Autophagy in severe acute respiratory syndrome coronavirus 2 infection [0.03%]
自噬在严重急性呼吸系统综合症冠状病毒2感染中的作用
Di Chen,Hong Zhang
Di Chen
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) orchestrates host factors to remodel endomembrane compartments for various steps of the infection cycle. SARS-CoV-2 also intimately intersects with the catabolic autophagy pathway...
René R Sevag Packard
René R Sevag Packard
Cardiotoxicity, or the development of unwarranted cardiovascular side-effects of oncologic therapies, can involve all aspects of cardiovascular disease. The development of cardiac fibrosis is a dreaded complication that leads to cardiac mec...
Shuaishuai Hu,Thomas M Vondriska
Shuaishuai Hu
Fibroblasts are central to the acute and chronic response of tissues to stress: they are necessary for wound healing, involved in inflammatory responses and critical for long term remodeling of tissue. These diverse roles of fibroblasts ari...
Zhaoxia Sun
Zhaoxia Sun
The cilium is a cell surface organelle with unique composition and shape. Although it has now been well appreciated as a signaling compartment for the vertebrate cell, the regulation and function of intraciliary calcium is less clear and so...
Charleen T Chu
Charleen T Chu
The brain is one of the most energetically demanding tissues in the human body, and mitochondrial pathology is strongly implicated in chronic neurodegenerative diseases. In contrast to acute brain injuries in which bioenergetics and cell de...
Neutrophil crosstalk during cardiac wound healing after myocardial infarction [0.03%]
心肌梗死后心脏伤口愈合期间的中性粒细胞相互作用
Upendra Chalise,Mediha Becirovic-Agic,Merry L Lindsey
Upendra Chalise
Myocardial infarction (MI) initiates an intense inflammatory response that induces neutrophil infiltration into the infarct region. Neutrophils commence the pro-inflammatory response that includes upregulation of cytokines and chemokines (e...
Walter E Knight,Kathleen C Woulfe
Walter E Knight
Since cardiac relaxation is commonly impaired in heart failure caused by many different etiologies, identifying druggable targets is a common goal. While many factors contribute to cardiac relaxation, this review focuses on sarcomeric relax...
Jian-You Lin,Bradly T Stone,Linnea E Herzog et al.
Jian-You Lin et al.
Modern techniques that enable identification and targeted manipulation of neuron groups are frequently used to bolster theories that attribute specific behavioral functions to specific neuron types. These same techniques can also be used, h...
Mitochondria and ferroptosis [0.03%]
线粒体与铁死亡
Sabzali Javadov
Sabzali Javadov
Ferroptosis is a regulated iron-dependent cell death mechanism accompanied by the accumulation of peroxidized phospholipids, particularly phosphatidylethanolamine, in the cell. It occurs due to the disbalance between production and eliminat...
Cyclophilin D regulation of the mitochondrial permeability transition pore [0.03%]
环磷肽素D对线粒体渗透性转换孔道的调节作用
Elizabeth Murphy
Elizabeth Murphy
The opening of the mitochondrial permeability transition pore (PTP) has been proposed to play a critical role in activating cell death in many settings, including cardiac ischemia and reperfusion. Although the identity of pore forming unit ...