Gut microbiota regulating programmed cell death: Impacts on cancer immunotherapy, mechanisms, therapeutic responses and intervention strategies [0.03%]
肠道微生物群调节程序性细胞死亡：对癌症免疫治疗、机制、治疗反应和干预策略的影响
Tingfang Long,Yongai Xiong
Tingfang Long
Cancer is one of the leading causes of death worldwide, with millions of new cases and fatalities annually, imposing a heavy burden on global healthcare systems. Among the factors influencing antitumor efficacy, the host gut microbiota-a dy...
Engineering of ovine pancreatic RNase A as an Anti-tumor agent through in silico and experimental approaches [0.03%]
通过计算机模拟和实验方法工程改造绵羊胰腺RNase A作为抗肿瘤剂
Mahsa Zabetian,Marzieh Gharouni,Mohamadreza Nassiri et al.
Mahsa Zabetian et al.
Ovine RNase A (O-RNase A) is a promising candidate due to its effectiveness as a toxin. It is an effective variant of bovine RNase A, with four specific mutations (A19S, K37Q, V46F, and N103E). RNase A families are inhibited by RNase inhibi...
Harnessing tumor-agnostic biomarkers for precision medicine in lymphoma [0.03%]
利用肿瘤无关的生物标志物进行淋巴瘤的精准医疗
Yixuan Lee,Nicole-Ann Lim,Rowena Lee Ying Kwan et al.
Yixuan Lee et al.
Tumor-agnostic therapies focus on shared molecular biomarkers independent of tissue of origin, allowing a single drug to target a common biomarker across different tumor types. Such targets with regulatory drug approvals include NTRK fusion...
Distinct molecular features of ovarian adult granulosa cell tumors and co-occurring primary malignancies-an exploratory case series [0.03%]
成人颗粒细胞肿瘤及其并发原发性恶性肿瘤的分子特征探索性病例系列分析
Sven Karstensen,Tim Svenstrup Poulsen,Claus Høgdall et al.
Sven Karstensen et al.
Background: Ovarian adult granulosa cell tumor (aGCT) is a rare gynecological malignancy and has been associated with increased incidence of other primary malignancies, particularly endometrial. However, potential shared ...
Molecular determinants of Bortezomib sensitivity and resistance in multiple myeloma [0.03%]
硼替佐米敏感与耐药的多发性骨髓瘤的分子决定因素
Jahir Hossain,Debopriya Choudhury,Soham Bhattacharyya et al.
Jahir Hossain et al.
Bortezomib, a first-in-class proteasome inhibitor, has significantly transformed the therapeutic landscape of multiple myeloma (MM). Despite its clinical efficacy, both intrinsic and acquired resistance limit its long-term success. This rev...
Pharmacological approaches for colitis associated colorectal cancer: a survey in preclinical studies [0.03%]
基于临床前研究的溃疡性结肠炎相关结直肠癌药理学干预手段探讨
Erfan Abdollahizad,Anna Meyfour
Erfan Abdollahizad
Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease (IBD), characterized by a unique inflammation-driven pathogenesis that distinguishes it from sporadic colorectal cancer. Despite advances in d...
Association of glucagon-like peptide 1 receptor and the aggressiveness of extrahepatic cholangiocarcinoma [0.03%]
GLP-1受体与胆管癌侵袭性的相关性研究
Yongyot Varathorn,Mathawee Chanamarnjuntho,Ronnakrit Trakoonsenathong et al.
Yongyot Varathorn et al.
Previous studies demonstrated that the suppression of GLP-1R expression significantly reduced the aggressiveness of intrahepatic cholangiocarcinoma (iCCA) cells, in vitro and in vivo. However, the clinical significance of GLP-1R in extrahep...
The microbiome-epigenome axis: Regulation of host genome function across development and disease [0.03%]
微生物组-表观基因组轴：发育和疾病过程中对宿主基因组功能的调控
Qamar Abuhassan,Ali M Atoom,Subbulakshmi Ganesan et al.
Qamar Abuhassan et al.
The gut microbiome is increasingly recognized as a metabolically active regulator of host gene expression, translating environmental exposures-particularly diet-into epigenetic signals that shape development, immunity, metabolism, and disea...
A comparative analysis of cytotoxic effects: Lactobacillus reuteri Extract vs. Newcastle Disease Virus in human colorectal cancer (HT-29 cell line) [0.03%]
乳酸菌雷特氏菌提取物与新城疫病毒的细胞毒性比较分析：以人结直肠癌HT-29细胞系为研究对象
Ali Nemani Khiavi,Mohammad Hossein Lahimchi,Ashkan Mashaheri Fard et al.
Ali Nemani Khiavi et al.
Background: Colorectal cancer (CRC) remains a major global health burden. Standard therapies, including surgical removal and chemotherapy, can cause significant complications such as fatigue and nausea. This research eval...
The influence of CD117, CD133, CD24, CD44, and ALDH expression on progression-free survival in advanced-stage epithelial ovarian cancer patients [0.03%]
CD117、CD133、CD24、CD44和ALDH表达对晚期上皮性卵巢癌患者无进展生存期的影响
Kade Yudi Saspriyana,I Nyoman Gede Budiana,Novi Silvia Hardiany et al.
Kade Yudi Saspriyana et al.
Objective: Cancer stem cell (CSC) markers are increasingly recognized as key indicators for tumour aggressiveness, chemoresistance, and recurrence in epithelial ovarian cancer (EOC). This study aimed to evaluate the expre...