Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 [0.03%]
长非编码RNA LINC00339通过结合PARP1调节CDC42促进骨质疏松的发展
Dong-Li Zhu,Yan Zhang,Xiao-Yu Zhang et al.
Dong-Li Zhu et al.
Background: Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration of bone tissue. Our previous investigation provided preliminary evidence that single nucleot...
LncRNA MIR155HG suppresses cell apoptosis by activating autophagy via miR-7036b-3p/GPNMB axis and AMPK/mTOR signaling in spinal cord injury [0.03%]
长链非编码RNA MIR155HG通过miR-7036b-3p/GPNMB轴和AMPK/mTOR信号抑制脊髓损伤中的细胞凋亡
Ruoxi Liu,Jintao Ye,Sihua Huang
Ruoxi Liu
Background: Long non-coding RNAs (lncRNAs) participate in spinal cord injury (SCI) development through regulating autophagy and neuronal apoptosis. Previously, MIR155HG was identified as an upregulated lncRNA in rat bladd...
Dual role of lncRNA OTUD6B-AS1 in immune evasion and ferroptosis resistance: A prognostic and therapeutic biomarker in breast cancer [0.03%]
长链非编码RNA OTUD6B-AS1在免疫逃逸和铁死亡抵抗中的双重作用：乳腺癌预后和治疗生物标志物
Jia-Ning Zhang,Zi-Lu Yi,Xi-Rui Zhou et al.
Jia-Ning Zhang et al.
Background: Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in tumorigenesis and therapeutic resistance. This study investigates the prognostic significance and dual biological functions of lncRNA OTUD6B...
Serum lncRNAs NEAT1, PVT1 and H19 as novel biomarkers for sarcopenia diagnosis and treatment response [0.03%]
血清长链非编码RNA NEAT1、PVT1和H19作为新的肌少症诊断和治疗反应生物标志物
Paula Aparicio,Tresa López-Royo,David Navarrete-Villanueva et al.
Paula Aparicio et al.
Sarcopenia, the loss of muscle mass and function generally associated to age, leads to increased dependence and mortality in older adults. Despite its clinical significance, unclear molecular mechanisms hinder the development of universal d...
LncRNA levels in the central nervous system as novel potential players and biomarkers in amyotrophic lateral sclerosis [0.03%]
中枢神经系统中长链非编码RNA的水平可作为肌萎缩性侧索硬化的新潜在作用因子和生物标志物
Tresa López-Royo,Laura Moreno-Martínez,Gabriel Rada et al.
Tresa López-Royo et al.
Research in amyotrophic lateral sclerosis (ALS) faces major burdens, including the urgent need for sensitive and specific biomarkers, the identification of novel and effective therapeutic targets and a deeper understanding of the mechanisms...
Deciphering the multifaceted role of circular RNA in aging: from molecular mechanisms to therapeutic potentials [0.03%]
环状RNA在衰老中的作用：从分子机制到治疗潜力
Yang Wang,Cong Wang,Xin Dai et al.
Yang Wang et al.
Aging is an inevitable physiological process that occurs in living organisms and has significant implications for health and disease. As the human lifespan extends, the functionality of organs gradually diminishes, leading to the emergence ...
LncRNA MEG3/CTCF-CXCR4 axis functions in the regulation of breast cancer cell migration [0.03%]
长链非编码RNA MEG3/CTCF-CXCR4轴在乳腺癌细胞迁移中的作用研究
Gusai Elhassan,Xiangxue Bu,Jiaxin Liu et al.
Gusai Elhassan et al.
Loss or decreased expression of lncRNA MEG3 is a frequent event in the progression of many different malignancies. Overexpression of MEG3 in breast cancer cell lines MCF7 or MDA-MB-231 prevented cell migration, whereas depletion of MEG3 in ...
The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications [0.03%]
结直肠癌中微小核糖核酸的多面体作用：发病机制和治疗意义
Federica Longo,Giuseppe Gattuso,Graziana Spoto et al.
Federica Longo et al.
MicroRNAs (miRNAs) are important regulators of gene expression and their dysregulation is involved in various diseases, including tumors. Among these, colorectal cancer (CRC) is the result of both genetic and epigenetic alterations with miR...
Computational discovery of conserved RNA structures and functional characterization of a structured lncRNA in Leishmania braziliensis [0.03%]
利什曼原虫中保守的RNA结构的计算发现和长链非编码RNA功能表征
Caroline R Espada,Christian Anthon,Rubens D M Magalhães et al.
Caroline R Espada et al.
Leishmania parasites alternate between hosts, facing environmental changes that demand rapid gene expression adaptation. Lacking canonical RNA polymerase II promoters, transcription in these eukaryotes is polycistronic, with gene regulation...
Upregulation of LINC02154 promotes esophageal cancer progression by enhancing cell cycling and epithelial-mesenchymal transition [0.03%]
LINC02154上调通过增强细胞周期和上皮间质转化促进食管癌进展
Kotoha Shimote,Takeshi Niinuma,Hiroshi Kitajima et al.
Kotoha Shimote et al.
Long noncoding RNAs (lncRNAs) play crucial roles in the progression of human malignancies; however, their involvement in esophageal cancer (ESCA) remains incompletely understood. In this study, we screened for lncRNAs upregulated in ESCA an...