Immune Checkpoint Inhibitor Outcomes Across Child-Pugh A, B, and C Hepatocellular Carcinoma: A Real-World Integrated Health-System Cohort [0.03%]
基于Child-Pugh分级的免疫检查点抑制剂治疗肝细胞癌疗效：来自综合健康系统队列的真实世界证据
Alireza Tojjari,Yuming Shi,Stela Celaj et al.
Alireza Tojjari et al.
Background: Pivotal first-line immune checkpoint inhibitor (ICI) trials in advanced hepatocellular carcinoma (HCC) largely restricted enrollment to patients with Child-Pugh A liver function, leaving outcomes in patients w...
PPARγ activation sensitizes MSS gastrointestinal cancer cells to PD1 blockage [0.03%]
PPARγ激活使微卫星稳定型胃肠癌细胞对PD1阻断敏感化
Juliane Reichling,Beifang Li,Yanxiong Yu et al.
Juliane Reichling et al.
Objectives: Antibodies (Abs) against immune checkpoint "programmed-cell-death-1" (PD1) achieve benefit in patients with microsatellite instable (MSI), immunologically "hot" gastrointestinal (GI) cancers, but fail in cases...
Prevalence of cancer-related fatigue after treatment in patients with non-metastatic gastrointestinal cancers [0.03%]
非转移性消化系统肿瘤患者治疗后的癌因性疲乏发生率
Siavash Soleymani,Safoora Nikzad,Maryam Hasanzarrini et al.
Siavash Soleymani et al.
Background: Cancer-related fatigue (CRF) is a prevalent and distressing symptom that persist long after treatment, significantly diminishing the quality of life in cancer survivors-particularly those with gastrointestinal...
Key target genes of miR-625-5p in colorectal cancer: uncovering novel therapeutic targets within regulatory network [0.03%]
miR-625-5p在结直肠癌中的关键靶基因：揭示调控网络中潜在新治疗靶点
Hamed Manoochehri,Mohammad Javad Mousavi,Amirhossein Darabi et al.
Hamed Manoochehri et al.
Background: Colorectal cancer (CRC) is usually diagnosed when therapeutic options are limited, highlighting the need for novel molecular targeted therapies. MicroRNAs, as important regulators in cancer-related pathways, m...
Local ablative treatment and continuation of systemic therapy for oligoprogressive metastatic breast cancer: a retrospective cohort study [0.03%]
寡进展性转移性乳腺癌的局部消融治疗及继续全身治疗：一项回顾性队列研究
Cornelia A M Almekinders,Tess I M Snellen,Annemiek van Ommen-Nijhof et al.
Cornelia A M Almekinders et al.
Introduction: Patients with metastatic breast cancer (MBC) typically receive palliative systemic therapy until unmanageable toxicity or progression, at which point treatment is changed. However, this approach may be subop...
Assessment of national cancer care network guideline-adherent treatment differences as a contributor to racial disparities in epithelial and non-epithelial ovarian cancer survival [0.03%]
评估国家癌症护理网络指南依从性治疗差异对上皮性和非上皮卵巢癌生存率种族差距的贡献
Marilyn Barragan,Shannon MacLaughlan David,Zhengia Chen et al.
Marilyn Barragan et al.
Objective: To assess National Comprehensive Cancer Network (NCCN) guideline concordance and survival for epithelial and nonepithelial ovarian cancer in Black and White patients. Guideline-concordant care is defined as tre...
Santosh Tummidi,Kanchan Kothari,Puneeta Nagiredla et al.
Santosh Tummidi et al.
Background: The cell block technique enhances sample adequacy in FNA specimens by enabling retrieval of small tissue fragments that can be processed into paraffin blocks for ancillary tests. ...
Beyond hyponatremia: serum sodium below 137 mEq/L and postoperative sodium trajectory as prognostic markers in resected non-small cell lung cancer [0.03%]
低钠血症之外：血清钠低于137mEq/L和术后钠水平变化作为肺癌的预后标志物
Seyda Ors Kaya,Kenan Can Ceylan,Serap Yıldız et al.
Seyda Ors Kaya et al.
Background: Clinical hyponatremia (serum sodium
Lymphatic extracellular vesicles and non-coding rnas in the melanoma sentinel lymph node pre-metastatic niche: Emerging lessons from aggressive skin cancers [0.03%]
黑色素瘤转移前生态龛中的淋巴管来源的细胞外囊泡和非编码RNA：来自侵袭性皮肤癌的新认识
Mustafa T Ardah,Umida Tashkenbaeva,Abdulqader Faris Abdulqader et al.
Mustafa T Ardah et al.
Sentinel lymph node (SLN) involvement remains one of the strongest prognostic markers in cutaneous melanoma; however, the SLN is not merely a staging specimen. It is the first organized immune-stromal site exposed to lymph-borne melanoma-de...
Survival outcomes in EGFR-mutant versus wild-type locally advanced non-small cell lung cancer treated with definitive chemoradiotherapy alone in the pre-PACIFIC/LAURA trial era: A systematic review and meta-analysis using reconstructed individual patient data [0.03%]
EGFR突变型与野生型局晚期非小细胞肺癌患者在PACIFIC/LAURA试验前仅接受根治性同步放化疗的生存结局：基于重建个体患者数据的系统评价和Meta分析
Satoru Ochiai,Takamitsu Mase,Yutaka Toyomasu et al.
Satoru Ochiai et al.
Background and aims: This study evaluated the prognostic impact of epidermal growth factor receptor (EGFR) mutations in locally advanced non-small cell lung cancer (NSCLC) treated with definitive chemoradiotherapy (CRT) a...