William A Catterall
William A Catterall
Dravet Syndrome is a devastating childhood epilepsy disorder with high incidence of premature death plus comorbidities of ataxia, circadian rhythm disorder, impaired sleep quality, autistic-like social-interaction deficits and severe cognit...
Gary J Iacobucci,Gabriela K Popescu
Gary J Iacobucci
NMDA receptors are a diverse family of excitatory channels with critical roles in central synaptic transmission, development, and plasticity. Controlled expression of seven subunits and their combinatorial assembly into tetrameric receptors...
Regulation of microdomain voltage-gated L-type calcium channels in cardiac health and disease [0.03%]
心肌局部电压门控L型钙通道在心脏健康与疾病中的作用
Zunaira Shuja,Henry M Colecraft
Zunaira Shuja
Cav1.2 channels in the heart mediate excitation-contraction (E-C) coupling; tune cardiac excitability; and regulate gene expression. In ventricular myocytes, CaV1.2 channels are predominantly located in t-tubules where they are in proximity...
Resident cells of the myocardium: more than spectators in cardiac injury, repair and regeneration [0.03%]
心肌室 resident 细胞：心脏损伤、修复和再生的重要参与者
G A Gray,I S Toor,Rfp Castellan et al.
G A Gray et al.
Multiple resident cell types contribute to maintaining the structure and physiological function of the heart over the life course. Cardiomyocyte proliferation supports scar free regeneration in the neonatal heart following injury, but a low...
Wenshu XiangWei,Yuwu Jiang,Hongjie Yuan
Wenshu XiangWei
A significant number of variants/mutations in the N-methyl-D-aspartate glutamatergic receptor (NMDAR) gene family (GRIN) have been identified along with stunning advances in the technologies of next generation of whole-exome sequencing. Mut...
More than a powerplant: the influence of mitochondrial transfer on the epigenome [0.03%]
超越能量工厂——线粒体转移对表观基因组的影响
Alexander N Patananan,Alexander J Sercel,Michael A Teitell
Alexander N Patananan
Each cell in the human body, with the exception of red blood cells, contains multiple copies of mitochondria that house their own genetic material, the maternally inherited mitochondrial DNA. Mitochondria are the cell's powerplant due to th...
CatSper: A Unique Calcium Channel of the Sperm Flagellum [0.03%]
猫精子顶体外钙离子通道CATSPER的功能研究及其表达载体的构建与鉴定
Polina V Lishko,Nadja Mannowetz
Polina V Lishko
To overcome egg protective vestments and ensure successful fertilization, mammalian spermatozoa switch symmetrical progressive motility to a powerful, whip-like flagellar motion, known as hyperactivation. The latter is triggered by a calciu...
Triheteromeric NMDA receptors: from structure to synaptic physiology [0.03%]
结构决定功能的三聚体NMDA受体：从结构到生理功能
David Stroebel,Mariano Casado,Pierre Paoletti
David Stroebel
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that play crucial roles in brain development and synaptic plasticity. They are also therapeutic targets of interest since their dysfunction is associated with multiple...
Ion permeation in ionotropic glutamate receptors: Still dynamic after all these years [0.03%]
激动性谷氨酸受体离子传导若干问题：多年来的若干思考与进展
Lonnie P Wollmuth
Lonnie P Wollmuth
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the vast majority of fast synaptic transmission in the nervous system. When the iGluR ion channel is in the open or conducting conformation, it is non-select...
Cardiac pathophysiology in response to environmental stress: a current review [0.03%]
环境应激下心脏病理生理学的当前研究进展及应对策略——一次综述
Vineeta Tanwar,Aashish Katapadi,Jeremy M Adelstein et al.
Vineeta Tanwar et al.
Purpose: Environmental stressors are disturbing our ecosystem at an accelerating rate. An increasingly relevant stressor are air pollutants, whose levels are increasing worldwide with threats to human health. These air po...