Nitisha Gurav,Olivia J S Macleod,Paula MacGregor et al.
Nitisha Gurav et al.
East Coast Fever is a devastating African cattle disease caused by the apicomplexan parasite, Theileria parva. Little is known about the cell surface, and few proteins have been identified. Here, we take an in silico approach to identify no...
A review on pilus assembly mechanisms in Gram-positive and Gram-negative bacteria [0.03%]
革兰氏阳性菌和革兰氏阴性菌菌毛装配机制的研究进展
Tamilarasi Shanmugasundarasamy,Deenadayalan Karaiyagowder Govindarajan,Kumaravel Kandaswamy
Tamilarasi Shanmugasundarasamy
The surface of Gram-positive and Gram-negative bacteria contains long hair-like proteinaceous protrusion known as pili or fimbriae. Historically, pilin proteins were considered to play a major role in the transfer of genetic material during...
Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor [0.03%]
耐氟康唑的耳霉菌临床分离株细胞壁几丁质水平升高，并且更易受到葡萄糖胺-6-磷酸合酶抑制剂的影响
Garima Shahi,Mohit Kumar,Andrzej S Skwarecki et al.
Garima Shahi et al.
In 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is ...
Virulence factors of uropathogens and their role in host pathogen interactions [0.03%]
尿路病原菌的致病毒素及在宿主-病原菌相互作用中的作用
Deenadayalan Karaiyagowder Govindarajan,Kumaravel Kandaswamy
Deenadayalan Karaiyagowder Govindarajan
Gram-positive and Gram-negative bacterial pathogens are commonly found in Urinary Tract Infection (UTI), particularly infected in females like pregnant women, elder people, sexually active, or individuals prone to other risk factors for UTI...
Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus [0.03%]
表面活性蛋白D抑制烟曲霉生长、改变其细胞表面多糖暴露和免疫激活潜能
Sarah Sze Wah Wong,Sarah Dellière,Natalia Schiefermeier-Mach et al.
Sarah Sze Wah Wong et al.
Humoral immunity plays a defensive role against invading microbes. However, it has been largely overlooked with respect to Aspergillus fumigatus, an airborne fungal pathogen. Previously, we have demonstrated that surfactant protein D (SP-D)...
Rebecca A Hall,Edward W J Wallace
Rebecca A Hall
Pathogenic fungi hide from their hosts by camouflage, obscuring immunogenic cell wall components such as beta-glucan with innocuous coverings such as mannoproteins and alpha-glucan that are less readily recognised by the host. Attempts to u...
Characterization of Neurospora crassa GH16, GH17, and GH72 gene families of cell wall crosslinking enzymes [0.03%]
棒曲霉GH16、GH17和GH72族细胞壁交联酶的特征分析
Pavan Patel,Stephen J Free
Pavan Patel
GH16 chitin transferases, GH17 β-1,3-glucan transferases, and GH72 β-1,3-glucan/lichenin transferases are important fungal cell wall crosslinking enzymes. The Neurospora crassa genome encodes three genes from the GH17 gene family and five...
Molecular sensors reveal the mechano-chemical response of Phytophthora infestans walls and membranes to mechanical and chemical stress [0.03%]
分子传感器揭示了Phytophthora infestans细胞壁和膜对机械和化学刺激的机理化学响应
Lucile Michels,Jochem Bronkhorst,Michiel Kasteel et al.
Lucile Michels et al.
Phytophthora infestans, causal agent of late blight in potato and tomato, remains challenging to control. Unravelling its biomechanics of host invasion, and its response to mechanical and chemical stress, could provide new handles to combat...
Polygalacturonase activity promotes aberrant cell separation in the quasimodo2 mutant of Arabidopsis thaliana [0.03%]
聚半乳糖醛酸酶活性促进拟南芥突变体quasimodo2中异常细胞分离现象的发展
William J Barnes,Ellen Zelinsky,Charles T Anderson
William J Barnes
In plants, cell adhesion relies on balancing the integrity of the pectin-rich middle lamella with wall loosening during tissue expansion. Mutation of QUASIMODO2 (QUA2), a pectin methyltransferase, causes defective hypocotyl elongation and c...
The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation [0.03%]
MmpL3抑制剂的多靶点特性：BM212系列化合物与EthR2结合，EthR2是乙硫胺激活的转录调节因子
Alice R Moorey,Alejandro Cabanillas,Sarah M Batt et al.
Alice R Moorey et al.
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) ensures that drug discovery efforts remain at the forefront of TB research. There are multiple different experimental approaches that can be employed in the discove...