Cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain long-term drug-free remission in paediatric Crohn's disease (CD-HOPE): an open-label, endpoint-blinded, randomised controlled trial [0.03%]
儿童克罗恩病(CD-HOPE)的长期无药物缓解维持：周期性全肠内营养与部分肠内营养的对照研究
Bénédicte Pigneur,Christine Martinez-Vinson,Aurélie Bourmaud et al.
Bénédicte Pigneur et al.
Background: For children with Crohn's disease, there is a marked demand for long-term nutritional treatment strategies to avoid the side-effects related to drug treatment. We aimed to investigate whether paediatric patien...
ALG-000184 (pevifoscorvir sodium) monotherapy in participants with chronic HBV infection: a phase 1, multicentre, randomised, dose escalation trial [0.03%]
一项评估ALG-000184（pevifiprant钠）单药治疗慢性HBV感染受试者的I期、多中心、随机、剂量递增试验
Man-Fung Yuen,Kosh Agarwal,Alina Jucov et al.
Man-Fung Yuen et al.
Background: ALG-000184 (pevifoscorvir sodium) is a prodrug of the class-E (empty) capsid assembly modulator (CAM), ALG-001075. CAM-Es prevent hepatitis B virus (HBV) replication by inhibiting capsid assembly and pregenomi...
Mechanisms and pathophysiology leading to development of small intestinal microbial dysbiosis [0.03%]
导致小肠微生物菌群失调的发生机制及病理生理学
John A Damianos,Xiao Jing Wang,Michael Camilleri
John A Damianos
Small intestinal microbial dysbiosis (SIMD) describes clinical syndromes attributed to overabundance of microbes within the small intestine. Usually attributed to bacteria (but also less commonly to archaea and fungi), SIMD arises as a seco...
Efficacy and safety of subcutaneous guselkumab induction therapy in participants with moderately to severely active ulcerative colitis (ASTRO): a double-blind, treat-through, randomised, placebo-controlled, phase 3 trial [0.03%]
克唑替尼治疗ROS1阳性晚期非小细胞肺癌患者的疗效和安全性：一项开放性、多中心的II期研究
Millie Long,Jessica R Allegretti,Silvio Danese et al.
Millie Long et al.
Background: Approved IL-23p19 subunit inhibitors, including guselkumab, require intravenous induction dosing in patients with ulcerative colitis. We aimed to evaluate the efficacy and safety of subcutaneous guselkumab ind...
Chronic liver disease and hepatology care in transgender and gender diverse populations [0.03%]
慢性肝病与性别多样人群的肝脏护理
Thanh N Nguyen,Whitney E Jackson,Nitzan C Roth et al.
Thanh N Nguyen et al.
Transgender and gender diverse (trans) people experience unique minority stressors related to their gender identity, along with additional psychosocial and systemic stressors that contribute to health disparities. Many risk factors for chro...
Samantha Conley,Kendra J Kamp,Sunanda V Kane
Samantha Conley
Definitions, diagnosis, management, and outcomes of upper gastrointestinal Crohn's disease: an international, expert RAND/UCLA appropriateness study [0.03%]
关于克罗恩病的定义、诊断、治疗和结局的国际专家RAND/UCLA适宜性研究
Nathaniel A Cohen,Dominik Bettenworth,Neta Sror et al.
Nathaniel A Cohen et al.
Patients with Crohn's disease can have isolated or co-existent upper gastrointestinal involvement, but this is an understudied clinical manifestation. There are neither standardised definitions nor diagnostic or management recommendations t...
Alexandra Damasio Todescatto,Paulo Gustavo Kotze
Alexandra Damasio Todescatto
Appendicectomy versus switching to a JAK inhibitor in inducing remission in patients with active ulcerative colitis after biologic therapy failure (COSTA): 1-year results of a multicentre, prospective, cohort study [0.03%]
在生物制剂治疗失败的活动性溃疡性结肠炎患者中，回切术与换用JAK抑制剂诱导缓解的比较（COSTA）：多中心前瞻性队列研究的一年结果
Eva Visser,Maud A Reijntjes,Lianne Heuthorst et al.
Eva Visser et al.
Background: Although retrospective and limited prospective observational studies have suggested a potential benefit of appendicectomy in therapy-refractory ulcerative colitis, its effectiveness compared with advanced medi...