Cell biological mechanisms in regulation of the post-infarction inflammatory response [0.03%]
心梗后炎症反应的细胞生物学机制
Nikolaos G Frangogiannis
Nikolaos G Frangogiannis
Inflammation plays a crucial role in cardiac repair, but may also extend ischemic injury and contribute to post-infarction remodeling. This review manuscript discusses recent advances in our understanding of the cell biology of the post-inf...
Physiology of Cardiac Development: From Genetics to Signaling to Therapeutic Strategies [0.03%]
心脏发育生理学：从基因学到信号转导到治疗策略
Cheng Sun,Maria I Kontaridis
Cheng Sun
The heart is one of the first organs to form and function during embryonic development. It is comprised of multiple cell lineages, each integral for proper cardiac development, and include cardiomyocytes, endothelial cells, epicardial cells...
Michelle D Tallquist
Michelle D Tallquist
The cardiac fibroblast has essential roles in production and maintenance of extracellular matrix. While its role in maladaptive myocardial remodeling has been a focus of many studies, the cardiac fibroblast has become a topic of great inter...
Yuan Dai,Weijia Luo,Jiang Chang
Yuan Dai
Rho kinases (ROCKs) are the first discovered RhoA effectors that are now widely known for their effects on actin organization. Recent studies have shown that ROCKs play important roles in cardiac physiology. Abnormal activation of ROCKs par...
Amanda J LeBlanc,Natia Q Kelm,Monika George
Amanda J LeBlanc
Advancing age will affect every individual and its impact on cardiac health deserves significant attention. The age-related physiological changes occurring in the coronary vasculature, myocardium, and valves set the stage upon which cardiov...
Mark A Lampert,Åsa B Gustafsson
Mark A Lampert
Autophagy is a well-known intracellular degradation process involved in clearing damaged or unnecessary components in cells. Functional autophagy is important for cardiac homeostasis. Given this, it is not surprising that dysregulation of a...
The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology [0.03%]
Smyd家族甲基转移酶在心脏和骨骼肌生理及病理中的作用
Christopher Tracy,Junco S Warren,Marta Szulik et al.
Christopher Tracy et al.
Protein methylation plays a pivotal role in the regulation of various cellular processes including chromatin remodeling and gene expression. SET and MYND domain-containing proteins (Smyd) are a special class of lysine methyltransferases who...