Adjuvant chemoradiotherapy versus completion total mesorectal excision after local excision for early rectal cancer (TESAR): a multicentre, randomised, controlled, phase 3, non-inferiority trial [0.03%]
经局部切除后早期直肠癌患者接受术后放化疗与根治性全系膜切除手术的疗效比较（TESAR研究）：一项多中心、随机对照的Ⅲ期非劣效临床试验
Laura R Moolenaar,Mahsoem Ali,Theo J Aufenacker et al.
Laura R Moolenaar et al.
Background: Completion total mesorectal excision (cTME) after local excision of early rectal cancer is associated with substantial morbidity and impaired functional outcomes. This study aimed to assess the oncological out...
The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729-001): a phase 1a/b trial [0.03%]
新型小干扰RNA药物imidusiran单剂量和多剂量在健康人群及慢性乙型肝炎患者中的I期临床研究（AB-729-001）
Man-Fung Yuen,Edward Gane,Jacinta A Holmes et al.
Man-Fung Yuen et al.
Background: Functional cure of chronic hepatitis B requires a sustained loss of HBsAg and hepatitis B virus (HBV) DNA, which is unlikely with current therapies. We aimed to investigate the safety, antiviral activity, and ...
Intestinal ultrasound to detect postoperative recurrence in patients with Crohn's disease: an international, multidisciplinary, RAND/UCLA appropriateness method study [0.03%]
克罗恩病术后复发的肠道超声检查：国际多学科RAND/UCLA适宜性研究
Christopher Ma,Siwar Albashir,Mariangela Allocca et al.
Christopher Ma et al.
Background: Intestinal ultrasound is a non-invasive method increasingly used to diagnose and monitor disease activity in patients with inflammatory bowel disease; however, there is no consensus on the appropriate implemen...
Management of colorectal cancer in older adults: an expert panel recommendation to guide daily clinical practice [0.03%]
老年患者的结直肠癌管理：指导日常临床实践的专家小组推荐意见
Gabor Liposits,Thierry André,Thomas Aparicio et al.
Gabor Liposits et al.
Colorectal cancer predominantly affects older adults (ie, those aged 70 years or older). Along with shifting demographic trends, the number of patients with colorectal cancer in this age group is estimated to sharply increase globally over ...
Breaking the therapeutic ceiling in inflammatory bowel disease: myth or reality? [0.03%]
突破炎症性肠病治疗的瓶颈：神话还是现实？
Virginia Solitano,Vipul Jairath,Fernando Magro et al.
Virginia Solitano et al.
Despite an expanding therapeutic armamentarium, remission rates in inflammatory bowel disease (IBD) appear to plateau at 30-50% after 1 year of treatment, leading to the concept of a therapeutic ceiling with single agents. This Viewpoint ch...
Infected for Science [0.03%]
被科学毁容
Talha Burki
Talha Burki
Ahmed Bayoumy,Nanne de Boer
Ahmed Bayoumy
Appendicectomy: a disease-modifying treatment for ulcerative colitis? - Authors' reply [0.03%]
阑尾切除术可改变溃疡性结肠炎病程吗？——作者答复
Eva Visser,Christianne J Buskens
Eva Visser
Michael Colwill,Richard Pollok,Sailish Honap et al.
Michael Colwill et al.