Cochlear mechanics: new insights from vibrometry and Optical Coherence Tomography [0.03%]
听小骨力学：振动测量和光学 coherence 检测技术的新观点
Elizabeth S Olson,C Elliott Strimbu
Elizabeth S Olson
The cochlea is a complex biological machine that transduces sound-induced mechanical vibrations to neural signals. Hair cells within the sensory tissue of the cochlea transduce vibrations into electrical signals, and exert electromechanical...
María Eulalia Rubio
María Eulalia Rubio
During development and adulthood, the normal activity of the auditory nerve plays a critical role in the maintenance of both fundamental structural, molecular, and functional parameters of auditory nerve synapses, and the postsynaptic excit...
Yinhu Wang,Anthony Tao,Martin Vaeth et al.
Yinhu Wang et al.
T cells are an essential component of the immune system that provide antigen-specific acute and long lasting immune responses to infections and tumors, ascertain the maintenance of immunological tolerance and, on the flipside, mediate autoi...
Edmund J Carvalho,Peter B Stathopulos,Muniswamy Madesh
Edmund J Carvalho
Mitochondrial calcium (mCa2+) homeostasis also plays a key role in the buffering of cytosolic calcium (cCa2+) and calcium transported into the mitochondrial matrix regulates cellular metabolism, migration and cell fate decisions. Recent wor...
Time to get ill: the intersection of viral infections, sex, and the X chromosome [0.03%]
得病的时机：病毒性感染、性别和X染色体的交集
Katherine S Forsyth,Montserrat C Anguera
Katherine S Forsyth
Females have more robust immune responses than males, and viral infections are more severe for males. Hormones and genetic sex, namely the X chromosome, influence sex differences with immune responses. Here, we review recent findings underl...
David M Patrick,Justin P Van Beusecum,Annet Kirabo
David M Patrick
Hypertension remains the most important modifiable risk factor for the development of cardiovascular disease. While it is clear that inflammation plays a pivotal role in the development and maintenance of hypertension, several novel discove...
Ryan E Yoast,Scott M Emrich,Mohamed Trebak
Ryan E Yoast
The ubiquitous store-operated Ca2+ entry pathway mediated by plasma membrane Ca2+ release-activated Ca2+ (CRAC) channels regulates a wide variety of physiological functions. While it is clearly established that the ORAI1 protein is essentia...
Noise-Induced Hearing Loss and its Prevention: Current Issues in Mammalian Hearing [0.03%]
噪声引起的听力损失及其预防：哺乳动物听力的当前问题
Colleen G Le Prell,Troy A Hackett,Ramnarayan Ramachandran
Colleen G Le Prell
Noise-induced hearing loss (NIHL) has been well investigated across diverse mammalian species and the potential for prevention of NIHL is of broad interest. To most efficiently develop novel therapeutic interventions, a good understanding o...
Ranran L French,Gregory C DeAngelis
Ranran L French
Neurophysiological studies of multisensory processing have largely focused on how the brain integrates information from different sensory modalities to form a coherent percept. However, in the natural environment, an important extra step is...
Pablo Argüeso
Pablo Argüeso
The cornea is a transparent avascular tissue on the anterior segment of the eye responsible for providing refractive power and forming a protective barrier against the external environment. Infectious and inflammatory conditions can comprom...