Identification of plasma tRNA-derived small RNA i-tRF-15:31-Lys-CTT-1 as a biomarker for diagnosis and prognosis of pulmonary arterial hypertension [0.03%]
血浆tRNA衍生的小RNA i-tRF-15:31-Lys-CTT-1作为诊断和预后肺动脉高压生物标志物的鉴定
Yusi Chen,Tengteng Zhu,Fang Li et al.
Yusi Chen et al.
Introduction: tRNA-derived small RNAs (tsRNAs) are emerging as noninvasive biomarkers of cellular damage. However, their role in pulmonary arterial hypertension (PAH) remains unclear. ...
ncFN: a comprehensive non-coding RNA function annotation framework based on a global and heterogeneous biomolecular network [0.03%]
基于全局异构生物分子网络的全面非编码RNA功能注释框架
Min Long,Haizhou Liu,Mengqin Yuan et al.
Min Long et al.
Increasing evidence indicates that non-coding RNAs (ncRNAs) have emerged as essential factors in most biological processes through diverse mechanisms. However, the biological functions of most ncRNAs are still poorly understood. Here, we de...
LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance [0.03%]
lncRNA-EME1增强BRCA1的募集并改变宫颈癌放射耐受性的DNA修复路径
Qing Li,Zhenyu Zhou,Xiaoying Li et al.
Qing Li et al.
Background: Cervical cancer is a significant cause of mortality in women globally, and radioresistance limits the effectiveness of standard radiotherapy treatment. Exploring the molecular mechanisms that contribute to rad...
AQUARIUM_HB: a bioinformatics pipeline for human blood circular RNA analysis [0.03%]
Aquarium_HB：人类血液环状RNA分析生物信息学管道
Shaoxun Yuan,Xue Bai,Linwei Li et al.
Shaoxun Yuan et al.
Accurately identifying and quantifying human blood circular RNAs (circRNAs) from RNA-seq data is a critical bioinformatics challenge in biomarker discovery for human diseases. In this study, we present AQUARIUM-HB, a comprehensive bioinform...
Long non-coding RNAs in B-cell acute lymphoblastic leukemia: Disease implication, challenges and therapeutic opportunities [0.03%]
B细胞急性淋巴细胞白血病中的长链非编码RNA：疾病影响、挑战与治疗机会
Devesh Srivastava,Ashish Misra
Devesh Srivastava
B-cell acute lymphoblastic leukemia (B-ALL) manifests as an abnormal proliferation of neoplastic B-cell lymphocytes, adversely affecting both children and adults. Despite the advancements in cancer research, B-ALL cure remains challenging d...
Non-coding RNAs in congenital heart disease and placental development: Bridging molecular mechanisms to clinical biomarkers and therapies [0.03%]
非编码RNA在先天性心脏病和胎盘发育中的作用：从分子机制到临床生物标志物和治疗
Haoxuan Wang,Xinzhe Chen,Yinghui Li et al.
Haoxuan Wang et al.
Non-coding RNAs (ncRNAs) have emerged as pivotal regulators of gene expression, orchestrating embryonic development and disease pathogenesis. This review synthesizes current knowledge on the origin, biogenesis, and functional diversity of n...
Circadian rhythm-related miR-6883-5p suppresses enzalutamide-resistant prostate cancer [0.03%]
与昼夜节律相关的miR-6883-5p抑制恩杂鲁胺耐药性前列腺癌
Wenchang Yue,Chao Li,Tao Wang et al.
Wenchang Yue et al.
The increasing incidence of prostate cancer (PCa), particularly the emergence of treatment-resistant castration-resistant prostate cancer (CRPC), has intensified research efforts to address this lethal disease. Circadian rhythm gene alterat...
Exosome-like nanovesicles from Dunaliella salina efficient sequential Co-delivery of anti-PDL1 and miR-375 for enhancing gene/immune therapy [0.03%]
盐藻类囊体高效递送抗PDL1和miR-375的基因/免疫治疗
Zhaoyi Wei,Mengxi Zhu,Shan Li et al.
Zhaoyi Wei et al.
Background: Esophageal cancer is one of the common malignant tumors of digestive system. Despite many advances in the treatment of esophageal cancer, many challenges remain. As an endogenous extracellular vesicle, exosome...
miRNA-195-5p modulates cell proliferation and stemness by targeting the Wnt signalling network in breast cancer [0.03%]
microRNA-195-5p通过靶向Wnt信号通路网络调控乳腺癌细胞增殖和干性
Sanjeev Kumar,Neeru Saini
Sanjeev Kumar
Cancer stem cells (CSCs) are a specific subpopulation of cells within the tumour characterised by self-renewal, proliferation and tumorigenic potential. Heterogeneity in the CSCs population and their ability to rewire the signalling network...
NSUN2-mediated m5C hypermethylation of hsa_circ_0004516 promotes breast cancer brain metastasis by activating AKT signaling [0.03%]
NSUN2介导的hsa_circ_0004516m5C高甲基化通过激活AKT信号促进乳腺癌脑转移
Min Li,Jiawei Li,Hongbo Wen et al.
Min Li et al.
Breast cancer brain metastasis (BCBM) remains fatal with elusive mechanisms. Here, we unveil the first circRNA m5C methylation landscape in BCBM through MeRIP-seq (methylated RNA immunoprecipitation next-generation sequencing) identifying 7...