Danielle J Beetler,DeLisa Fairweather
Danielle J Beetler
Myocarditis is frequently caused by viral infections, but animal models that closely resemble human disease suggest that virus-triggered autoimmune disease is the most likely cause of myocarditis. Myocarditis is a rare condition that occurs...
Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling [0.03%]
内皮屏障重塑过程中Rho GTP酶信号的时空调节机制
Jeffrey Ma van der Krogt,Ivanka Je van der Meulen,Jaap D van Buul
Jeffrey Ma van der Krogt
The vasculature is characterized by a thin cell layer that comprises the inner wall of all blood vessels, the continuous endothelium. Endothelial cells can also be found in the eye's cornea. And even though cornea and vascular endothelial (...
Nathan Campbell,Dylan Solise,Evangeline Deer et al.
Nathan Campbell et al.
A poor uterine environment causes changes in fetal development that affect the health of offspring long-term. Although there are multiple pathways that contribute to the development of cardiovascular and neurological disease, low birth weig...
Michael Simons
Michael Simons
Endothelial-to-mesenchymal transition (EndMT) is a physiological process that is equally important during development and under certain pathological conditions in adult tissues. The last decade has witnessed a remarkable explosion of inform...
m6A RNA methylation: A dynamic regulator of cardiac muscle and extracellular matrix [0.03%]
心肌和细胞外基质的动态调控因子m６A RNA甲基化
Charles P Rabolli,Federica Accornero
Charles P Rabolli
Post-transcriptional modifications encompass a large group of RNA alterations that control gene expression. Methylation of the N6-Adenosine (m6A) of mRNA is a prevalent modification which alters the life cycle of transcripts. The roles that...
IRE1/XBP1 and endoplasmic reticulum signaling - from basic to translational research for cardiovascular disease [0.03%]
IRE1/XBP1及内质网应激信号通路——从基础研究到心血管疾病转化医学的新进展
Fangyi Fu,Shirin Doroudgar
Fangyi Fu
Most cellular protein synthesis, including synthesis of membrane-targeted and secreted proteins, which are critical for cellular and organ crosstalk, takes place at the endoplasmic reticulum (ER), placing the ER at the nexus of cellular sig...
The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis [0.03%]
血管内皮细胞在严重急性呼吸系统综合症冠状病毒2型感染及发病机制中的作用
Rainha Passi,Mairi Brittan,Andrew H Baker
Rainha Passi
Endothelial cell (EC) dysfunction is a characteristic complication of coronavirus-19 (COVID-19). This review discusses the role of the endothelium during the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with...
Xi Wang,Corbin A Shields,Ubong Ekperikpe et al.
Xi Wang et al.
Preeclampsia (PE) is a multisystem obstetric disorder that affects 2-10% of pregnancies worldwide and it is a leading cause of maternal and fetal morbidity and mortality. The etiology of PE development is not clearly delineated, but since d...
Cardiovascular disease and feminizing gender-affirming hormone therapy: Implications for the provision of safe and lifesaving care [0.03%]
心血管疾病与女性化性别确认荷尔蒙治疗的关联：对安全有效护理提供的启示
Abby M Pribish,Sean J Iwamoto
Abby M Pribish
Sex recorded at birth, gender identity, and feminizing gender-affirming hormone therapy (fGAHT) likely contribute to cardiovascular disease (CVD) risk in transgender women. Understanding the interplay of these factors is necessary for the p...
Autophagy at the synapse, an early site of dysfunction in neurodegeneration [0.03%]
自噬在突触中的作用：神经退行性疾病早期功能障碍的起源
Hilary Grosso Jasutkar,Ai Yamamoto
Hilary Grosso Jasutkar
Macroautophagy, herein referred to as autophagy, has long been implicated in the pathophysiology of neurodegenerative diseases. However, an incomplete understanding of how autophagy contributes to disease pathogenesis has limited progress i...