Max Thomas,Oliver J Price,James H Hull
Max Thomas
In people recovering from COVID-19, there is concern regarding potential long-term pulmonary sequelae and associated impairment of functional capacity. Data published thus far indicate that spirometric indices appear to be generally well pr...
Oral Signals of Short and Long Chain Fatty Acids: Parallel Taste Pathways to Identify Microbes and Triglycerides [0.03%]
短链和长链脂肪酸的口腔信号：识别微生物和甘油三酯的平行味觉通路
Emily C Hanselman,Nicholas J Amado,Paul A S Breslin
Emily C Hanselman
Both short chain fatty acids (SCFAs) and long chain fatty acids (LCFAs) rely on free fatty acid receptors to signal their presence to the body, but their individual detection and putative reward systems are different. These separate, yet pa...
Bitter Taste Receptors (T2Rs) are Sentinels that Coordinate Metabolic and Immunological Defense Responses [0.03%]
苦味受体(T2R)是协调代谢和免疫防御反应的哨兵
Caroline P Harmon,Daiyong Deng,Paul A S Breslin
Caroline P Harmon
In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irrit...
Converging integration between ascending proprioceptive inputs and the corticospinal tract motor circuit underlying skilled movement control [0.03%]
皮质脊髓运动通路 circuits整合ascending本体感觉输入信息在技能动作控制中的作用
John Kalambogias,Yutaka Yoshida
John Kalambogias
Converging interactions between ascending proprioceptive afferents and descending corticospinal tract projections are critical in the modulation and coordination of skilled motor behaviors. Fundamental to these processes are the functional ...
Emily R Liman,Sue C Kinnamon
Emily R Liman
Sour taste, which is evoked by low pH, is one of the original four fundamental taste qualities, recognized as a distinct taste sensation for centuries, and universally aversive across diverse species. It is generally assumed to have evolved...
Structural Mechanism of Cooperative Regulation of Calcium-Sensing Receptor-Mediated Cellular Signaling [0.03%]
钙敏感受体介导的细胞信号转导的协同调控机制
Xiaonan Deng,Yao Xin,Cassandra Lynn Miller et al.
Xiaonan Deng et al.
Calcaium sensing receptors (CaSRs) play a central role in regulating extracellular calcium (Ca2+) homeostasis and many (patho)physiological processes. This regulation is primarily orchestrated in response to extracellular stimuli via the ex...
Charlotte M Mistretta,Robert M Bradley
Charlotte M Mistretta
When solid or liquid stimuli contact the tongue tip during eating, the sensations of taste, touch and temperature are immediately evoked, and tongue function relies on these simultaneous multimodal responses. We focus on the fungiform papil...
Rethinking the role of taste processing in insular cortex and forebrain circuits [0.03%]
重塑岛叶皮层和脑高级中枢味加工功能的认识
John D Boughter Jr,Max Fletcher
John D Boughter Jr
Over the years, many approaches towards studying the taste-responsive area of insular cortex have focused on how basic taste information is represented, and how lesions or silencing of this area impact taste-focused behaviors. Here, we revi...
Thomas E Finger,Linda A Barlow
Thomas E Finger
Taste buds are the sensory end organs for gustation, mediating sensations of salty, sour, bitter, sweet and umami as well as other possible modalities, e.g. fat and kokumi. Understanding of the structure and function of these sensory organs...
Barry G Green
Barry G Green
To understand human taste requires not only physiological studies ranging from receptor mechanisms to brain circuitry, but also psychophysical studies that quantitatively describe the perceptual output of the system. As obvious as this requ...