Safe and effective use of nivolumab plus ipilimumab in a patient with metastatic clear-cell renal cell carcinoma with sarcomatoid dedifferentiation and end stage renal disease on hemodialysis [0.03%]
一例IV期透明细胞肾细胞癌合并肉瘤样去分化和终末期肾病血液透析患者的尼伏单抗联合伊匹木单抗治疗的观察记录
Leah K Shaw,Andrew J Wiele,Kanishka Sircar et al.
Leah K Shaw et al.
Targeting the programmed cell death protein-1 (PD-1) and cytotoxic T-lymphocyte associated protein-4 (CTLA-4) pathways using the combination immune checkpoint inhibitors (ICI) nivolumab and ipilimumab is an approved frontline therapy for pa...
High gene expression of estrogen and progesterone receptors is associated with decreased t cell infiltration in patients with NSCLC [0.03%]
高水平雌激素和孕激素受体基因表达与NSCLC患者T细胞浸润降低有关
Michael S Oh,Jonathan F Anker,Young Kwang Chae
Michael S Oh
Objectives: Prior studies have demonstrated that signaling via the estrogen and progesterone receptors (ER and PR) may affect prognosis in non-small cell lung cancer (NSCLC). The precise impact of hormone signaling on cli...
Chemotherapy use in early stage anal canal squamous cell carcinoma and its impact on long-term overall survival,, [0.03%]
早期肛管鳞状细胞癌的化疗应用及其对长期总生存率的影响
Deanna L Huffman,Thejus T Jayakrishnan,Brittany L Vannatter et al.
Deanna L Huffman et al.
Background: The standard of care for non-metastatic squamous cell carcinoma of the anal canal (SCCA) is concurrent chemoradiotherapy. It is postulated that chemotherapy could be omitted for the earliest stages without wor...
Erratic journey of CRISPR/Cas9 in oncology from bench-work to successful-clinical therapy [0.03%]
从实验台到成功的临床治疗：CRISPR/Cas9在肿瘤学中的不规则旅程
Esha Sarkar,Afreen Khan
Esha Sarkar
CRISPR is a customized molecular scissor, comprising genetic guide made of RNA and an enzyme, Cas9 which snips DNA in simpler, cheaper and more precise way than any other gene editing tools. In recent years CRISPR/Cas has taken the research...
Charles Champeaux-Depond,Joconde Weller
Charles Champeaux-Depond
Background: No large-scale study evaluating the usefulness of tamoxifen after meningioma surgery has been undertaken. Methods: We proce...
Malignant mesothelioma without asbestos exposure diagnosed during EGFR-TKI treatment of lung adenocarcinoma: A case report [0.03%]
厄洛替尼治疗肺腺癌期间诊断的无石棉接触史的恶性间皮瘤一例报告
Xiaomin Niu,Chenglei Zhou,Aiyan Hu et al.
Xiaomin Niu et al.
Synchronous malignant mesothelioma (MM) and lung carcinoma are extremely rare in patients without a history of asbestos exposure and poses tremendous difficulties in clinical management. We report a patient without asbestos exposure diagnos...
NVP-BEZ235 or JAKi Treatment leads to decreased survival of examined GBM and BBC cells [0.03%]
NVP-BEZ235或JAKi处理可降低所检测的GBM和BBC细胞存活率
Neftali Vazquez,Alma Lopez,Victoria Cuello et al.
Neftali Vazquez et al.
Cancer cells almost universally harbor constitutively active Phosphatidylinositol-3 Kinase (PI3K) Pathway activity via mutation of key signaling components and/or epigenetic mechanisms. Scores of PI3K Pathway inhibitors are currently under ...
Discordant results in 18F-FDG PET/CT and ultrasound-based assessment for axillary lymph node metastasis detection: A large retrospective analysis in 560 patients with breast cancer [0.03%]
18F-FDG PET/CT与超声检查对乳腺癌腋窝淋巴结转移检测不一致结果的大型回顾性分析（560例）
Sandrine Parisse-Di Martino,Christelle Faure,Thomas Mognetti
Sandrine Parisse-Di Martino
Purpose: Ultrasound is the recommended modality to assess axillary lymph node involvement in breast cancer; nevertheless, 18F-fluorodeoxyglucose (18F-FDG) integrated positron emission tomography/computed tomography (PET/C...
Jan Pawlonka,Beata Rak,Urszula Ambroziak
Jan Pawlonka
Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cyc...
Seied Asadollah Mousavi,Tahereh Rostami,Azadeh Kiumarsi et al.
Seied Asadollah Mousavi et al.
Background: Cancer patients, with an incidence of more than 18 million new cases per year, may constitute a significant portion of the COVID-19 infected population. In the pandemic situation, these patients are considered...