The long-term trends in the disease burden of acute Lymphoblastic Leukemia in China from 1990 to 2021 and projections for the next 15 years [0.03%]
中国急性淋巴细胞白血病疾病负担的长期趋势（1990-2021年）及未来15年的预测
Dameng Zhang,Shan An,Xiangyu Dong et al.
Dameng Zhang et al.
Background: This study examines the burden of acute lymphoblastic leukemia (ALL) in China from 1990 to 2021 and predicts future trends over the next 15 years. ...
miR-150 in cancer metastasis: Orchestrating migration, invasion, and angiogenesis through context-dependent mechanisms [0.03%]
miR-150在癌症转移中的作用：通过上下文依赖机制协调迁移、侵袭和血管生成
Belal Almajali,Waleed K Abdulsahib,S Renuka Jyothi et al.
Belal Almajali et al.
Metastasis, which accounts for approximately 90 % of cancer-related mortality, is driven by intricate regulatory networks that remain only partially understood. MicroRNA-150 (miR-150) has emerged as a pivotal, context-dependent regulator wi...
Neoadjuvant FOLFOXIRI for locally advanced rectal cancer: A retrospective analysis focusing on long-term anal preservation [0.03%]
新辅助FOLFOXIRI治疗局部晚期直肠癌：长期保肛的回顾性分析
Ryohei Shoji,Fuminori Teraishi,Yuki Matsumi et al.
Ryohei Shoji et al.
To investigate the safety and efficacy of FOLFOXIRI as neoadjuvant chemotherapy (NAC) for locally advanced rectal cancer (LARC). The outcomes of preoperative and perioperative treatments, as well as long-term outcomes, were retrospectively ...
Cutting-edge drug resistance analysis of major cancers at single-cell level [0.03%]
基于单细胞水平的主要癌症的最新药耐受性分析方法
Tianyu Liu,Zhiyuan Cao,Wenxin Long et al.
Tianyu Liu et al.
Drug resistance, which means cancer cells are resistant to treatments, has been a major problem in cancer treatment. While drug tolerance which defines the long survival of cancer cells could be a possible reason, analyzing the sources and ...
Comprehensive review on outcomes from Phase 3 clinical trials of drugs in multiple myeloma [0.03%]
治疗多发性骨髓瘤药物III期临床试验结果的综合回顾分析
Sandeep Singh,Vivek Uttam,Shafiul Haque et al.
Sandeep Singh et al.
Multiple myeloma (MM) is a clonal plasma cell malignancy characterized by clinical heterogeneity, high relapse rates, and eventual drug resistance despite advances in therapy. Over the past two decades, phase 3 clinical trials have redefine...
Immunohistochemical analysis of thyroid transcription factor-1 in type A and AB thymomas comparing multiple primary antibody clones [0.03%]
不同类型胸腺瘤甲状腺转录因子-1的免疫组化多克隆抗体对比分析
Ayaka Mitsui,Jumpei Kashima,Satsuki Kishikawa et al.
Ayaka Mitsui et al.
Thyroid transcription factor-1 (TTF-1) is expressed in the thyroid gland, lungs, and brain, and has also been reported in thymomas. While some studies have suggested TTF-1 as a specific marker for type AB thymoma, others have noted signific...
A novel 9-gene classifier for predicting distant metastasis of soft-tissue sarcoma and multiple malignancies [0.03%]
一种新的九基因分类器用于预测软组织肉瘤和其他多种恶性肿瘤的远处转移
Atsushi Tanabe,Jerry Ndzinu,Hiroeki Sahara
Atsushi Tanabe
Distant metastasis of soft tissue sarcoma (STS) is a risk factor with a significant impact on patient prognosis. Therefore, accurate prediction of STS metastatic risk is important in the therapeutic management of STS patients. In this study...
Epidemiology and treatments of neuroendocrine prostate cancer in a large commercially insured population in the US [0.03%]
美国大型商业保险人群神经内分泌前列腺癌的流行病学和治疗状况
Zdravko Vassilev,Qayyim Said,Jihong Zong et al.
Zdravko Vassilev et al.
Background: Neuroendocrine prostate cancer (NEPC) is a highly aggressive prostate cancer (PCa) subtype diagnosed de novo or arising from neuroendocrine differentiation of adenocarcinoma following androgen deprivation ther...
Uncovering the transcriptomic basis of endoxifen resistance in ER+ breast cancer cells: Insights from bioinformatics analysis [0.03%]
基于生物信息学分析的雌激素受体阳性乳腺癌细胞中恩杂曲滨耐药性的转录组研究基础
H Lawrence Remmel,Sandra S Hammer,John R Hawse et al.
H Lawrence Remmel et al.
Estrogen receptor alpha-positive (ER+) breast cancer remains a major clinical challenge due to the development of de novo and acquired resistance to endocrine therapy. (Z)-endoxifen (hereafter endoxifen), the most abundant active tamoxifen ...
Artificial intelligence in Glioblastoma Diagnostics: Integrating MRI, histopathology, and molecular profiling [0.03%]
基于MRI、组织病理学和分子分型的胶质母细胞瘤诊断的人工智能研究
Ghasem Ahangari,Hamid Norioun,Shadi Ghaemi et al.
Ghasem Ahangari et al.
Background and objective: Gliomas are among the most aggressive and diagnostically challenging brain tumors. Conventional pathways (MRI, histopathology, clinical assessment) have limited sensitivity for early or low-grade...