Yilin Chen,Juan I Bravo,Jyung Mean Son et al.
Yilin Chen et al.
In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and deregulation of gene expression correlates with aging. A key layer in the study of gene regulation mec...
Translational Geroscience: From invertebrate models to companion animal and human interventions [0.03%]
从无脊椎动物模型到伴侣动物和人类的转化衰老研究
Mitchell B Lee,Matt Kaeberlein
Mitchell B Lee
Translational geroscience is an interdisciplinary field descended from basic gerontology that seeks to identify, validate, and clinically apply interventions to maximize healthy, disease-free lifespan. In this review, we describe a research...
Matt Kaeberlein
Matt Kaeberlein
Advances in geroscience are allowing scientists and clinicians, for the first time, to consider interventions aimed at directly targeting the hallmarks of aging. Unlike disease-specific approaches, such interventions have the potential to p...
Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast [0.03%]
芽殖酵母中的Rb同源物Whi5调节G1到S期的转换和细胞大小但不影响复制衰老期
Matthew M Crane,Mitsuhiro Tsuchiya,Ben W Blue et al.
Matthew M Crane et al.
An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase...
DDS promotes longevity through a microbiome-mediated starvation signal [0.03%]
DDS通过肠道微生物介导的饥饿信号促进长寿
Haeri Choi,Sung Chun Cho,Young Wan Ha et al.
Haeri Choi et al.
The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate k...
An inexpensive microscopy system for microfluidic studies in budding yeast [0.03%]
一种用于研究新生酵母微流体的显微镜系统
Kenneth L Chen,Toby N Ven,Matthew M Crane et al.
Kenneth L Chen et al.
Recently, microfluidic technologies have been developed to allow higher throughput collection of yeast replicative lifespan data. Adoption of these devices has been limited, in part, due to the high cost of the motorized microscopy instrume...