Therapy gone viral: Exploring the use of oncolytic viruses in non-small cell lung cancer immunotherapy [0.03%]
疗效显著：探讨溶瘤病毒在非小细胞肺癌免疫治疗中的应用
Jemima Steele,Emma Taylor,Sawsan Khuri et al.
Jemima Steele et al.
Non-small cell lung cancer is a significant cause of cancer-related death worldwide. Current treatment modalities for advanced-stage non-small cell lung cancer can be intrusive, with limited efficacy and unfavourable side effect profiles. H...
First-line durvalumab plus platinum-etoposide in Japanese patients with extensive-stage small-cell lung cancer [0.03%]
德瓦鲁单抗联合顺铂和依托泊苷治疗广泛期小细胞肺癌的日本患者：关键3期CASPIAN试验的事后亚组分析
Eisuke Mochizuki,Shun Matsuura,Naoki Koshimizu et al.
Eisuke Mochizuki et al.
Background: Platinum-based chemotherapy combined with immune checkpoint inhibitor therapy has recently been introduced for treating extensive-stage small-cell lung cancer (ES-SCLC). In the Phase III CASPIAN study, first-l...
A systematic literature review of MTAP deletions in solid and hematologic Cancers [0.03%]
MTAP基因缺失在实体瘤和血液系统肿瘤中研究的系统性文献回顾
Mary C Clouser,Mina Suh,Naimisha Movva et al.
Mary C Clouser et al.
Background: Methylthioadenosine phosphorylase (MTAP) deficiency is observed across multiple cancers and represents an emerging biomarker with therapeutic potential via synthetic lethality with PRMT5 inhibition. This syste...
Central obesity increases the risk of breast cancer irrespective of menopausal status in women: Systematic review and meta-analysis [0.03%]
中心性肥胖会增加女性乳腺癌的患病风险：系统综述和荟萃分析
Aboma Motuma,Ibsa Mussa,Alemayehu Deressa et al.
Aboma Motuma et al.
Background: The incidence of breast cancer increased over the last few decades, however, it is less known about the relationship between central obesity and breast cancer incidence irrespective menopause. Given the increa...
Peripheral blood cells as prognostic markers in patients with advanced non-small cell lung cancer treated with cemiplimab as monotherapy or in combination with chemotherapy [0.03%]
新药Cemiplimab治疗晚期非小细胞肺癌的外周血生物标志物研究
Rolando J Acosta,Debra A G McIntyre,Joseph C Murray et al.
Rolando J Acosta et al.
Background: Patients with a high neutrophil/lymphocyte ratio (NLR) have poor prognosis in non-small cell lung cancer (NSCLC). Limited data are available on the contribution of other immune cells. This analysis assessed th...
Assessment of efficacy, safety, and prognostic/predictive factors of nintedanib/docetaxel in advanced/recurrent non-small cell lung cancer post-immunotherapy and chemotherapy: A Galician Lung Cancer Group study [0.03%]
尼拉类酶胺/多西他赛治疗免疫和化疗后进展的晚期肺腺癌疗效、安全性及预后/预测因素评估：加利西亚肺癌研究小组的一项研究
Natalia Fernández Núñez,Martín Lázaro Quintela,Jorge García González et al.
Natalia Fernández Núñez et al.
Introduction: Patients with advanced non-small cell lung cancer (NSCLC) who progress after chemotherapy and immune checkpoint inhibitors (ICIs) need effective second-line treatments. The combination of nintedanib and doce...
Serum Klotho: Unraveling its association with diagnosis and prognosis of breast cancer [0.03%]
血清Klotho与乳腺癌诊断和预后的相关性研究
K M Renu,Abhinay Kumar Singh,Masroor Anwar et al.
K M Renu et al.
Background: Klotho, an antioxidant protein, suppresses oxidative stress and its potential role in cancer due to shared molecular hallmarks with aging. The expression of Klotho in breast cancer (BC) tissue and circulation ...
Fibroblast activation protein-expression in colorectal carcinomas and implications for clinical application [0.03%]
纤维活化蛋白在结直肠癌中的表达及临床应用意义分析
Meaghan Polack,Gabi W van Pelt,Augustinus S L P Crobach et al.
Meaghan Polack et al.
Background: Colorectal cancer is highly prevalent. The stromal tumour microenvironment significantly influences tumour behaviour, and cancer-associated fibroblasts (CAFs), as major component of tumour stroma, are increasi...
Mitigating the side effects of conventional radiotherapy: deep examination of the FLASH effect on human healthy bronchial epithelial cell line [0.03%]
闪络效应减轻常规放射治疗的副作用：对人支气管上皮细胞系的深入研究
Francesca Del Debbio,Maria Sofia Bertilacchi,Andrea Cavalieri et al.
Francesca Del Debbio et al.
Lung cancer is the second leading cause of cancer-related deaths. Treatment based on conventional radiotherapy often results in severe side effects, such as pulmonary fibrosis, a fatal and untreatable condition. FLASH radiotherapy is an eme...
Evaluating the tozzi classification system in diaphragm surgeries for advanced ovarian cancer: Clinical applicability and perioperative outcomes [0.03%]
托奇分类系统在晚期卵巢癌膈肌手术中的临床应用及围术期结局评估
Divya Panyam Vuppu,Priya Bhati,Saumya Gupta et al.
Divya Panyam Vuppu et al.
Background: Over 70 % of advanced ovarian cancer cases involve metastasis to the peritoneum, diaphragm, and liver. Standardised diaphragm surgeries are vital for achieving complete cytoreduction and enhancing patient prog...