Recent Advances in GPCR-Regulated Leukocyte Responses during Acute Cardiac Injury [0.03%]
急性心脏损伤时GPCR调节的白细胞反应的最新进展
Tapas K Nayak,Douglas G Tilley
Tapas K Nayak
Following acute cardiac injury such as myocardial infarction (MI), the controlled activation and recruitment of various leukocytes to the site of tissue damage significantly impacts chronic changes to cardiac structure and function, and ult...
Continuous speech processing [0.03%]
连续语音处理
Christian Brodbeck,Jonathan Z Simon
Christian Brodbeck
Speech processing in the human brain is grounded in non-specific auditory processing in the general mammalian brain, but relies on human-specific adaptations for processing speech and language. For this reason, many recent neurophysiologica...
Mechanism of STIM activation [0.03%]
STIM激活机制
Marc Fahrner,Herwig Grabmayr,Christoph Romanin
Marc Fahrner
Store-operated calcium entry (SOCE) through Orai ion channels is an intracellular signaling pathway that is initiated by ligand-induced depletion of calcium from the endoplasmic reticulum (ER) store. The molecular link between SOCE and ER s...
Bernadett Bacsa,Oleksandra Tiapko,Thomas Stockner et al.
Bernadett Bacsa et al.
The transient receptor potential (TRP) superfamily of plasma membrane cation channels has been recognized as a signaling hub in highly diverse settings of human physiopathology. In the past three decades of TRP research, attention was focus...
Ruoshui Li,Nikolaos G Frangogiannis
Ruoshui Li
Several members of the chemokine family are involved in regulation of fibrosis. This review manuscript discusses the role of the chemokines in the pathogenesis of myocardial fibrosis. The CC chemokine CCL2 exerts fibrogenic actions through ...
Britany A Law,William D Hancock,L Ashley Cowart
Britany A Law
Obesity, Type 2 Diabetes, and Metabolic Syndrome induce dyslipidemia resulting in inundation of peripheral organs with fatty acids. These not only serve as substrates for energy production, but also contribute to aberrant production of bioa...
Optogenetic approaches to control Ca2+-modulated physiological processes [0.03%]
用于调控钙离子门控生理过程的光遗传方法
Nhung T Nguyen,Guolin Ma,Yubin Zhou et al.
Nhung T Nguyen et al.
As a versatile intracellular second messenger, calcium ion (Ca2+) regulates a plethora of physiological processes. To achieve precise control over Ca2+ signals in living cells and organisms, a set of optogenetic tools have recently been cra...
Revisiting the role of hypoxia-inducible factors in pulmonary hypertension [0.03%]
低氧诱导因子在肺动脉高压中作用的再评价
Larissa A Shimoda,Xin Yun,Gautam Sikka
Larissa A Shimoda
Pulmonary hypertension (PH) is a deadly condition with limited treatment options. Early studies implicated hypoxia-inducible factors as contributing to the development of hypoxia-induced PH. Recently, the use of cells derived from patients ...
Immune cell Dilemma in Ischemic Cardiomyopathy: To Heal or Not to Heal [0.03%]
缺血性心肌病中的免疫细胞治疗两难：愈合还是不愈合？
Sarita Nehra,Richard J Gumina,Shyam S Bansal
Sarita Nehra
Inflammation is a double-edged sword for sterile tissue injury such as in myocardial infarction (MI). After ischemic injury, inflammatory immune responses activate repair processes, clear tissue-debris, form a stable scar and initiate angio...
Laura Moreno de Lara,Ragav S Parthasarathy,Marta Rodriguez-Garcia
Laura Moreno de Lara
Women acquire HIV through sexual transmission. Women worldwide represent half of the people living with HIV, but young women in endemic areas are disproportionally affected. Low transmission rates per sexual act in women suggest that local ...