Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites [0.03%]
Burkholderia 感染细菌的关键抗菌代谢产物的发现、作用机制和分泌方式
Yoana D Petrova,Eshwar Mahenthiralingam
Yoana D Petrova
Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, includi...
The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis [0.03%]
甘油三酯的功能及DGAT1抑制剂用于治疗结核分枝杆菌的再利用作用
Alice R Moorey,Gurdyal S Besra
Alice R Moorey
Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which ...
Biochemical characterization of Pectin Methylesterase Inhibitor 3 from Arabidopsis thaliana [0.03%]
来源于阿拉伯芥的pectin甲酯酶抑制因子PMEI3的生物化学性质研究
Fan Xu,Martine Gonneau,Elvina Faucher et al.
Fan Xu et al.
The de-methylesterification of the pectic polysaccharide homogalacturonan (HG) by pectin methylesterases (PMEs) is a critical step in the control of plant cell expansion and morphogenesis. Plants have large gene families encoding PMEs but a...
Phosphocholine decoration of Proteus mirabilis O18 LPS induces hydrophobicity of the cell surface and electrokinetic potential, but does not alter the adhesion to solid surfaces [0.03%]
磷脂胆碱修饰的 Proteus mirabilis O18 脂多糖诱导细胞表面疏水性和电动力学特性改变，但不降低对固体表面的粘附性
Grzegorz Czerwonka,Katarzyna Durlik-Popińska,Marcin Drabik et al.
Grzegorz Czerwonka et al.
Proteus mirabilis harbours a variety of O antigens, permitting evasion of the host immune response. LPS decoration with phosphocholine increases cell surface hydrophobicity and decreases electrokinetic potential, which may interfere with an...
Nitisha Gurav,Olivia J S Macleod,Paula MacGregor et al.
Nitisha Gurav et al.
East Coast Fever is a devastating African cattle disease caused by the apicomplexan parasite, Theileria parva. Little is known about the cell surface, and few proteins have been identified. Here, we take an in silico approach to identify no...
A review on pilus assembly mechanisms in Gram-positive and Gram-negative bacteria [0.03%]
革兰氏阳性菌和革兰氏阴性菌菌毛装配机制的研究进展
Tamilarasi Shanmugasundarasamy,Deenadayalan Karaiyagowder Govindarajan,Kumaravel Kandaswamy
Tamilarasi Shanmugasundarasamy
The surface of Gram-positive and Gram-negative bacteria contains long hair-like proteinaceous protrusion known as pili or fimbriae. Historically, pilin proteins were considered to play a major role in the transfer of genetic material during...
Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor [0.03%]
耐氟康唑的耳霉菌临床分离株细胞壁几丁质水平升高，并且更易受到葡萄糖胺-6-磷酸合酶抑制剂的影响
Garima Shahi,Mohit Kumar,Andrzej S Skwarecki et al.
Garima Shahi et al.
In 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is ...
Virulence factors of uropathogens and their role in host pathogen interactions [0.03%]
尿路病原菌的致病毒素及在宿主-病原菌相互作用中的作用
Deenadayalan Karaiyagowder Govindarajan,Kumaravel Kandaswamy
Deenadayalan Karaiyagowder Govindarajan
Gram-positive and Gram-negative bacterial pathogens are commonly found in Urinary Tract Infection (UTI), particularly infected in females like pregnant women, elder people, sexually active, or individuals prone to other risk factors for UTI...
Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus [0.03%]
表面活性蛋白D抑制烟曲霉生长、改变其细胞表面多糖暴露和免疫激活潜能
Sarah Sze Wah Wong,Sarah Dellière,Natalia Schiefermeier-Mach et al.
Sarah Sze Wah Wong et al.
Humoral immunity plays a defensive role against invading microbes. However, it has been largely overlooked with respect to Aspergillus fumigatus, an airborne fungal pathogen. Previously, we have demonstrated that surfactant protein D (SP-D)...
Rebecca A Hall,Edward W J Wallace
Rebecca A Hall
Pathogenic fungi hide from their hosts by camouflage, obscuring immunogenic cell wall components such as beta-glucan with innocuous coverings such as mannoproteins and alpha-glucan that are less readily recognised by the host. Attempts to u...