Mitochondrial lysine acylation and cardiometabolic stress: Truth or consequence? [0.03%]
线粒体赖氨酸酰化和心-代谢压力：真相还是后果？
Deborah M Muoio,Ashley S Williams,Paul A Grimsrud
Deborah M Muoio
Disruptions in oxidative metabolism are often accompanied by tissue accumulation of catabolic carbon intermediates, including acyl CoA molecules that can react with the epsilon amino group of lysine residues on cellular proteins. In general...
Biogenesis and secretion of mitovesicles, small extracellular vesicles of mitochondrial origin at the crossroads between brain health and disease [0.03%]
位于大脑健康与疾病交叉路口的线粒体微泡的生物发生和分泌及其作为小型细胞外囊泡的作用
Yohan Kim,Pasquale D&#x;Acunzo,Efrat Levy
Yohan Kim
In the brain, mitochondrial components are released into the extracellular space via several mechanisms, including a recently identified type of extracellular vesicles called mitovesicles. While vesiculation of neuronal mitochondria yields ...
Unheralded Adrenergic Receptor Signaling in Cellular Oxidative Stress and Death [0.03%]
未被重视的肾上腺素受体在细胞氧化应激和死亡中的作用
Lilly Underwood,Chun-Sun Jiang,Joo-Yeun Oh et al.
Lilly Underwood et al.
Catecholamines (CAs) bind and activate adrenergic receptors (ARs), thus exuding a key role in cardiac adaptations to global physiological queues. Prolonged exposure to high levels of CAs promotes deleterious effects on the cardiovascular sy...
Chinwendu Amazu,Juan J Ferreira,Celia M Santi et al.
Chinwendu Amazu et al.
In excitable cells such as neurons and cardiomyocytes, sodium influx across the plasma membrane contributes to the resting membrane potential, and sodium is the key ion for generating action potentials. In myometrial smooth muscle cells, ho...
Acute and chronic effects of vaping electronic devices on lung physiology and inflammation [0.03%]
电子烟设备对肺生理和炎症的急性及慢性影响
Jorge A Masso-Silva,Min Kwang Byun,Laura E Crotty Alexander
Jorge A Masso-Silva
The impact of e-cigarette use on the inflammatory state and function of the lungs is not well understood. Here we review the latest studies on the impact of short and long term e-cigarette aerosol inhalation on molecular pathways, cellular ...
Regulation, Maintenance, and Remodeling of High Endothelial Venules in Homeostasis, Inflammation, and Cancer [0.03%]
静止状态、炎症和癌症中的高内皮微静脉的调节、维持与重建
Nancy H Ruddle
Nancy H Ruddle
High endothelial venules (HEVs), high walled cuboidal blood vessels, through their expression of adhesion molecules and chemokines, allow the entrance of lymphoid cells into primary, secondary, and tertiary lymphoid structures (aka tertiary...
Transcriptional regulators of arterial and venous identity in the developing mammalian embryo [0.03%]
发育中的哺乳动物胚胎中动脉和静脉身份的转录调控因子
Ian R McCracken,Andrew H Baker,Nicola Smart et al.
Ian R McCracken et al.
The complex and hierarchical vascular network of arteries, veins, and capillaries features considerable endothelial heterogeneity, yet the regulatory pathways directing arteriovenous specification, differentiation, and identity are still no...
β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure [0.03%]
β-arrestin介导的β肾上腺素能受体信号转导及其在心力衰竭中的潜在作用
Preston C Nibley,Sudha K Shenoy
Preston C Nibley
The lethality of heart failure (HF), particularly in the context of post-acute sequelae SARS-CoV-2 infection (PASC)-related myocarditis, necessitates the discovery of the cellular pathways implicated in cardiovascular disease (CVD). We summ...
Melissa A Luse,Madeline G Jackson,Zuzanna J Juśkiewicz et al.
Melissa A Luse et al.
Endothelial caveolae are essential for a wide range of physiological processes and have emerged as key players in vascular biology. Our understanding of caveolar biology in endothelial cells has expanded dramatically since their discovery r...
Alexandra M Huffman,Samar Rezq,Jelina Basnet et al.
Alexandra M Huffman et al.
Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. PCOS is diagnosed by the presence of two of the following three characteristics: hyperandrogenemia and/or hyperandrogenism, oligo/amenorrhea, ...