Osimertinib retreatment for patients with advanced EGFR-mutated non-small cell lung cancer [0.03%]
用于接受过表皮生长因子受体突变的晚期非小细胞肺癌患者的奥希替尼再挑战治疗
Kevin M Levine,Natalie F Uy,Ted A Gooley et al.
Kevin M Levine et al.
Resistance to osimertinib, a third-generation EGFR tyrosine kinase inhibitor, remains a key challenge in the treatment of EGFR-mutated non-small cell lung cancer (NSCLC). Although retreatment with earlier-generation EGFR tyrosine kinase inh...
Impact of aromatase inhibitors on thyroid function in postmenopausal women with early-stage breast cancer: a prospective controlled study [0.03%]
芳香化酶抑制剂对早期乳腺癌绝经后妇女甲状腺功能影响的前瞻性对照研究
Djordje Marina,August Nielsen,Kristian Buch-Larsen et al.
Djordje Marina et al.
Purpose: Aromatase inhibitors are commonly used in adjuvant therapy for breast cancer. However, their impact on thyroid function remains unclear. This study aimed to evaluate thyroid function in postmenopausal women with ...
Optimized cancer gene selection using armadillo optimization algorithm and support vector machine [0.03%]
基于Y突胸龟优化算法和支持向量机的癌症基因优选方法研究
Abrar Yaqoob,Mushtaq Ahmad Mir,Mohd Asif Shah
Abrar Yaqoob
Background: Feature selection is a crucial step in improving classification performance for high dimensional cancer datasets, which often contain numerous irrelevant or redundant features that can negatively impact model ...
Anne Quinn-Young,Michael Andreini,Arianna Haynes et al.
Anne Quinn-Young et al.
Direct-to-patient (DTP) research offers promising alternatives to traditional models, potentially improving population-level data collection to understand disease initiation, progression, and response to treatment. Recent reports and commen...
RUVBL1: A promising prognostic indicator for HPV-associated oral squamous cell carcinoma [0.03%]
RUVBL1：HPV相关口腔鳞状细胞癌预后标志物的希望携带者
Shyamaladevi Babu,Madhan Krishnan
Shyamaladevi Babu
Retrospective database analysis to assess treatment patterns, clinical outcomes, and healthcare resource utilization in metastatic or recurrent HER2-positive breast cancer in Alberta [0.03%]
回顾性数据库分析评估HER2阳性转移或复发乳腺癌在阿尔伯塔的治疗模式、临床结局和卫生资源利用情况
Robert B Basmadjian,Winson Y Cheung,Devon J Boyne et al.
Robert B Basmadjian et al.
Background: Population-based data from real-world sources on metastatic breast cancer (mBC) patient outcomes by HER2 status are limited, particularly in Canada. To meet this need, we examined treatment patterns, outcomes,...
TAMs-derived IL-1β inducing DDX21 enhances CRC proliferation and metastasis via JAK2/STAT3 pathway [0.03%]
肿瘤相关巨噬细胞衍生的白介素-1β通过诱导DDX21增强结直肠癌增殖和转移的作用及机制研究
Yu Wang,Tiantian Zhen,Shujin He et al.
Yu Wang et al.
Background: Tumor-associated macrophages (TAMs) are major components of tumor microenvironment that frequently associated with proliferation and metastasis in colorectal cancer (CRC). Our recent study found that DDX21 pro...
Artificial intelligence-based pharmacological approach in non-small cell lung cancer in the precision medicine era [0.03%]
精准医疗时代基于人工智能的非小细胞肺癌药理学方法研究
Stefano Fogli,Alessandro Barberis,Marzia Del Re et al.
Stefano Fogli et al.
The increasing knowledge in the molecular pathophysiology of non-small-cell lung cancer (NSCLC) allowed early identification of druggable targets; however, the advanced disease remains incurable mainly due to drug resistance. Therefore, it ...
Machine learning-based radiomics analysis on contrast-enhanced MRI for prediction of cytotoxic T-lymphocyte associated protein 4 expression in patients with breast cancer [0.03%]
基于机器学习的对比增强MRI影像组学分析在预测乳腺癌患者细胞毒性T淋巴细胞相关蛋白4表达中的应用
Xiaojie Wang,Huiyu Xiao,Lina Zhang et al.
Xiaojie Wang et al.
Background: Cytotoxic T-lymphocyte Associated Protein 4 (CTLA4) has been considered as a well-recognized immune checkpoint. The present study aimed to establish radiomics-based models to predict the CTLA4 expression level...
Harnessing nanotechnology for efficient delivery of indole-based drugs in cancer treatment [0.03%]
利用纳米技术高效递送吲哚类药物在癌症治疗中的应用
Nutan Shukla,Ratnesh Das,Aayushi Chanderiya et al.
Nutan Shukla et al.
Indole-based compounds represent an important class of bioactive molecules with proven anticancer potential. However, their clinical translation is hindered by poor solubility, rapid metabolism, systemic toxicity, and limited tumor penetrat...