Long non-coding RNA AK023617 orchestrates atherosclerosis by regulating the circadian rhythm of immunity-related GTPase family M protein in macrophages [0.03%]
长非编码RNA AK023617通过调节巨噬细胞中免疫相关GTP酶家族M蛋白的昼夜节律来调控动脉粥样硬化
Rongzhe Lu,Hengxuan Cai,Yige Liu et al.
Rongzhe Lu et al.
Acute coronary events show a diurnal rhythm, and atherosclerotic plaque vulnerability, as a histomorphological characteristic of major adverse cardiovascular events, is a key target for intervention. Although oscillating microRNAs reduce pl...
Serum/glucose starvation enhances binding of miR-4745-5p and miR-6798-5p to HNRNPA1 mRNA 3'UTR: A novel method to identify miRNAs binding to mRNA 3'UTR using λN peptide-boxB sequence [0.03%]
血清/葡萄糖饥饿可增强miR-4745-5p和miR-6798-5p与HNRNPA1 mRNA 3'UTR结合：使用λN肽-boxB序列识别miRNA与mRNA 3' UTR结合的新型方法
Tetsuyuki Takahashi,Mai Funamura,Shun Wakai et al.
Tetsuyuki Takahashi et al.
Serum/glucose starvation causes complete loss of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) without altering mRNA levels. However, the mechanisms driving hnRNP A1 downregulation during serum/glucose starvation are not yet well un...
LncRNA NEAT1-206 regulates autophagy of human umbilical cord mesenchymal stem cells through the WNT5A/Ca2+ signaling pathway under senescence stress [0.03%]
长非编码RNA NEAT1-206通过WNT5A/Ca2+信号通路调节人类脐带间充质干细胞衰老应激下的自噬作用
Weili Wang,Yongyu Wang,Chunchun Duan et al.
Weili Wang et al.
Stem cells are crucial for maintaining bodily stability, but their regenerative abilities decline with age. This decline is marked by reduced proliferation and differentiation capacities of stem cells, as well as exhaustion of the stem cell...
Xu Qian,Yongwei Jiang,Yadi Yang et al.
Xu Qian et al.
MicroRNA (miRNA) is broadly manifested in eukaryotes and serves as a critical function in biological development and disease occurrence. With the rapid advancement of experimental research tools, researchers have discovered functional corre...
The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis [0.03%]
tRNA衍生的小分子RNA(tsRNA)在胰腺癌和急性胰腺炎中的作用研究进展
Yan Pan,Xiaowei Ying,Xueting Zhang et al.
Yan Pan et al.
tRNA-derived small RNAs (tsRNAs), encompassing tRNA fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs), represent a category of non-coding small RNAs (sncRNAs) that are increasingly recognized for their diverse biological functi...
The role of long non-coding RNAs in cardiovascular diseases: A comprehensive review [0.03%]
长非编码RNA在心血管疾病中的作用：综述
Xuena Xie,Meiwen Huang,Shudong Ma et al.
Xuena Xie et al.
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular mechanisms underlying CVDs are not yet ...
Inhibition of MALAT1 facilitates ROS accumulation via the Keap1/HO-1 pathway to enhance photodynamic therapy in secondary hyperparathyroidism [0.03%]
MALAT1抑制通过Keap1/HO-1通路促进ROS积累以增强继发性甲状旁腺功能亢进症的光动力疗法
Ying Wen,Yitong Li,Danhua Zhang et al.
Ying Wen et al.
The prevalence of secondary hyperparathyroidism (SHPT) in advanced chronic kidney disease (CKD) exceeds 80 %. Our previous study indicated that photodynamic therapy (PDT) has potential for treating SHPT. Long noncoding RNA (lncRNA) is invol...
Identification and validation of lncRNA mutation hotspot SNPs associated with myasthenia gravis susceptibility [0.03%]
与重症肌无力易感性相关的长链非编码 RNA (lncRNA) 突变热点 SNP 的鉴定和验证
Ni He,Liting Tian,Jingnan Jin et al.
Ni He et al.
Background: Myasthenia gravis (MG) is an autoimmune disorder caused by antibodies that target the postsynaptic muscle membrane. Recent evidence suggests that genetic variants and long noncoding RNAs (lncRNAs) play crucial...
Expression of miR-15b-5p and toll-like receptor4 as potential novel diagnostic biomarkers for hepatitis C virus-induced hepatocellular carcinoma [0.03%]
miR-15b-5p和 Toll样受体4表达作为潜在新型诊断生物标志物在丙型肝炎病毒诱导的肝细胞癌中的表达
Amal Ahmed Mohamed,Noha Nagah Amer,Noha Osama et al.
Amal Ahmed Mohamed et al.
Objectives: Globally, hepatocellular Carcinoma (HCC) ranks seventh in women's cancer and fifth in men's cancer. Early identification can minimize mortality and morbidity. MicroRNAs and Toll-like receptors have been sugges...
Targeting microRNA methylation: Innovative approaches to diagnosing and treating hepatocellular carcinoma [0.03%]
靶向microRNA甲基化：诊断和治疗肝细胞癌的创新方法
Albert Sufianov,Murad Agaverdiev,Andrey Mashkin et al.
Albert Sufianov et al.
Hepatocellular carcinoma (HCC) stands as the most prevalent form of primary liver cancer and is frequently linked to underlying chronic liver conditions such as hepatitis B, hepatitis C, and cirrhosis. Despite the progress achieved in the f...