Next generation technologies for CRISPR-based epigenome and transcriptional modulation [0.03%]
下一代CRISPR表观遗传及转录调控技术
Rithu K Pattali,Nikita S Divekar,James K Nuñez
Rithu K Pattali
Technologies for editing epigenetic modifications and controlling transcription in mammalian cells have revolutionized targeted gene perturbation, functional genomics, and basic research. By avoiding the generation of DNA breaks, epigenome ...
Shiyu Sun,Zhuowei Zhou,Aoife Tang et al.
Shiyu Sun et al.
Symmetry breaking and tissue patterning are fundamental processes in mammalian development. Understanding these events is essential not only for advancing mammalian developmental biology but also for the ongoing efforts to create in vitro m...
Hyaluronic acid-based models of the brain microenvironment: Challenges and advances [0.03%]
基于透明质酸的脑微环境模型：挑战与进展
Anna Weldy,Sanjay Kumar
Anna Weldy
While hyaluronic acid (HA) extracellular matrix (ECM) models continue to provide valuable insights into brain physiology and disease, much room for improvement remains in terms of capturing the cellular and structural complexity of the brai...
Interplay between extracellular matrix mechanics and cell function in mechanobiology [0.03%]
力学生物学中细胞外基质力学与细胞功能的相互作用
Peter A Galie,Paul A Janmey
Peter A Galie
Tissues are composites of cells and extracellular matrix that interact with each other both chemically and mechanically to form functioning organs with defined chemical and physical properties. Changes in the physical properties of the extr...
Rewriting the epigenome: CRISPR tools for biological discovery and therapeutics [0.03%]
重写表观基因组：用于生物学发现和治疗的CRISPR工具
Christian P Otero,Lei S Qi
Christian P Otero
The eukaryotic epigenome plays a central role in regulating gene expression, cellular identity, and development through dynamic, multilayered biochemical modifications to DNA, histones, and chromatin architecture. Disruption of these regula...
Neuromodulation for the treatment of sexual dysfunction: an opportunity for the field [0.03%]
神经调控治疗性功能障碍：一个全新的机遇
Tim M Bruns,Lauren Zimmerman Hershey
Tim M Bruns
Sexual dysfunction affects a substantial number of women and men. Currently there are no commercially available neuromodulation therapies for sexual dysfunction. Neuromodulation has long been used as a third-line therapy for bladder and bow...
Engineering stimuli-responsive extracellular vesicles for enhanced anticancer therapeutics [0.03%]
工程刺激响应型细胞外囊泡以增强抗癌治疗效果
Brian I Molina Diaz,Pei Zhuang,Xiaoshu Pan et al.
Brian I Molina Diaz et al.
Extracellular vesicles (EVs), so called nano-sized vesicles shedding out from cells, have emerged as promising nanocarriers for cancer therapy given their high biocompatibility and low immunogenicity. However, their clinical utility remains...
Aging and the extracellular matrix: A tumor-permissive microenvironment driving cancer progression [0.03%]
衰老与细胞外基质：驱动癌症发展的肿瘤容许型微环境
Lauren Hawthorne,Jun Yang,Pinar Zorlutuna
Lauren Hawthorne
Aging is a significant cancer risk factor, yet its impact on the extracellular matrix (ECM) in tumor initiation and progression has been traditionally overlooked. While significant amounts of research focus on cellular and genetic links bet...
Tianna Edwards,Haylee Wagner,Shelly Peyton
Tianna Edwards
The overwhelming majority of cancer-associated deaths occur due to metastasis-the spread of cells from the primary tumor to distant organs-where disseminated cells eventually colonize and destroy organ function. For metastasis to occur, a c...
Carolina Trenado-Yuste,Celeste M Nelson
Carolina Trenado-Yuste
Tumor progression is a complex, multi-stage process that involves tumor formation, cancer cell invasion, and metastasis and colonization of distant sites. Each stage is driven in part by cell motility and interactions between cancer cells a...