NAD(H) in mitochondrial energy transduction: implications for health and disease [0.03%]
线粒体能量传递中的NAD(H): 对健康和疾病的启示
Matthew A Walker,Rong Tian
Matthew A Walker
Mitochondria are intracellular organelles that oxidize nutrients, make ATP, and fuel eukaryotic life. Their energy providing function is directly dependent on enzymes and coenzymes contained within the organelle. Perhaps, the most important...
San-Pin Wu,Olivia M Emery,Francesco J DeMayo
San-Pin Wu
Pregnancy is a complex process that involves crosstalk among multiple cell types in both the endometrial and myometrial compartments at the maternal side to support the fetus. Genetic engineered mouse models have served as a major platform ...
Barry Fine,Gordana Vunjak-Novakovic
Barry Fine
In this short review, we draw parallels and stress differences between heart regeneration in mice and human, from a bioengineering perspective. As the prevailing dogma that the adult heart is completely post-mitotic is starting to change, t...
Julie A Williams,Nirinjini Naidoo
Julie A Williams
Sleep is a universal phenomenon occurring in all species studied thus far. Sleep loss results in adverse physiological effects at both the organismal and cellular levels suggesting an adaptive role for sleep in the maintenance of overall he...
Joseph Lesnak,Kathleen A Sluka
Joseph Lesnak
Conditions with chronic widespread non-inflammatory muscle pain, such as fibromyalgia, have complex etiologies with numerous proposed mechanisms for their pathophysiology of underlying chronic pain. Advancements in neuroimaging have allowed...
Nora Yucel,Zolt Arany
Nora Yucel
Endothelial cells line all blood vessels in vertebrates. These cells contribute to whole-body nutrient distribution in a variety of ways, including regulation of local blood flow, regulation of trans-endothelial nutrient transport, and para...
Nociceptor subtypes and their incidence in rat lumbar dorsal root ganglia (DRGs): focussing on C-polymodal nociceptors, Aβ-nociceptors, moderate pressure receptors and their receptive field depths [0.03%]
大鼠腰神经节痛觉感受器亚型及其在腰神经节中的分布：以C类多模式伤害感受器、Aβ伤害感受器和中压感受器为研究重点及其敏感部位深度分布规律
Sally N Lawson,Xin Fang,Laiche Djouhri
Sally N Lawson
A recent study with Ca++-sensitive-dyes in neurons in whole DRGs (Table 5) found that much lower percentages of nociceptors were polymodal-nociceptors (PMNs) (Emery et al., 2016), than the 50-80% values in many electrophysiological fiber st...
Christopher A Wolff,Karyn A Esser
Christopher A Wolff
Circadian rhythms and exercise physiology are intimately linked, but the symbiosis of this relationship has yet to be fully unraveled. Exercise exerts numerous health benefits from the organelle to the organism. Proper circadian function is...
Greg Dussor
Greg Dussor
Migraine is among the most common and most disabling disorders worldwide, yet its underlying pathophysiology is among the most poorly understood. New information continues to emerge on mechanisms within the central and peripheral nervous sy...
Sherif M Badawy,Emily F Law,Tonya M Palermo
Sherif M Badawy
Over half of youth with chronic pain report sleep deficiency including difficulties falling asleep, maintaining sleep, feeling unrested, and experiencing short sleep duration. Sleep deficiency has been shown to play a causal role in the dev...