MicroRNA-21-3p regulation of NADPH oxidase 4 and vascular endothelial growth factor A contributes to hemorrhage in cerebral cavernous malformations [0.03%]
microRNA-21-3p通过调节NADPH氧化酶4和血管内皮生长因子A参与脑海绵状血管畸形出血发病机制
Xin-Xing Guo,Zhong-Run Huang,Pei-Sheng Chen et al.
Xin-Xing Guo et al.
Background: Cerebral cavernous malformations (CCMs) are vascular anomalies prone to hemorrhage, leading to neurological deficits and reduced quality of life. Current therapies are limited, and molecular mechanisms underly...
MiR-199a-3p deficiency induced by STAT3 activation drives smooth muscle cell phenotypic switching in pulmonary arterial hypertension [0.03%]
STAT3激活诱导的MiR-199a-3p缺乏驱动肺动脉高压中的平滑肌细胞表型转换
Wen-Xia He,Yun-Jie Huang,Tian-Hong Ai et al.
Wen-Xia He et al.
Pulmonary arterial hypertension (PAH) is a progressive vasculopathy characterized by pathological vascular remodeling, in which pulmonary artery smooth muscle cells (PASMCs) undergo phenotypic switching from a contractile to a synthetic sta...
Identification of long non-coding RNAs involved in leukemogenesis and venetoclax response in acute myeloid leukemia through functional CRISPR-dCas9 interference screens [0.03%]
通过功能CRISPR-dCas9干扰筛选识别参与急性髓系白血病白血病发生和维奈克拉响应的长链非编码RNA
Elisabetta Cozzi,Anne Neddermeyer,Sophia Miliara et al.
Elisabetta Cozzi et al.
Acute myeloid leukemia (AML) is a malignant hematologic disease with poor prognosis, and improved understanding of its biology is critical for patient outcomes. While protein-coding genes in AML are well characterized, the role of long non-...
LncRNA MIR22HG and miR-10a-5p: Pioneering serum biomarkers for pancreatic cancer diagnosis and progression assessment [0.03%]
长链非编码 RNA MIR22HG 和 microRNA-10a-5p：胰腺癌诊断和病情评估的先锋血清生物标志物
Rowyda M Salman,Abdullah F Radwan,Olfat G Shaker et al.
Rowyda M Salman et al.
Background: Pancreatic cancer (PC) endures as one of the most lethal malignancies, characterized by a dismal prognosis due to late-stage detection and limited therapeutic options. Circulating noncoding RNAs (ncRNAs) play ...
CRISPR decodes the RNA regulatory network in prostate cancer: A review from mechanisms to precision therapeutics [0.03%]
CRISPR技术解码前列腺癌RNA调控网络：从机制到精确诊疗综述
Song Zhu,Gao Ni,Pinjie Zhang et al.
Song Zhu et al.
Prostate cancer (PCa) remains one of the most prevalent and lethal malignancies in men worldwide. The pronounced heterogeneity and therapeutic resistance of PCa underscore the critical need to decipher its RNA regulatory network for advanci...
tRNA-derived small RNAs in ocular neovascular diseases: A systematic review [0.03%]
眼部新生血管疾病中由tRNA衍生的小RNA的研究：系统综述
Tian-Yi Liu,Peng-Zhou Kuai,Yi-Sheng Luo et al.
Tian-Yi Liu et al.
Ocular neovascular diseases (ONDs) are a leading cause of global blindness. While current anti-vascular endothelial growth factor (VEGF) treatments have revolutionized management, their efficacy is constrained by issues such as non-response...
Discovery of a G-rich ultra stable human ncRNA G-quadruplex that binds ATP [0.03%]
人类ncRNA G-四链体的发现：G-富集、超稳定并与ATP结合
Margaret Bohmer,Kai Jin,Peixuan Guo
Margaret Bohmer
Thermostable RNA motifs have been shown to be a unique material for building nanoparticles for many applications (Guo lab, Nature Nanotechnology, 2020 PMID: 21102465; 2021 PMID: 21909084). Here, we report the discovery of a G-rich ultra-sta...
Functional role of long non-coding RNA MALAT1 and HOTAIR in lung cancer [0.03%]
长非编码RNA MALAT1和HOTAIR在肺癌中的功能作用
Hong-Wei Wen,Ali Afzal,Guang-Wei Chen et al.
Hong-Wei Wen et al.
Long noncoding RNAs, particularly MALAT1 and HOTAIR, play a key role in regulating tumorigenesis, and therapeutic response. Current literature indicates their influence on key oncogenic pathways. Yet, the literature remains fragmented and l...
Targeting non-coding RNAs in the ferroptosis system: Molecular mechanisms and clinical translation for reversing doxorubicin resistance in breast cancer [0.03%]
靶向铁死亡调控非编码RNA：逆转多柔比星耐药的乳腺癌治疗中的分子机制及临床转化研究
Xiaojie Yu,An Xu,Longdi Yao et al.
Xiaojie Yu et al.
Breast cancer remains one of the leading causes of cancer-related morbidity and mortality in women worldwide, and the clinical efficacy of doxorubicin (DOX) is frequently compromised by chemoresistance. Ferroptosis, an iron-dependent form o...
The pachytene-specific lncRNA 1700008K24Rik is essential for mouse spermatogenesis and functions as a conserved piRNA precursor [0.03%]
长链非编码RNA 1700008K24Rik对小鼠精子发生是必需的，并且是一种保守的piRNA前体
Shikun Jian,Xu Han,Chenyao Xie et al.
Shikun Jian et al.
Spermatogenesis is a complex differentiation process requiring precise spatiotemporal gene regulation, yet the functions of most testis-enriched long noncoding RNAs (lncRNAs) remain elusive. Here, we identify 1700008K24Rik as a pachytene-sp...