Acetylation and accessibility of Cryptococcus neoformans cell wall chitosans influence the strength of host immune responses [0.03%]
细胞壁壳聚糖的乙酰化和可及性会影响新型隐球菌诱发的宿主免疫反应强度
Margareta J Hellmann,Rajendra Upadhya,Evelyn Tchoub et al.
Margareta J Hellmann et al.
The fungal pathogen Cryptococcus neoformans causes fatal cryptococcal meningitis, a significant global health risk. Unlike most fungi, C. neoformans expresses chitin deacetylases that convert its cell wall chitin into chitosan, helping to e...
Plasma membrane transporters Alp1 and Nrt1 mediate the uptake of benzamidine conjugates in fungi [0.03%]
苯胺idine衍生物通过白念珠菌 plasma membrane transporter ALP1 和NRT1摄取
Xueyang Jin,Yunfan Yang,Xue Wang et al.
Xueyang Jin et al.
Efflux pumps confer antifungal resistance. Benzamidine (BM) conjugates overcome resistance by enhancing intracellular accumulation, but their cellular uptake mechanism remains unclear. A screen of membrane transport protein mutants revealed...
Ricin B lectin-like proteins mediate thermotolerance, cell wall integrity, and fungal virulence in Cryptococcus neoformans [0.03%]
里西诺夫素B凝集素类似蛋白介导新型隐球菌的热应激耐受性、细胞壁完整性及真菌致病力
Xiaoji Shu,Xitong Zhang,Yujia Zhao et al.
Xiaoji Shu et al.
Cryptococcus neoformans is an important human fungal pathogen. Cell surface proteins mediate Cryptococcus-host interactions and play critical roles in fungal virulence. Proteins containing ricin B lectin-like domains (RBD) are involved in p...
Neurospora crassa Δ ccg-8 compromises cell surface integrity and antifungal tolerance: Insights from in vitro and Galleria mellonella studies [0.03%]
模式真菌 Neurospora crassa Δ ccg-8 缺陷型敲除株表皮完整性与抗真菌敏感性受损：基于体外及家蚕模型的机制研究
Ján Víglaš,Katarína Víglaš,Pavol Farkaš et al.
Ján Víglaš et al.
A comprehensive reference organism is often lacking when studying the adaptation of filamentous fungi to environmental stressors. This work investigates the mechanism underlying the response of N. crassa to stress conditions by focusing on ...
Micro-compression analysis of biopolymer-producing bacteria using Cupriavidus necator as the model bacterium [0.03%]
用Cupriavidus necator 作为模式菌的生物聚合体产生细菌微压缩分析
Marketa Khyrova,Josef Sepitka,Vojtech Cerny et al.
Marketa Khyrova et al.
With the development of highly sensitive experimental techniques, the mechanical properties of bacterial cells have become an important research topic. However, existing models used to fit experimental data from micro-compression tests ofte...
Compromising UPD-sugar nucleotide biosynthesis attenuates Candida albicans viability, virulence and drug sensitivity [0.03%]
削弱假皮酵母糖核苷酸生物合成可减弱其存活率、毒力和药物敏感性
Dhara Malavia-Jones,Ian Leaves,Jemima Onime et al.
Dhara Malavia-Jones et al.
Candida albicans is an opportunistic fungal pathogen that can cause a variety of superficial and life-threatening systemic infections. Relatively few clinically effective antifungal therapies are available, and the increasing prevalence of ...
Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against Aspergillus fumigatus [0.03%]
Rho2介导的细胞壁重塑可增强manogepix对烟曲霉的抗真菌作用
Sean Brazil,Isabel Kopp-Fouquet,Samuel Zen Kai Yap et al.
Sean Brazil et al.
Fosmanogepix is a new antifungal agent currently undergoing phase 3 clinical trials. Its active moiety, manogepix, inhibits Gwt1 which is an enzyme essential for the assembly and attachment of glycosylphosphatidylinositol anchors to cell wa...
Emerging evidence for a multitude of mechanisms and factors that determine amphotericin B resistance in pathogenic fungi [0.03%]
越来越多的证据表明决定病原真菌曲安奈星耐药性的机制和因素多种多样
Anshu Chauhan,Neil A R Gow,Rajendra Prasad
Anshu Chauhan
The fungicidal polyene amphotericin B (AMB) is the oldest antifungal for the treatment of systemic infections, and it remains a critical broad-spectrum therapeutic option, despite its well-documented nephrotoxicity. In many countries use of...
Functions of the cell wall polysaccharide schizophyllan during vegetative growth of Schizophyllum commune [0.03%]
Schizophyllum commune 菌丝生长过程中细胞壁多糖schizophyllan的功能研究
Fleur E L Kleijburg,Ella M Schunselaar,Adil A Safeer et al.
Fleur E L Kleijburg et al.
Schizophyllan, a β-(1,3)(1,6)-glucan, is part of the cell wall of the mushroom-forming fungus Schizophyllum commune and is also released into the culture medium. It has various commercial applications but the natural function of schizophyl...
Pap1 is an adhesin involved in the interaction of Sporothrix schenckii and Sporothrix brasiliensis with the host [0.03%]
Pap1是Sporothrix schenckii和Sporothrix brasiliensis与宿主相互作用的黏附素
Leonardo Padró-Villegas,Julieta I Aguilera-Domínguez,Luz A López-Ramírez et al.
Leonardo Padró-Villegas et al.
Sporothrix schenckii and Sporothrix brasiliensis are causative agents of sporotrichosis, a mycosis that affects humans and other mammals. Adhesins are considered among the primary virulence factors of these species; however, their molecular...