Cholesteryl ester and cholesterol as candidate biomarkers for differentiating primary lung squamous cell carcinoma from head and neck squamous cell carcinoma; proof-of-concept biomarker study [0.03%]
胆固醇酯和胆固醇作为区分原发性肺鳞状细胞癌与头颈部鳞状细胞癌的候选生物标志物的概念验证研究
Takamitsu Hayakawa,Yusuke Takanashi,Minako Kondo et al.
Takamitsu Hayakawa et al.
Introduction: Distinguishing primary lung squamous cell carcinoma (PLSCC) from pulmonary metastases of head and neck squamous cell carcinoma (HNSCC) is clinically critical because treatment strategies differ. However, exi...
Curcumin as a natural photosensitizer in photodynamic therapy: efficacy against metastatic melanoma cells [0.03%]
光动力疗法中的姜黄素类天然光敏剂及其对转移性黑色素瘤的疗效研究
Aishat Adejoke Obalola,Heidi Abrahamse,Sathish Sundar Dhilip Kumar
Aishat Adejoke Obalola
Malignant melanoma is one of the most aggressive and lethal forms of skin cancer, posing a significant global health challenge. Despite therapeutic advances, current treatment strategies remain limited in efficacy, highlighting the need for...
Fumarate hydratase-deficient renal cell carcinoma - results of the exploratory analysis in the SUNNIFORECAST trial comparing Ipilimumab plus Nivolumab vs standard of care as first line treatment [0.03%]
SUNNIFORECAST试验探索性分析： ipilimumab联合nivolumab对比标准治疗作为透明细胞型富马酸水合酶缺陷肾癌一线治疗的疗效和安全性
Marit Ahrens,John Haanen,Laurence Albiges et al.
Marit Ahrens et al.
Background: Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare, molecularly defined subgroup of non-clear cell RCC (nccRCC) lacking an approved standard treatment. We report the exploratory analysis of...
The potential role of oligo-fucoidan as a bioactive adjunct in oncology: a personal view on mechanistic insights and therapeutic continuity [0.03%]
寡岩藻糖作为肿瘤生物活性佐剂的潜在作用：对机制见解和治疗连续性的个人观点
Kuan-Chou Lin,Jung-Min Yu,Chia-Lun Chang et al.
Kuan-Chou Lin et al.
Despite the evolution of targeted therapies, the clinical efficacy of multimodal treatments is frequently constrained by a persistent 'therapeutic ceiling', where dose-limiting toxicities necessitate involuntary interruptions in 20%-25% of ...
Circulating tumor DNA to predict the risk of venous thromboembolism in locally advanced rectal cancer [0.03%]
循环肿瘤DNA预测局部晚期直肠癌静脉血栓栓塞风险
Lorenzo Gervaso,Davide Ciardiello,Samuele Frassoni et al.
Lorenzo Gervaso et al.
Background: Venous thromboembolism (VTE) is a common complication in cancer patients and negatively affects prognosis. Colorectal cancer (CRC) has the second highest incidence of VTE among the four most common cancers. In...
Exploring decisional needs of adults considering first line treatment for advanced EGFR+ lung cancer: An interpretive descriptive study [0.03%]
一项解释性描述研究：探索EGFR阳性晚期肺癌一线治疗患者决策需求
Rena Seeger,Dawn Stacey,Emi Bossio et al.
Rena Seeger et al.
Background: With expanding treatment options for EGFRs+ metastatic non-small cell lung cancer (mNSCLC), shared decision-making is critical in aligning treatment plans with patient values. Oral targeted therapies offer con...
Titilope M Dokunmu,Faith C Nnaji,Doris N Amuji et al.
Titilope M Dokunmu et al.
Breast Tumour Kinase (BRK/PTK6) is a non-receptor tyrosine kinase that has attracted growing interest in breast cancer research due to its association with tumour progression, aggressive disease behaviour, therapy resistance, and prognosis....
Gaps in awareness, misconceptions, and cultural barriers to breast cancer care: community and stakeholder perspectives from Southern Ethiopia: a qualitative study [0.03%]
关于乳腺癌诊疗的意识不足、认识误区及文化障碍——来自埃塞俄比亚南部社区和利益攸关方的观点：定性研究
Bargude Balta
Bargude Balta
Introduction: Breast cancer is a major global public health concern, with Ethiopia facing distinctive barriers that hinder timely care. Challenges include limited access to healthcare, inadequate information, infrastructu...
Opium and opioid use and cancer risk: A systematic review and meta-analysis of epidemiological studies [0.03%]
鸦片和阿片类药使用与癌症风险的系统评价和meta分析研究
Kiavash Semnani,Behnaz Ghoreshi,Omid Mehrpour et al.
Kiavash Semnani et al.
Opium use has been suggested as a possible risk factor for several cancers. While increased risk may be attributable to adulterants or smoking by-products, direct effects for opium alkaloids remains a possibility. Considering the overlap be...
Performance status 2 or higher in EMA labels for advanced non-small-cell lung cancer: a cross-sectional SmPC analysis [0.03%]
EMA标签中非小细胞肺癌二线或后线治疗适应症的体能评分要求：基于SmPC的横断面分析研究
Javier-David Benitez-Fuentes,Elena Navarro Vicente,Antonio David Lazaro Sanchez et al.
Javier-David Benitez-Fuentes et al.
Background: Advanced NSCLC patients with ECOG PS ≥2 are common, under-represented in pivotal trials, and have inferior outcomes with immune checkpoint inhibitors. EU label coverage for ECOG PS ≥2 and PS-based dosing gui...