Micro-compression analysis of biopolymer-producing bacteria using Cupriavidus necator as the model bacterium [0.03%]
用Cupriavidus necator 作为模式菌的生物聚合体产生细菌微压缩分析
Marketa Khyrova,Josef Sepitka,Vojtech Cerny et al.
Marketa Khyrova et al.
With the development of highly sensitive experimental techniques, the mechanical properties of bacterial cells have become an important research topic. However, existing models used to fit experimental data from micro-compression tests ofte...
Compromising UPD-sugar nucleotide biosynthesis attenuates Candida albicans viability, virulence and drug sensitivity [0.03%]
削弱假皮酵母糖核苷酸生物合成可减弱其存活率、毒力和药物敏感性
Dhara Malavia-Jones,Ian Leaves,Jemima Onime et al.
Dhara Malavia-Jones et al.
Candida albicans is an opportunistic fungal pathogen that can cause a variety of superficial and life-threatening systemic infections. Relatively few clinically effective antifungal therapies are available, and the increasing prevalence of ...
Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against Aspergillus fumigatus [0.03%]
Rho2介导的细胞壁重塑可增强manogepix对烟曲霉的抗真菌作用
Sean Brazil,Isabel Kopp-Fouquet,Samuel Zen Kai Yap et al.
Sean Brazil et al.
Fosmanogepix is a new antifungal agent currently undergoing phase 3 clinical trials. Its active moiety, manogepix, inhibits Gwt1 which is an enzyme essential for the assembly and attachment of glycosylphosphatidylinositol anchors to cell wa...
Emerging evidence for a multitude of mechanisms and factors that determine amphotericin B resistance in pathogenic fungi [0.03%]
越来越多的证据表明决定病原真菌曲安奈星耐药性的机制和因素多种多样
Anshu Chauhan,Neil A R Gow,Rajendra Prasad
Anshu Chauhan
The fungicidal polyene amphotericin B (AMB) is the oldest antifungal for the treatment of systemic infections, and it remains a critical broad-spectrum therapeutic option, despite its well-documented nephrotoxicity. In many countries use of...
Functions of the cell wall polysaccharide schizophyllan during vegetative growth of Schizophyllum commune [0.03%]
Schizophyllum commune 菌丝生长过程中细胞壁多糖schizophyllan的功能研究
Fleur E L Kleijburg,Ella M Schunselaar,Adil A Safeer et al.
Fleur E L Kleijburg et al.
Schizophyllan, a β-(1,3)(1,6)-glucan, is part of the cell wall of the mushroom-forming fungus Schizophyllum commune and is also released into the culture medium. It has various commercial applications but the natural function of schizophyl...
Pap1 is an adhesin involved in the interaction of Sporothrix schenckii and Sporothrix brasiliensis with the host [0.03%]
Pap1是Sporothrix schenckii和Sporothrix brasiliensis与宿主相互作用的黏附素
Leonardo Padró-Villegas,Julieta I Aguilera-Domínguez,Luz A López-Ramírez et al.
Leonardo Padró-Villegas et al.
Sporothrix schenckii and Sporothrix brasiliensis are causative agents of sporotrichosis, a mycosis that affects humans and other mammals. Adhesins are considered among the primary virulence factors of these species; however, their molecular...
Salmonella encodes murein lipoproteins differing in the anchoring to peptidoglycan and intermolecular association [0.03%]
沙门氏菌编码与肽聚糖锚定和分子间关联不同的MurJ蛋白
Marcos Peñalver,Juan J Cestero,Alberto Paradela et al.
Marcos Peñalver et al.
Murein lipoprotein (Lpp), also known as Braun's lipoprotein, stabilizes the cell wall of Escherichia coli by covalently tethering the outer membrane to the peptidoglycan (PG). Unlike E. coli, Salmonella enterica serovar Typhimurium encodes ...
Host TGF-β signalling facilitates Vi-capsule mediated adaptive immune evasion and vertical transmission of Salmonella Typhi in Caenorhabditis elegans [0.03%]
霍乱弧菌囊泡通过TGF-β信号促进适应性免疫逃避和沙门氏菌在秀丽隐杆线虫中的垂直传播
Bynedi Seshadhri Chinna Mounish,Ravichandran Monisha,Krishnaswamy Balamurugan
Bynedi Seshadhri Chinna Mounish
Bacterial infections trigger robust host immune responses, while pathogens concurrently adapt to enhance survival within the host. In our previous study, we observed 24 h of Salmonella Typhi infection in Caenorhabditis elegans colonized the...
Relating corynebacterial cell envelope layers to its biochemical and physical properties [0.03%]
结核分枝杆菌细胞Envelope各层结构与其生化和物理性质之间的关系研究
Mamata Modak,Uchenna Watson Waturuocha,Deepak Kumar Saini et al.
Mamata Modak et al.
The cell wall plays a central role in maintaining bacterial shape and structural stability. In the Corynebacteriaceae family, which includes Corynebacterium, Mycobacterium, Nocardia, and Rhodococcus, the envelope has a distinctive organizat...
Surface-dependent reorganization of Chlorella vulgaris cell wall components revealed by AFM and SRS microscopy [0.03%]
基于AFM和SRS显微镜的细胞壁成分的表面依赖性重组研究
Adriana Pereira C Sánchez,Cécile Pouzet,Audrey Beaussart et al.
Adriana Pereira C Sánchez et al.
Characterization of microalgae cell wall properties using Atomic Force Microscopy (AFM) depends critically on the immobilization strategy employed. In this study, we investigated how various immobilization surfaces influence the biophysical...