Arturo Casadevall,Neil A R Gow
Arturo Casadevall
•The outer surfaces of fungi and bacteria are highly dynamic, flexible, regulated and adaptable structures.•The term "cell wall" is conceptually limiting and insufficient to adequately describe the outer surface of bacteria and fungi.•Th...
Enhanced immunogenicity of Mycobacterium bovis BCG through CRISPRi mediated depletion of AftC [0.03%]
通过CRISPRi介导的AftC耗尽来提高牛分枝杆菌BCG的免疫原性
Bala T S A Madduri,Lauren Allen,Stephen C Taylor et al.
Bala T S A Madduri et al.
Mycobacterium tuberculosis causes the disease tuberculosis and affects a third of the world's population. The recent COVID-19 pandemic exacerbated the situation with a projected 27% increase in tuberculosis related deaths. M. tuberculosis h...
Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes [0.03%]
肽聚糖生物合成失衡会改变单核细胞增生李斯特菌的细胞表面电荷
Lisa Maria Schulz,Patricia Rothe,Sven Halbedel et al.
Lisa Maria Schulz et al.
The bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and wall teichoic aci...
Outer membrane-anchoring enables LpoB to regulate peptidoglycan synthesis rate [0.03%]
外膜锚定使LpoB能够调节肽聚糖合成速率
Ali A Kermani,Jacob Biboy,Daniela Vollmer et al.
Ali A Kermani et al.
Peptidoglycan (PG) is an essential component of the cell envelope in most bacteria, responsible for maintaining the shape of the cell and protecting the cell from environmental stresses. The growth of the PG layer during cell elongation and...
Impact of changes at the Candida albicans cell surface upon immunogenicity and colonisation in the gastrointestinal tract [0.03%]
白念珠菌细胞表面变化对其免疫原性和肠道定植的影响
Gabriela M Avelar,Ivy M Dambuza,Liviana Ricci et al.
Gabriela M Avelar et al.
The immunogenicity of Candida albicans cells is influenced by changes in the exposure of microbe-associated molecular patterns (MAMPs) on the fungal cell surface. Previously, the degree of exposure on the C. albicans cell surface of the imm...
The nature of the fungal cargo induces significantly different temporal programmes of macrophage phagocytosis [0.03%]
真菌货物的性质可显著改变巨噬细胞吞咽作用的时序程序
María Fernanda Alonso,Judith M Bain,Fiona M Rudkin et al.
María Fernanda Alonso et al.
Phagocytosis is an essential component of our immune defence against fungal pathogens. Differences in the dynamics of phagocyte migration, recognition, uptake and phagolysosome maturation are dependent on the characteristics of the fungal c...
Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites [0.03%]
Burkholderia 感染细菌的关键抗菌代谢产物的发现、作用机制和分泌方式
Yoana D Petrova,Eshwar Mahenthiralingam
Yoana D Petrova
Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, includi...
The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis [0.03%]
甘油三酯的功能及DGAT1抑制剂用于治疗结核分枝杆菌的再利用作用
Alice R Moorey,Gurdyal S Besra
Alice R Moorey
Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which ...
Biochemical characterization of Pectin Methylesterase Inhibitor 3 from Arabidopsis thaliana [0.03%]
来源于阿拉伯芥的pectin甲酯酶抑制因子PMEI3的生物化学性质研究
Fan Xu,Martine Gonneau,Elvina Faucher et al.
Fan Xu et al.
The de-methylesterification of the pectic polysaccharide homogalacturonan (HG) by pectin methylesterases (PMEs) is a critical step in the control of plant cell expansion and morphogenesis. Plants have large gene families encoding PMEs but a...
Phosphocholine decoration of Proteus mirabilis O18 LPS induces hydrophobicity of the cell surface and electrokinetic potential, but does not alter the adhesion to solid surfaces [0.03%]
磷脂胆碱修饰的 Proteus mirabilis O18 脂多糖诱导细胞表面疏水性和电动力学特性改变，但不降低对固体表面的粘附性
Grzegorz Czerwonka,Katarzyna Durlik-Popińska,Marcin Drabik et al.
Grzegorz Czerwonka et al.
Proteus mirabilis harbours a variety of O antigens, permitting evasion of the host immune response. LPS decoration with phosphocholine increases cell surface hydrophobicity and decreases electrokinetic potential, which may interfere with an...