp1), the master regulator of mitochondrial division (MD), interacts with the cytoskeletal elements, namely filamentous actin (F-actin), microtubules (MT), and septins that coincidentally converge at MD sites. Ho...
Somatosensation a la mode: plasticity and polymodality in sensory neurons [0.03%]
时尚的躯体感觉：来自感官神经元的可塑性和多模态性
Edward C Emery,John N Wood
Edward C Emery
Our understanding of how peripheral damage-sensing neurons (nociceptors) respond to noxious stimuli is fundamental to the development of effective analgesics. To date, numerous studies have presented diverging hypotheses on how nociceptors ...
Autophagy in severe acute respiratory syndrome coronavirus 2 infection [0.03%]
自噬在严重急性呼吸系统综合症冠状病毒2感染中的作用
Di Chen,Hong Zhang
Di Chen
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) orchestrates host factors to remodel endomembrane compartments for various steps of the infection cycle. SARS-CoV-2 also intimately intersects with the catabolic autophagy pathway...
René R Sevag Packard
René R Sevag Packard
Cardiotoxicity, or the development of unwarranted cardiovascular side-effects of oncologic therapies, can involve all aspects of cardiovascular disease. The development of cardiac fibrosis is a dreaded complication that leads to cardiac mec...
Shuaishuai Hu,Thomas M Vondriska
Shuaishuai Hu
Fibroblasts are central to the acute and chronic response of tissues to stress: they are necessary for wound healing, involved in inflammatory responses and critical for long term remodeling of tissue. These diverse roles of fibroblasts ari...
Zhaoxia Sun
Zhaoxia Sun
The cilium is a cell surface organelle with unique composition and shape. Although it has now been well appreciated as a signaling compartment for the vertebrate cell, the regulation and function of intraciliary calcium is less clear and so...
Charleen T Chu
Charleen T Chu
The brain is one of the most energetically demanding tissues in the human body, and mitochondrial pathology is strongly implicated in chronic neurodegenerative diseases. In contrast to acute brain injuries in which bioenergetics and cell de...
Neutrophil crosstalk during cardiac wound healing after myocardial infarction [0.03%]
心肌梗死后心脏伤口愈合期间的中性粒细胞相互作用
Upendra Chalise,Mediha Becirovic-Agic,Merry L Lindsey
Upendra Chalise
Myocardial infarction (MI) initiates an intense inflammatory response that induces neutrophil infiltration into the infarct region. Neutrophils commence the pro-inflammatory response that includes upregulation of cytokines and chemokines (e...
Walter E Knight,Kathleen C Woulfe
Walter E Knight
Since cardiac relaxation is commonly impaired in heart failure caused by many different etiologies, identifying druggable targets is a common goal. While many factors contribute to cardiac relaxation, this review focuses on sarcomeric relax...