Jordan H Mallette,Breland F Crudup,Barbara T Alexander
Jordan H Mallette
Preeclampsia remains a major health concern for mother and child. Yet, treatment options remain limited to early delivery. Placental dysfunction in preeclampsia occurs in response to an increase in oxidative stress and inflammatory cytokine...
Jinsei Jung,Ulrich Müller
Jinsei Jung
Hair cells of the mammalian cochlea are specialized mechanosensory cells that convert mechanical stimuli into electrical signals to initiate the neuronal responses that lead to the perception of sound. The mechanoelectrical transduction (ME...
Kimberly N Burgos Villar,Xiaoyi Liu,Eric M Small
Kimberly N Burgos Villar
Cardiac fibroblasts play critical roles in the maintenance of cardiac structure and the response to cardiac insult. Extracellular matrix deposition by activated resident cardiac fibroblasts, called myofibroblasts, is an essential wound heal...
Melissa J Hoyer,Sharan Swarup,J Wade Harper
Melissa J Hoyer
Lysosomes are subjected to physiological and patho-physiological insults over the course of their life cycle and are accordingly repaired or recycled. Lysophagy, the selective degradation of lysosomes via autophagy, occurs upon unrepairable...
Dominic P Del Re
Dominic P Del Re
Cardiac injury initiates a tissue remodeling process in which aberrant fibrosis plays a significant part, contributing to impaired contractility of the myocardium and the progression to heart failure. Fibrotic remodeling is characterized by...
Jade A Blackwell,Kristin I Stanford
Jade A Blackwell
Exercise leads to numerous beneficial whole-body effects and can protect against the development of obesity, cardiometabolic, and neurodegenerative diseases. Recent studies have highlighted the importance of inter-organ crosstalk with a foc...
Somatosensory deafferentation reveals lateralized roles of proprioception in feedback and adaptive feedforward control of movement and posture [0.03%]
躯体感觉去传入神经揭示了姿势和运动的反馈和自适应前馈控制中的本体感受作用侧化现象
Shanie A L Jayasinghe,Fabrice R Sarlegna,Robert A Scheidt et al.
Shanie A L Jayasinghe et al.
Proprioception provides crucial information necessary for determining limb position and movement, and plausibly also for updating internal models that might underlie the control of movement and posture. Seminal studies of upper-limb movemen...
Katherine A Wilkinson
Katherine A Wilkinson
The muscle spindle is an important sense organ for motor control and proprioception. Specialized intrafusal fibers are innervated by both stretch sensitive afferents and γ motor neurons that control the length of the spindle and tune the s...
Jason A Mears,Rajesh Ramachandran
Jason A Mears
Dynamin-related protein 1 (Drp1), the master regulator of mitochondrial division (MD), interacts with the cytoskeletal elements, namely filamentous actin (F-actin), microtubules (MT), and septins that coincidentally converge at MD sites. Ho...
Somatosensation a la mode: plasticity and polymodality in sensory neurons [0.03%]
时尚的躯体感觉：来自感官神经元的可塑性和多模态性
Edward C Emery,John N Wood
Edward C Emery
Our understanding of how peripheral damage-sensing neurons (nociceptors) respond to noxious stimuli is fundamental to the development of effective analgesics. To date, numerous studies have presented diverging hypotheses on how nociceptors ...