Reji Babygirija,Dudley W Lamming
Reji Babygirija
As a key macronutrient and source of essential macromolecules, dietary protein plays a significant role in health. For many years, protein-rich diets have been recommended as healthy due to the satiety-inducing and muscle-building effects o...
Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae [0.03%]
用于研究酿酒酵母复制衰老的定量生物学方法进展
Richard O&#x;Laughlin,Meng Jin,Yang Li et al.
Richard O&#x;Laughlin et al.
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative disorders, cardiovascular disease and canc...
A toolkit for DNA assembly, genome engineering and multicolor imaging for C. elegans [0.03%]
用于DNA组装、基因组工程和线虫多色成像的工具包
Bryan Sands,Nikolay Burnaevskiy,Soo R Yun et al.
Bryan Sands et al.
One way scientists can observe and quantify processes in living cells is to engineer the genomes of animals to express multiple fluorescent proteins and then quantify those signals by various imaging techniques. To allow our laboratories to...
Emily L Goldberg
Emily L Goldberg
Inflammation is a broad term that refers to a collection of carefully balanced programs in the body. These pathways are essential for detecting invading microorganisms, controlling the spread of infection, and instructing appropriate immune...
Automated phenotyping and lifespan assessment of a C. elegans model of Parkinson's disease [0.03%]
帕金森病线虫模型的表型自动分析及其寿命评估
Minwook Kim,Daniela Knoefler,Ellen Quarles et al.
Minwook Kim et al.
Phenotypic analysis of Caenorhabditis elegans has greatly advanced our understanding of the molecular mechanisms implicated in the aging process as well as in age-related pathologies. However, conventional high-resolution imaging methods an...
SPOCK, an R based package for high-throughput analysis of growth rate, survival, and chronological lifespan in yeast [0.03%]
基于R的酵母生长速率、存活率和生物学寿命的高通量分析包SPOCK
Eric M Small,Daniel P Felker,Olivia C Heath et al.
Eric M Small et al.
Plate reader-based methods for high-throughput measurement of growth rate, cellular survival, and chronological lifespan are a compelling addition to the already powerful toolbox of budding yeast Saccharomyces cerevisiae genetics. These met...
Improving trainee engagement in science: Lessons from a virtual seminar series [0.03%]
改进科学培训生的参与度：虚拟研讨会系列的经验教训
Hannah J Smith
Hannah J Smith
To be a successful researcher, you are expected to have important skills beyond the bench such as being able to ask questions, talk about science with your peers, and organize scientific events. However, there is frequently little to no tra...
Joseph C P Kruempel,Marshall B Howington,Scott F Leiser
Joseph C P Kruempel
The rapid progress of the past three decades has led the geroscience field near a point where human interventions in aging are plausible. Advances across scientific areas, such as high throughput "-omics" approaches, have led to an exponent...
Mitochondrial hyperactivity as a potential therapeutic target in Parkinson's disease [0.03%]
线粒体高度活性可能作为帕金森病的治疗靶点
Danielle E Mor,Coleen T Murphy
Danielle E Mor
Mitochondrial dysfunction is thought to contribute to neurodegeneration in Parkinson's disease (PD), yet the cellular events that lead to mitochondrial disruption remain unclear. Post-mortem studies of PD patient brains and the use of compl...
Daniel P Felker,Christine E Robbins,Mark A McCormick
Daniel P Felker
Aging is a fundamental biological process that is still not fully understood. As many of the most significant human diseases have aging as their greatest risk factor, a better understanding of aging potentially has enormous practical implic...