The multifaceted role of midkine in gastrointestinal cancer: From biomarker to treatment [0.03%]
胃肠道癌症中midkine的多面作用：从生物标志物到治疗药物
Zahra Rasoulizadeh,Amir Mohammad Nezhad Salari,Arezoo Gowhari Shabgah et al.
Zahra Rasoulizadeh et al.
Gastrointestinal cancer represents a substantial global health challenge, contributing to over one-third of cancer-related mortality worldwide. The progression of these malignancies involves complex molecular and physiological mechanisms, w...
Impact of TGF-β1 on tumor immune microenvironment and prognosis in colorectal liver oligometastasis [0.03%]
TGF-β1对结直肠肝寡转移瘤免疫微环境及预后的影响
Song Wang,Jiahua He,Yuanbin Liao et al.
Song Wang et al.
Background: Colorectal liver oligometastasis (CLO) represents an intermediate state between localized and widely disseminated disease. Transforming growth factor-beta 1 (TGF-β1) plays a stage-dependent role in the tumori...
Impact of COVID-19 pandemic on treatment patterns for stage I Non-Small Cell Lung Cancer in the Netherlands [0.03%]
COVID-19大流行对荷兰一期非小细胞肺癌治疗模式的影响
R M G van Vuren,N Wolfhagen,R A M Damhuis et al.
R M G van Vuren et al.
Introduction: The COVID-19 pandemic significantly impacted lung cancer treatment, necessitating shifts in treatment modalities. Guidelines temporarily recommended SBRT as alternative to surgery for early-stage NSCLC. ...
Illuminating the spectrum of genomic sequencing approaches in the precision oncology era: A UK perspective [0.03%]
照亮精准肿瘤学时代的基因组测序方法谱系：英国视角
Pasquale Rescigno,Alastair Greystoke
Pasquale Rescigno
Next-generation sequencing (NGS) offers broad molecular profiling that reveals genetic variation, gene expression and epigenetic modifications. This information is essential for identifying actionable biomarkers, enabling informed clinical ...
Preliminary study of androgen receptor expression in oral lichen planus and oral squamous cell carcinoma: A comparative cross-sectional analysis [0.03%]
口腔扁平苔藓和口腔鳞状细胞癌中雄激素受体表达的初步研究：一项比较性横断面分析
Shiva Shirazian,Saeide Tehranchi,Nazanin Mahdavi et al.
Shiva Shirazian et al.
Purpose: Androgen receptor (AR) signaling is known to contribute to the progression of various cancers, including oral squamous cell carcinoma (OSCC). However, its role in oral lichen planus (OLP), a chronic inflammatory ...
Huange Zhu,Burong Li,Jie Lu et al.
Huange Zhu et al.
Lung cancer is one of the most common types of cancer and the leading cause of cancer-related deaths worldwide, including China. Early-stage treatment involves anatomical lung resection, while advanced stages require chemotherapy or radioth...
Single-cell analysis of lung cancer metabolism and its clinical implications [0.03%]
单细胞分析肺癌代谢及其临床意义
Xinglong Li,Guangsong Tang,Wenyue Wang et al.
Xinglong Li et al.
Background: Lung cancer is a highly prevalent and invasive malignancy, characterized by profound metabolic reprogramming as one of its key features. The advent of single-cell RNA sequencing (scRNA-seq) has allowed us to s...
Serum ZFPL1 as a clinical biomarker for diagnosis, progression tracking, and treatment response in lung cancer [0.03%]
血清ZFPL1作为肺癌诊断、病情跟踪和治疗反应的临床生物标志物
Teng Yu,Honglin Liu,Yingxuan Chen et al.
Teng Yu et al.
Objective: Zinc finger protein-like protein 1 (ZFPL1) is a key protein involved in various biological processes such as cell growth, migration, proliferation, and metabolism. It plays a significant role in the development...
Exploring the application of PD-1/PD-L1 inhibitors for ovarian cancer [0.03%]
探索PD-1/PD-L1抑制剂在卵巢癌中的应用
Xinyu Miao,Zhenpeng Wang,Dongzhen Liu et al.
Xinyu Miao et al.
Ovarian cancer remains one of the leading causes of cancer-related mortality among women worldwide. Although standard treatment regimens, including cytoreductive surgery combined with platinum-based chemotherapy, have achieved certain thera...
Pharmacoinformatics-based screening of Capparis spinosa phytocompounds against pancreatic ductal adenocarcinoma by targeting TSPAN1 protein [0.03%]
基于药理信息学的筛选刺角瓜植物化合物针对胰腺导管腺癌中TSPAN1蛋白的作用研究
Hanieh Beyrampour-Basmenj,Morteza Hadizadeh,Abolfazl Doustmihan et al.
Hanieh Beyrampour-Basmenj et al.
Background: Today, phytochemicals have garnered significant attention due to their diverse pharmacological effects against various diseases, particularly cancer. Computer-aided drug design (CADD) is a time- and cost-effec...