Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against Aspergillus fumigatus [0.03%]
Rho2介导的细胞壁重塑可增强manogepix对烟曲霉的抗真菌作用
Sean Brazil,Isabel Kopp-Fouquet,Samuel Zen Kai Yap et al.
Sean Brazil et al.
Fosmanogepix is a new antifungal agent currently undergoing phase 3 clinical trials. Its active moiety, manogepix, inhibits Gwt1 which is an enzyme essential for the assembly and attachment of glycosylphosphatidylinositol anchors to cell wa...
Emerging evidence for a multitude of mechanisms and factors that determine amphotericin B resistance in pathogenic fungi [0.03%]
越来越多的证据表明决定病原真菌曲安奈星耐药性的机制和因素多种多样
Anshu Chauhan,Neil A R Gow,Rajendra Prasad
Anshu Chauhan
The fungicidal polyene amphotericin B (AMB) is the oldest antifungal for the treatment of systemic infections, and it remains a critical broad-spectrum therapeutic option, despite its well-documented nephrotoxicity. In many countries use of...
Functions of the cell wall polysaccharide schizophyllan during vegetative growth of Schizophyllum commune [0.03%]
Schizophyllum commune 菌丝生长过程中细胞壁多糖schizophyllan的功能研究
Fleur E L Kleijburg,Ella M Schunselaar,Adil A Safeer et al.
Fleur E L Kleijburg et al.
Schizophyllan, a β-(1,3)(1,6)-glucan, is part of the cell wall of the mushroom-forming fungus Schizophyllum commune and is also released into the culture medium. It has various commercial applications but the natural function of schizophyl...
Pap1 is an adhesin involved in the interaction of Sporothrix schenckii and Sporothrix brasiliensis with the host [0.03%]
Pap1是Sporothrix schenckii和Sporothrix brasiliensis与宿主相互作用的黏附素
Leonardo Padró-Villegas,Julieta I Aguilera-Domínguez,Luz A López-Ramírez et al.
Leonardo Padró-Villegas et al.
Sporothrix schenckii and Sporothrix brasiliensis are causative agents of sporotrichosis, a mycosis that affects humans and other mammals. Adhesins are considered among the primary virulence factors of these species; however, their molecular...
Salmonella encodes murein lipoproteins differing in the anchoring to peptidoglycan and intermolecular association [0.03%]
沙门氏菌编码与肽聚糖锚定和分子间关联不同的MurJ蛋白
Marcos Peñalver,Juan J Cestero,Alberto Paradela et al.
Marcos Peñalver et al.
Murein lipoprotein (Lpp), also known as Braun's lipoprotein, stabilizes the cell wall of Escherichia coli by covalently tethering the outer membrane to the peptidoglycan (PG). Unlike E. coli, Salmonella enterica serovar Typhimurium encodes ...
Host TGF-β signalling facilitates Vi-capsule mediated adaptive immune evasion and vertical transmission of Salmonella Typhi in Caenorhabditis elegans [0.03%]
霍乱弧菌囊泡通过TGF-β信号促进适应性免疫逃避和沙门氏菌在秀丽隐杆线虫中的垂直传播
Bynedi Seshadhri Chinna Mounish,Ravichandran Monisha,Krishnaswamy Balamurugan
Bynedi Seshadhri Chinna Mounish
Bacterial infections trigger robust host immune responses, while pathogens concurrently adapt to enhance survival within the host. In our previous study, we observed 24 h of Salmonella Typhi infection in Caenorhabditis elegans colonized the...
Relating corynebacterial cell envelope layers to its biochemical and physical properties [0.03%]
结核分枝杆菌细胞Envelope各层结构与其生化和物理性质之间的关系研究
Mamata Modak,Uchenna Watson Waturuocha,Deepak Kumar Saini et al.
Mamata Modak et al.
The cell wall plays a central role in maintaining bacterial shape and structural stability. In the Corynebacteriaceae family, which includes Corynebacterium, Mycobacterium, Nocardia, and Rhodococcus, the envelope has a distinctive organizat...
Surface-dependent reorganization of Chlorella vulgaris cell wall components revealed by AFM and SRS microscopy [0.03%]
基于AFM和SRS显微镜的细胞壁成分的表面依赖性重组研究
Adriana Pereira C Sánchez,Cécile Pouzet,Audrey Beaussart et al.
Adriana Pereira C Sánchez et al.
Characterization of microalgae cell wall properties using Atomic Force Microscopy (AFM) depends critically on the immobilization strategy employed. In this study, we investigated how various immobilization surfaces influence the biophysical...
An anti-adhesive peptide found in extracellular vesicles from Sporothrix brasiliensis and Sporothrix schenckii [0.03%]
从巴西副球孢子菌和申克氏副球孢子菌中发现的细胞外囊泡中的抗粘附肽
Cássia M de Souza,Nicolly A Sensato,Flavia C G Reis et al.
Cássia M de Souza et al.
Sporothrix brasiliensis and Sporothrix schenckii are major causative agents of sporotrichosis, a neglected fungal disease with growing public health relevance. These pathogens release extracellular vesicles (EVs) that contribute to host-pat...
Revealing structure and shaping priorities in plant and fungal cell wall architecture via solid-state NMR [0.03%]
通过固态NMR揭示和塑造植物及真菌细胞壁结构及其重点优先项
Peng Xiao,Priya Sahu,Sarah A Pfaff et al.
Peng Xiao et al.
Plant and fungal cell walls are essential for growth, adaptation, and survival, with their intricate architectures dictating both resistance to stress and susceptibility to antifungal or biomass-degrading strategies. Understanding how these...