RAS-variant allele frequency as a potential prognostic marker of overall survival in patients with metastatic colorectal cancer [0.03%]
RAS变异型等位基因频率作为转移性结直肠癌患者总生存率的潜在预后标志物的研究
Udit Nindra,Jun Hee Hong,Martin Hong et al.
Udit Nindra et al.
Background: Presence of RAS mutations in mCRC are negatively correlated with OS. NGS enables detailed information regarding the heterogeneity of RAS mutations including specific amino acid changes as well as variant allel...
Non-Coding RNAs in breast cancer bone metastasis: Regulators and novel therapeutic targets [0.03%]
非编码RNA在乳腺癌骨转移中的调控作用及作为潜在治疗靶点的作用
Yuanqing Yang,Xiaobing Li,Yongqiang Yin
Yuanqing Yang
Bone metastasis is one of the most common complications in patients with advanced breast cancer, severely impairing quality of life and significantly increasing the risk of mortality. This process is driven by complex interactions between t...
Efficacy and safety of first-line EGFR-TKI combined with chemotherapy versus EGFR-TKI monotherapy in patients with EGFR-mutant non-small cell lung cancer and liver metastases: A propensity score-matched analysis [0.03%]
一线EGFR-TKI联合化疗对比单药治疗EGFR突变非小细胞肺癌伴肝转移患者的疗效及安全性：倾向性评分匹配分析
Wen Zhang,Zhou Long,Xiaoli He et al.
Wen Zhang et al.
Introduction: Liver metastasis (LM) confers a poor prognosis in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). Although EGFR tyrosine kinase inhibitors (TKIs) are the stan...
Filip Ambrozkiewicz,Esraa Ali,Martina Bradova et al.
Filip Ambrozkiewicz et al.
Limited DNA sequencing data on lung cancer (LC) patients are available from Eastern Europe where male smoking is commonest in Europe. As sequence analysis is the prerequisite for targeted therapy we provide such data from Czechia (CZ). Addi...
Transcriptomic landscape of coexisting ovarian clear cell carcinoma and endometriosis: Insights into malignant transformation [0.03%]
共存卵巢透明细胞癌和子宫内膜异位症的转录组谱系：恶性转化的新见解
Mami Shibata,Yuji Kamei,Keisuke Kawamoto et al.
Mami Shibata et al.
This study investigateted the malignant transformation of endometriosis (EMS) into ovarian clear cell carcinoma (OCCC) using spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) integration. Tissues with coexisting EMS and OCC...
Application of landmark analysis and piecewise Cox regression to identify features associated with prognosis: A national retrospective cohort study of New Zealand women [0.03%]
应用地标分析和分段Cox回归识别与预后相关的特征：新西兰女性全国回顾队列研究的运用
B Woodhouse,W Laux,A Trevarton et al.
B Woodhouse et al.
Background: Breast cancer prognosis changes over time in complex ways depending on individual risk factors. This study aimed to analyze how breast cancer outcomes in New Zealand women change over time and identify feature...
Unraveling the potential of USP8 as a therapeutic target for overcoming c-Met-mediated resistance in breast cancer: A review [0.03%]
美国第八号独特性酶作为克服乳腺癌中c-Met介导的抵抗性的治疗靶点的潜力：综述
Doris Nnenna Amuji,Suleiman Zakari,Ayomikun Joshua Pirisola et al.
Doris Nnenna Amuji et al.
Therapeutic resistance remains a serious challenge in breast cancer, and abnormal c-mesenchymal epithelial transition factor (c-Met) receptor tyrosine kinase (RTK) activation contributes to therapeutic resistance in many. Ubiquitin-specific...
Contemporary insights into head and neck cancers: Epidemiology, molecular biology, diagnosis, and therapeutic advances [0.03%]
头颈癌的当代见解：流行病学、分子生物学、诊断和治疗进展
Ankit Singh
Ankit Singh
Head and Neck Cancers (HNCs) continue to pose significant challenges in oncology due to their complex heterogeneity and the persistent limitations of current therapeutic strategies, underscoring the critical need for contemporary, insightfu...
Comparative analysis of IHC, AMRS-PCR, and ddPCR for BRAF V600E mutation detection in papillary thyroid carcinoma [0.03%]
免疫组化、巢式多重逆转录定量 PCR 和数字滴度 PCR 检测乳头状甲状腺癌组织中BRAF V600E 突变的比较研究
Chen Chang,Guodong Fang,Jianyuan Lei et al.
Chen Chang et al.
Background: The BRAF V600E mutation is the most frequent driver alteration in papillary thyroid carcinoma (PTC) and plays an important role in diagnosis, risk stratification, and treatment planning. Commonly used detectio...
Efficacy evaluation of the 2017 protocol by the China Net Childhood Lymphoma in treating early T cell precursors-lymphoblastic lymphoma in pediatric patients [0.03%]
中国儿童淋巴瘤协作组2017版方案治疗小儿早期T细胞前体急性淋巴细胞白血病/淋巴瘤疗效评估
Huang Zhizhuo,Jin Ling,Liu Wei et al.
Huang Zhizhuo et al.
To analyze the clinical features of early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in pediatric patients and to summarize the efficacy evaluation of the 2017 protocol by the China Net Childhood Lymphoma (CNCL) No...