Initial treatment patterns and survival in biliary tract cancer: A retrospective cohort study in Kyoto, Japan [0.03%]
一项在日本京都进行的关于胆道癌初始治疗模式和生存率的回顾性队列研究
Yukiko Tateyama,Sachiyo Shirakawa,Makoto Namba et al.
Yukiko Tateyama et al.
Purpose We aimed to describe the treatment landscape for biliary tract cancer (BTC), including patient characteristics, initial treatment patterns, and survival outcomes, and examine factors associated with receiving no active anticancer tr...
Rac/Cdc42 inhibitors target pancreatic cancer cells and macrophages in the tumor microenvironment [0.03%]
Rac/Cdc42抑制剂靶向胰腺癌细胞和肿瘤微环境中的巨噬细胞
Anamaris Torres-Sanchez,Stephanie Dorta-Estremera,Victor P Carlo et al.
Anamaris Torres-Sanchez et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest forms of cancer, with a distinct extracellular matrix and immunosuppressive tumor microenvironment. Therefore, there is a critical need for therapies that simultaneously t...
Concurrent preoperative eribulin and radiation for resectable retroperitoneal liposarcoma: a phase 1B study [0.03%]
局部晚期腹膜后脂肪肉瘤术前依立替康联合放疗的Ib期临床研究
Lara E Davis,Limin Zhu,Skye C Mayo et al.
Lara E Davis et al.
Background: Management of retroperitoneal liposarcoma (RPLPS) is challenging and recurrence rates remain high despite aggressive surgical resections. Preoperative radiation alone lacks definitive benefit, thus we sought t...
Comprehensive molecular profiling of advanced NSCLC in Greek patients:A prospective HeCOG study [0.03%]
希腊患者晚期非小细胞肺癌综合分子分型研究：HeCOG前瞻式研究
Paris A Kosmidis,Thanos Kosmidis,Kyriaki Papadopoulou et al.
Paris A Kosmidis et al.
Background: We report for the first time the molecular landscape and outcome associations from the prospective CLIMEDIN trial in Greece. Methods: ...
Immunogenic effects of hyperthermia in an experimental model of peritoneal metastases of colorectal cancer enhance tumor susceptibility to immunotherapy [0.03%]
通过结直肠癌腹膜转移实验模型探讨高温的免疫效应及其增强肿瘤对免疫治疗敏感性的作用
Michael Tasker,Jawad Tome,Ronny Uzana et al.
Michael Tasker et al.
Background: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves outcomes in selected patients with peritoneal metastases from colorectal cancer (PM-CRC) but is associated with signi...
Immune checkpoint inhibitor (ICI) associated corneal allograft rejection [0.03%]
免疫检查点抑制剂(ICIs)相关角膜移植排斥反应
Philip Marjon,Julio Echegoyen,David J Schanzlin et al.
Philip Marjon et al.
This paper highlights a potential immune mediated effect of ICI's that is not well appreciated. The rejection of a corneal allograft with loss of vision should be taken into account in the treatment of these patients. RELEVANCE: With the ra...
Systemic immune-inflammation index as a prognostic marker in pancreatic ductal adenocarcinoma: a metaanalysis [0.03%]
系统免疫炎症指数可作为胰腺导管腺癌的预后标志物：一项荟萃分析
Bence Pachinger-Molnár,Otília Menyhárt
Bence Pachinger-Molnár
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited durable treatment options despite evolving multimodal and systemic strategies. Systemic inflammation has emerged as a clinical...
Association of apolipoprotein A2 isoform index with demographic, behavioral, and clinical risk factors for pancreatic ductal adenocarcinoma in a single-center observational study: considerations for development of a pancreatic cancer screening algorithm? [0.03%]
单中心观察性研究中载脂蛋白A2亚型指数与胰腺导管腺癌人口学、行为和临床风险因素的相关性：开发胰腺癌筛查算法的考虑因素？
Alan H B Wu,Chui Mei Ong,Melissa Alamillo et al.
Alan H B Wu et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality rates therefore early diagnosis and treatment is essential in reducing mortality. Blood tests that can identify high-risk individuals i...
Pinkbar elevation in colon cancer patients and the therapeutic effects of hAMSCs secretome through AKT/mTOR and Wnt3a/β-catenin signaling pathways in HT-29 colon cancer cells [0.03%]
结直肠癌患者中Pinkbar高表达及人胎盘间充质干细胞分泌组对HT-29结直肠癌细胞AKT/mTOR和Wnt3a/β-catenin信号通路的干预作用研究
Fatemeh Safari,Danial Hassas Khodravesh,Nasim Shafiee Nejad et al.
Fatemeh Safari et al.
Cancer is a major cause of human death. Colon cancer is the fifth leading cause of cancer-related deaths worldwide. Pinkbar, a member of the inverse BAR (I-BAR) domain protein subfamily, is associated with the actin cytoskeleton, leading to...
A population-based analysis of the elective surgical management for non-metastatic splenic flexure cancers, the ongoing question [0.03%]
非转移性乙状结肠癌的择期手术管理模式分析——一个亟待解决的问题
Ahmed Zeid,Mariana Morales-Cruz,Ahmed Almonib et al.
Ahmed Zeid et al.
Aim and background: Malignancies found at the splenic flexure correspond to only 2-4% of all colorectal cancers and no standardised surgical technique exists for its treatment. Our study analyses the surgical and oncologi...