MicroRNA-29a-5p attenuates hemorrhagic transformation and improves outcomes after mechanical reperfusion for acute ischemic stroke [0.03%]
microRNA-29a-5p可减轻机械性再灌注急性缺血性卒中的出血转化并改善预后
Chang-Luo Li,Jin-Kun Zhuang,Zhong Liu et al.
Chang-Luo Li et al.
Background: Hemorrhage transformation (HT) following endovascular reperfusion treatment is associated with worse clinical outcomes in acute ischemic stroke patients. MicroRNA (miR) modulates several aspects of cerebral is...
USF1-activated hsa_circ_0076691 induces oxaliplatin resistance via facilitating FGF9 expression in miR-589-3p-dependent manners [0.03%]
USF1激活的hsa_circ_0076691通过miR-589-3p依赖方式促进FGF9表达从而诱导奥沙利铂耐药性
Lingyu Tang,Xuan Deng,Ming Guan et al.
Lingyu Tang et al.
Chemotherapeutic efficacy in colorectal cancer (CRC) is significantly hindered by the development of drug resistance. Emerging evidence indicates that circular RNAs (circRNAs) play pivotal roles in various cancer-related biological processe...
LncPTEN1, a long non-coding RNA generated from PTEN, suppresses lung cancer metastasis through the regulation of EMT progress [0.03%]
由PTEN生成的长链非编码RNA LncPTEN1通过调节上皮间质转化进程抑制肺癌转移
Zichu Shen,Ailin Zhong,Chun Zhang et al.
Zichu Shen et al.
Lung cancer is among the most frequently observed and lethal malignancies globally, and metastasis represents a critical determinant of patient outcomes. PTEN, a well-established tumor suppressor, has emerged as an important regulator in lu...
MiR-92a-1-5p contributes to cellular proliferation and survival in chronic myeloid leukemia and its inhibition enhances imatinib efficacy [0.03%]
微小核糖核酸-92a-1-5p促进慢性粒细胞白血病细胞增殖和存活并可增强伊马替尼的疗效
Joanne Peters,Emeline Bollaert,Anne-Sophie Cloos et al.
Joanne Peters et al.
Tyrosine kinase inhibitors (TKI), such as imatinib, have revolutionized chronic myeloid leukemia (CML) treatment. Despite this success, TKI intolerance and resistance remain significant clinical challenges. A promising therapeutic approach ...
Exosome-derived hsa_circ_0007132 promotes lenvatinib resistance by inhibiting the ubiquitin-mediated degradation of NONO [0.03%]
外泌体衍生的hsa_circ_0007132通过抑制NONO的泛素化降解促进仑伐替尼耐药性
Mingbo Cao,Yuxuan Li,Xiaorui Su et al.
Mingbo Cao et al.
Hepatocellular carcinoma (HCC) is a highly heterogeneous solid tumor, with its incidence showing a troubling upward trend over the past decade. Lenvatinib is one of the first-line medications for treating advanced HCC, however, the developm...
Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer [0.03%]
选择性转录增加长非编码RNA的异构体复杂性和其在癌症中的功能作用
Max Bone,Gareth J Inman
Max Bone
Transcriptional start and end variance, a less-explored aspect of lncRNA biology, is a critical determinant of isoform diversity in human RNA. While alternative splicing (AS) has been extensively studied as a mechanism of isoform generation...
Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization [0.03%]
舌鳞癌来源的外泌体miR-21-5p通过促进M2型巨噬细胞极化影响肿瘤进展
Zixian Xu,Xin Fang,Shan Wang et al.
Zixian Xu et al.
Exosome-mediated intercellular communication plays a key role in shaping the tumor microenvironment and promoting tumor progression. Recent studies have demonstrated that tumor exosomal miRNAs significantly contribute to the polarization of...
Role of Ocrelizumab in modulating gene and microRNA expression in multiple sclerosis [0.03%]
奥马珠单抗在调节多发性硬化基因和微小核糖核酸表达中的作用
Bruna De Felice,Elisabetta Signoriello,Concetta Montanino et al.
Bruna De Felice et al.
Multiple sclerosis is an autoimmune neurodegenerative disease and one of the most significant challenges in modern neurology, impacting approximately 2.8 million people globally. As a multifactorial condition, susceptibility to MS can resul...
Maternal plasma microRNAs as potential biomarkers for triaging pregnancies of unknown location and ectopic pregnancy diagnosis [0.03%]
母体血浆微小核糖核酸作为甄别不明位置妊娠和异位妊娠的潜在生物标志物研究
Christopher Kyriacou,Sung Hye Kim,Maria Arianoglou et al.
Christopher Kyriacou et al.
Background: Pregnancy of unknown location (PUL) is classified if an early pregnancy is not visualised on transvaginal ultrasonography (TVUS). Biomarkers currently used to triage PUL outcomes have varying accuracy. Delayed...
The emerging role of miRNAs in biological aging and age-related diseases [0.03%]
microRNA在生物衰老及与年龄有关的疾病中作用机制的研究进展
Rawad Turko,Amro Hajja,Ahmad M Magableh et al.
Rawad Turko et al.
Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes. Despite data showing that lifestyle mo...