miR-129-1-3p down-regulation promotes BAG cochaperone 3 (BAG3)-driven pro-fibrotic processes in primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa [0.03%]
微RNA-129-1-3p低表达促进BAG分子 chaperone 3(BAG3)驱动的原发成纤维细胞向促纤维化方向发展
Rebecca Nobili,Cristina Barbagallo,Marco Ragusa et al.
Rebecca Nobili et al.
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare and severe skin fragility disease due to loss-of-function mutations in the COL7A1 gene. RDEB patients suffer from relentless mucocutaneous blisters that evolve into chronic wounds ...
AutoML identification of microRNA biomarkers in high-risk pediatric acute lymphoblastic leukemia [0.03%]
基于AutoML的高危儿童急性淋巴细胞白血病microRNA标志物识别研究
Ioannis Kyriakidis,Zacharias Papadovasilakis,Georgios Papoutsoglou et al.
Ioannis Kyriakidis et al.
Despite significant advancements in overall survival rates for childhood acute lymphoblastic leukemia (ALL), relapse continues to pose a major challenge. MicroRNAs have proven valuable for improving diagnosis, treatment, and survival outcom...
Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker [0.03%]
血清和血浆中microRNA的稳定性表明其可作为循环生物标志物
Erryk S Katayama,Jonathan J Hue,Alexander W Loftus et al.
Erryk S Katayama et al.
Purpose: To verify the stability and reliability of circulating microRNA (miRNA) profiles in plasma and serum under different processing and storage conditions to inform future applications to circulating biomarker analys...
Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker [0.03%]
非病毒性肝细胞癌的miRNA谱分析确定miR-1972为潜在的良好预后标志物
Venkata Ramana Mallela,Marie Rajtmajerová,Esraa Ali et al.
Venkata Ramana Mallela et al.
Background & aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-cat...
Progenitor cells, microglia, and non-coding RNAs: Orchestrators of glioblastoma pathogenesis and therapeutic resistance [0.03%]
前体细胞、小胶质细胞和非编码RNA：胶质母细胞瘤发病机制及治疗耐药性的调控者
Adil Husain,Firoz Ahmad,Sandeep Pandey et al.
Adil Husain et al.
Glioblastoma (GB) remains a major challenge owing to its extremely aggressive nature and resistance to conventional therapies. This review focuses on the intricate roles of progenitor cells, microglia, and non-coding RNAs (ncRNAs) in orches...
LncRNA MYO16-AS1 and MICAL2 axis sustains proliferation and migration in ovarian cancer cells and unveils a therapeutic vulnerability in patient-derived tumor organoids [0.03%]
长链非编码RNA MYO16-AS1和MICAL2轴维持卵巢癌细胞的增殖和迁移，并在患者来源肿瘤类器官中揭示了治疗弱点
Mohammad Ahmad,Lucie Thorel,Emilie Brotin et al.
Mohammad Ahmad et al.
Ovarian carcinoma (OC) exhibits a 5-year survival rate of below 40 %, mainly due to late-stage diagnosis and recurrence associated to resistance to chemotherapy. Long noncoding RNAs (lncRNAs) are involved in numerous cellular processes of c...
Emerging roles of tsRNAs in programmed cell death and disease therapeutics: challenges, opportunities, and future directions [0.03%]
tsRNA在程序性细胞死亡及疾病治疗中的新兴作用：挑战、机遇和未来方向
Zhe Li,Bo Zhang,Yanru Pan et al.
Zhe Li et al.
Programmed cell death (PCD), which includes various forms such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, plays a pivotal role in disease pathogenesis and progression. tRNA-derived small RNAs (tsRNAs) have emerged as...
The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis [0.03%]
血浆外泌体miR-15a-5p靶向CF修饰蛋白IGF1R调控肺泡上皮细胞自噬影响肺间质纤维化的机制研究
Yina Li,Nan Wang,Jinying Hu et al.
Yina Li et al.
Aims: This study investigates how plasma exosomal miRNAs regulate core fucosylation (CF)-modified targets to influence autophagy and fibrosis in idiopathic pulmonary fibrosis (IPF), aiming to identify novel therapeutic st...
Xia Cai,Hui Shan,Jiaojiao Wang et al.
Xia Cai et al.
Small RNAs (sRNAs) are widely used by bacteria to regulate diverse biological processes. Although they are generally considered "non-coding", some sRNAs (called dual-function sRNAs) have been found to encode small proteins, which are usuall...
5'tiRNA-Glu-TTC targets TRPV3 and activates the PI3K/AKT signaling pathway to modulate skin photoaging [0.03%]
5' tiRNA-Glu-TTC靶向TRPV3并激活PI3K/AKT信号通路以调节皮肤光老化
Zhuohong Xu,Lihao Liu,Xiaoxi Dai et al.
Zhuohong Xu et al.
tRNA-derived small RNAs (tsRNAs), a class of non-coding RNAs (ncRNAs), have garnered increasing research interest for their potential roles in various biological processes. Among these, 5'tiRNA-Glu-TTC has been implicated in aging, but its ...