Neoantigen cancer vaccines in the mRNA Era: antigen selection, platform engineering, and clinical translation [0.03%]
mRNA时代的新抗原癌症疫苗：抗原选择、平台工程和临床转化
Minglu Ge,Ning Wu
Minglu Ge
Neoantigen vaccines have become a central direction in precision cancer immunotherapy because they aim to target tumor-specific peptide sequences generated by somatic alterations rather than self-antigens shared with normal tissues. This bi...
Neoantigen cancer vaccines in the mRNA Era: antigen selection, platform engineering, and clinical translation [0.03%]
信使RNA时代的新型抗原癌症疫苗：抗原选择、平台工程和临床转化
Minglu Ge,Ning Wu
Minglu Ge
Neoantigen vaccines have become a central direction in precision cancer immunotherapy because they aim to target tumor-specific peptide sequences generated by somatic alterations rather than self-antigens shared with normal tissues. This bi...
Clinical relative biological effectiveness of carbon-ion versus photon radiotherapy derived from tumor control probability models in locally advanced non-small cell lung cancer [0.03%]
基于肿瘤控制概率模型的碳离子与光子放射治疗的临床相对生物效应在局部晚期非小细胞肺癌中的研究
Yong-Long Liu,Ning-Yi Ma,Ya-Qi Li et al.
Yong-Long Liu et al.
Background: This study aimed to estimate the clinical relative biological effectiveness (cRBE) of carbon-ion radiotherapy (CIRT) versus photon radiotherapy (PRT) in patients with locally advanced non-small cell lung cance...
CRISPR-Cas9 gene editing approaches in colorectal cancer: Current progress and future prospects [0.03%]
基于CRISPR-Cas9基因编辑的结直肠癌研究：现状与展望
Mohadeseh Hassannia,Parisa Amirifar
Mohadeseh Hassannia
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, characterized by genetic heterogeneity and the accumulation of mutations in key oncogenes and tumor suppressor genes. CRISPR-Cas9 technology has greatly advanced...
Artificial intelligence-powered evaluation of the pathologic response to preoperative therapy in non-small cell lung cancer [0.03%]
人工智能驱动的评估非小细胞肺癌术前治疗病理反应的方法
Akira Ono,Takuya Kawata,Mitsuhiro Isaka et al.
Akira Ono et al.
Introduction: Quantitative assessment of the pathologic response (pR) in the eyeball approach remains challenging. Few studies have clearly defined viable tumor cell regions (VTRs). We defined VTRs using AE1/AE3 (AE1/3) s...
Beyond the clinical trial: Real-world treatment patterns and drivers of PD-(L)1 therapy use in first-line metastatic NSCLC [0.03%]
超越临床试验：一线晚期NSCLC患者中PD-(L)1治疗的真实世界应用模式及影响因素分析
Siobhan Halloran,Salman R Punekar,Mark Guinter et al.
Siobhan Halloran et al.
Background: Immunotherapies have improved survival in patients with metastatic non-small cell lung cancer (mNSCLC), yet a substantial fraction of eligible patients remain untreated with immunotherapy in routine clinical p...
CD103+ tissue-resident T-cells in head and neck squamous cell carcinomas of patients treated anti-PD-1 therapy [0.03%]
接受抗PD-1治疗的头颈部鳞状细胞癌患者的CD103⁺组织驻留T细胞
Christine Sanders,Dahlia Kittel,Annkristin Heine et al.
Christine Sanders et al.
Purpose: Anti-PD-1 therapy is nowadays the state of the art treatment in advanced-stage head and neck squamous cell carcinoma (HNSCC), showing improved survival rates in contrast to chemotherapy, but still lacking reliabl...
BRAF V600E Co-mutations predict aggressive clinicopathological features in Chinese patients with differentiated thyroid cancer: A multicenter cohort study [0.03%]
BRAF V600E复合突变提示中国分化型甲状腺癌患者具有更严重的临床病理特征：一项多中心队列研究
Jing Du,Bo Guo,Yunpeng Zhang et al.
Jing Du et al.
Background: The BRAF V600E mutation is a common driver variant in differentiated thyroid carcinoma (DTC); however, the clinical significance of its co-mutation patterns in the Chinese population remains unclear. This stud...
Role of circadian clock in oral squamous cell carcinoma pathogenesis and treatment [0.03%]
生物钟在口腔鳞状细胞癌发生及治疗中的作用研究进展
Mingyuan Liu,Kai Yang
Mingyuan Liu
The circadian clock is an endogenous timing mechanism that enables cellular physiological activities to adapt to environmental changes. It is primarily composed of circadian clock genes and their encoded proteins, which form a transcription...
Human host factors Secretory leukocyte protease inhibitor and Annexin A2 modulate the presence of human papillomavirus DNA, but not Epstein-Barr virus, in nasopharyngeal carcinoma from non-endemic regions [0.03%]
人宿主因素分泌性白细胞蛋白酶抑制剂和钙调神经磷酸酶A2调节人类乳头瘤病毒DNA，但不调节Epstein-Barr病毒在非高发区鼻咽癌中的存在量
Elgar S Quabius,Christiane M Stuhlmann-Laeisz,Henrike B A A Zech et al.
Elgar S Quabius et al.
Background: The human host factors Secretory leukocyte protease inhibitor (SLPI) and Annexin A2 (AnxA2) influence susceptibility of epithelial cells to human papillomavirus (HPV)-infections. Although nasopharyngeal carcin...