Synergistic regulation of tumor angiogenesis via flavonoid modulation of lncRNAs: Mechanistic insights and therapeutic potential [0.03%]
黄酮通过调控长链非编码RNA协同调节肿瘤血管生成：机制与治疗潜力
Akanksha Gupta,G S N Koteswara Rao,Hardeep Singh Tuli et al.
Akanksha Gupta et al.
Angiogenesis is a hallmark process of tumor growth, metastatic progression, and therapeutic resistance. The role of long noncoding RNAs (lncRNAs) in the regulation of angiogenesis has emerged as a critical factor influencing cancer progress...
OTUB1/SLC7A11 axis promoted AKT signaling activation to mediate ovarian cancer progression [0.03%]
OTUB1/SLC7A11轴促进AKT信号激活以介导卵巢癌进展
Yujin Zhang,Jing Wang,Sensen Sun et al.
Yujin Zhang et al.
Purpose: OTUB1 functions as a deubiquitinating enzyme (DUB) and has been reported to be associated with tumor progression. This study aimed to investigate the role of OTUB1 signaling in ovarian cancer progression. ...
Chemotherapy-induced liver injury in Tibetan breast cancer patients: clinical features and risk factor analysis [0.03%]
藏族乳腺癌患者化疗性肝损伤的临床特征及危险因素分析
Quzhen Ciren,Zhen Se,Wangmu Sangdan et al.
Quzhen Ciren et al.
Objective: To conduct the first analysis of the clinical characteristics and factors affecting drug-induced liver injury following neoadjuvant and adjuvant chemotherapy for breast cancer in the Xizang region. ...
Dual-jet transition cold atmospheric plasma suppresses colon cancer stem cells via matrix metalloproteinase regulation [0.03%]
双喷射冷等离子体通过基质金属蛋白酶抑制结直肠癌干细胞
Abolfazl Soulat,Taghi Mohsenpour,Leila Roshangar
Abolfazl Soulat
Colon cancer stem cells (CCSCs) are critical drivers of tumor progression, metastasis, and therapeutic resistance, largely mediated by matrix metalloproteinases (MMPs). This study investigates the therapeutic potential of a novel dual-jet t...
Efficacy of pembrolizumab plus pemetrexed in older patients with non-squamous NSCLC according to PD-L1 expression status: Results from the CJLSG1901 study [0.03%]
根据PD-L1表达状态评估培美曲塞联合帕博利珠单抗治疗非鳞状非小细胞肺癌老年患者疗效：CJLSG1901研究结果
Yoshihito Kogure,Hiroya Hashimoto,Satoshi Ikeda et al.
Yoshihito Kogure et al.
Background: The CJLSG1901 phase 2 study evaluated efficacy and safety of pembrolizumab plus pemetrexed in older populations. A novel first-line approach for older patients with metastatic non-squamous non-small cell lung ...
Characterization of POU2F3-expressing large cell neuroendocrine carcinoma of the lung: A comprehensive analysis of morphology, immunohistochemistry, and genomic alterations [0.03%]
POU2F3表达型肺大细胞神经内分泌癌的特征：形态学、免疫组化和基因组改变的综合分析
Ryota Matsuoka,Kei Asayama,Tomoki Nakagawa et al.
Ryota Matsuoka et al.
Large cell neuroendocrine carcinoma (LCNEC) is a neuroendocrine carcinoma (NEC) of the lung that is characterized by its heterogeneous morphology, diverse immunophenotypes, and complex genomic profiles. Among LCNECs, a subset expressing the...
Prognostic role and clinicopathological features of SMAD4 gene mutation in pancreatic cancer: a systematic review and meta-analysis [0.03%]
胰腺癌中SMAD4基因突变的预后作用及临床病理特征：系统评价和meta分析
Tânia Rodrigues,Joana Albuquerque,Joana Cardoso et al.
Tânia Rodrigues et al.
Purpose: The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the prognostic value of the SMAD4 gene in p...
Jiaxue Zhu,Jianru Xiao
Jiaxue Zhu
Leucine-rich repeat-containing protein 15 (LRRC15), a transmembrane protein, has been closely associated with malignant phenotypes, therapeutic resistance, and immune evasion in various solid tumors since its initial identification as a tum...
Comprehensive clinical characteristics and outcomes of stage IV EGFR-mutant NSCLC based on PD-L1 expression [0.03%]
基于PD-L1表达的IV期EGFR突变型NSCLC的临床特征和结果综合分析
Jonathan W Lee,Xiao Jin,Stephanie Bogdan et al.
Jonathan W Lee et al.
Epidermal growth factor receptor (EGFR) and programmed death ligand 1 (PD-L1) are cell surface proteins that interact in the context of immune evasion to promote cancer growth. Associations between PD-L1 expression level and clinico-patholo...
Coconut milk exosomal formulation of curcumin analog targets head and neck cancer progression through alterations in the HABP1 signaling mechanism [0.03%]
椰奶乳状.curcumin类似物类通过HABP1信号机制的改变靶向头颈部癌症进展
Kaumudi Pande,Bettadaiah B K,Anbarasu Kannan
Kaumudi Pande
Background: Head and neck cancer (HNC) is a malignancy characterized by uncontrolled cell growth with increasing incidence rates and heterogeneity. Hyaluronan binding protein 1 (HABP1) is a glycoprotein that acts as a cel...