James H Baraniak Jr,Yandong Zhou,Robert M Nwokonko et al.
James H Baraniak Jr et al.
Store-operated Ca2+ entry signals are critical for cellular regulation. This intricate signaling pathway involves coupling of proteins in two different membranes: the ER-resident Ca2+-sensing STIM proteins and the highly Ca2+-selective PM O...
PHOSPHOINOSITIDES AND CALCIUM SIGNALING. A MARRIAGE ARRANGED IN ER-PM CONTACT SITES [0.03%]
磷脂酰肌醇和钙信号。在内质网-质膜接触位点的安排组合
Tamas Balla,Gergo Gulyas,Yeun Ju Kim et al.
Tamas Balla et al.
Calcium (Ca2+) ions are critically important in orchestrating countless regulatory processes in eukaryotic cells. Consequently, cells tightly control cytoplasmic Ca2+ concentrations using a complex array of Ca2+-selective ion channels, tran...
New insights into cortical development and plasticity: from molecules to behavior [0.03%]
皮层发育和可塑性的新见解：从分子到行为
Woon Ju Park,Ione Fine
Woon Ju Park
The human brain contains 100 billion neurons, and each neuron can have up to 200,000 connections to other neurons. Recent advancements in neuroscience-ranging from molecular studies in animal models to behavioral studies in humans-have give...
Lina Aj Reiss
Lina Aj Reiss
Cochlear implants (CIs) are implantable auditory prostheses designed to restore access to sound in deaf individuals via direct electrical stimulation of the auditory nerve. While CIs have been successful in restoring speech perception to ma...
Wolfram Syndrome: a Monogenic Model to Study Diabetes Mellitus and Neurodegeneration [0.03%]
沃尔弗拉姆综合症：用以研究糖尿病和神经退行性的单基因模型
Tom T Fischer,Barbara E Ehrlich
Tom T Fischer
Wolfram syndrome (WS) is a rare, progressive disorder characterized by childhood-onset diabetes mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and neurodegeneration. Currently, there is no effective treatment for WS, and p...
Aaron J Levi,Alexander C Huk
Aaron J Levi
Perceptual decisions are informed by the accumulation of sensory evidence over time, but the form of this fundamental temporal computation is not fully understood. Characterizations of the temporal integration of sensory stimuli in behavior...
Mark S Blumberg,James C Dooley,Greta Sokoloff
Mark S Blumberg
Given the prevalence of sleep in early development, any satisfactory account of infant brain activity must consider what happens during sleep. Only recently, however, has it become possible to record sleep-related brain activity in newborn ...
Michelle A Guney,David S Lorberbaum,Lori Sussel
Michelle A Guney
Diabetes is a major worldwide health problem which results from the loss and/or dysfunction of pancreatic insulin-producing β cells in the pancreas. Therefore, there is great interest in understanding the endogenous capacity of β cells to...
Drug discovery strategies for the identification of novel regulators of uterine contractility [0.03%]
用于识别新的子宫收缩调节因子的药物发现策略
Shajila Siricilla,Chisom C Iwueke,Jennifer L Herington
Shajila Siricilla
Preterm birth and postpartum hemorrhage are the leading causes of neonatal and maternal morbidities worldwide, respectively. Current clinically utilized tocolytics and uterotonics to manage these obstetric conditions are limited due to thei...
Racheli Wercberger,Allan I Basbaum
Racheli Wercberger
Today there are extensive maps of the molecular heterogeneity of primary afferents and dorsal horn interneurons, yet there is a dearth of molecular and functional information regarding the projection neurons that transmit pain and itch info...