TPR is required for circRNA, lncRNA and mRNA nuclear export [0.03%]
TPR介导的环状RNA、长链非编码RNA和信使RNA的核输出转运功能研究
Min Zhou,Ruirui Jia,Mengya Gao et al.
Min Zhou et al.
Background: Efficient RNA nuclear export is essential for proper cellular function and normal physiology, with defects in this process leading to pathological consequences. Our study aimed to investigate the role of trans...
Integrative analysis of tissue and circulating miRNAs as biomarkers for progression and survival in hepatocellular carcinoma [0.03%]
肝细胞癌进展和生存的组织和循环miRNA生物标志物的综合分析
Abdullah Jabri,Abdulaziz Mhannayeh,Mohamed Alsharif et al.
Abdullah Jabri et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with limited biomarkers available for early diagnosis and risk stratification. In this study, we performed an integrative analysis of tissue and circulating micr...
Illustration of the variable 1D sequences but conserved 2D and 3D structures of different ncRNA nanostructures for tracking the evolution and origin of organisms [0.03%]
不同ncRNA纳米结构的可变一维序列但保守的二维和三维结构的图示，以追踪有机物的进化和起源
Kai Jin,Margaret Bohmer,Peixuan Guo
Kai Jin
Viruses and other microorganisms are constantly mutating and emerging in different regions. Here, we apply nanotechnology to examine the primary, secondary, and tertiary structures of novel noncoding RNA nanoparticles and find that primary ...
MiR-21 modulates P.g- LPS induced apoptosis and inflammatory response in HUVECs via NF-κB/iNOS/NO pathway by targeting PDCD4 [0.03%]
miR-21通过靶向PDCD4调控NF-κB/iNOS/NO途径介导的牙龈卟啉单胞菌脂多糖诱导的人脐静脉内皮细胞凋亡和炎症反应
Jing Ren,Huiqiong Zou,Siyu Sun et al.
Jing Ren et al.
Background: Porphyromonas gingivalis lipopolysaccharide (P.g-LPS), a key virulence factor in periodontitis, contributes to systemic vascular diseases, notably atherosclerosis. MicroRNA-21 (miR-21), a critical post-transcr...
Small RNA sequencing in individually selected sperm: Biomarkers for male subfertility and predictors of pregnancy success [0.03%]
单个精子的小RNA测序：男性不育的生物标志物及妊娠成功的预测指标
Mohammad A Al Smadi,Haidar Haidar,Albert Salas-Huetos et al.
Mohammad A Al Smadi et al.
Background: Sperm quality defined by motility and morphology has critical implications for fertility and pregnancy outcomes. Small RNAs, including microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs), play regulatory rol...
LncRNA expression in prostate cancer: From in silico analysis to urinary EV-based liquid biopsy for prognosis [0.03%]
前列腺癌中的长链非编码RNA表达：从计算机分析到尿液EV基的液体活检以预测预后
Simona De Summa,Letizia Porcelli,Giuseppe De Palma et al.
Simona De Summa et al.
Prostate cancer (PCa) is the most frequently diagnosed malignancy among men and remains a leading cause of cancer-related death. Despite the widespread use of diagnostic tools such as PSA testing and Gleason scoring, these methods often fal...
miR-6850 drives phenotypic changes and signaling in high grade serous ovarian cancer [0.03%]
miR-6850通过调节信号通路驱动高级别浆液性卵巢癌的表型变化
Kamil Filipek,Daniela Pollutri,Ivana Kurelac et al.
Kamil Filipek et al.
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression, and their dysregulation is closely linked to cancer development. Ovarian cancer (OC), particularly the high-grade serous ovarian carcinoma (HGSOC) subtype, is th...
Keratinocyte-specific long non-coding RNA NR037661 controls alternative splicing of ANGPTL4 to induce keratinocyte differentiation [0.03%]
角质细胞分化诱导因子ANGPTL4的可变剪接调控长链非编码RNA NR037661的鉴定及功能研究
Chunxiao Li,Qinyuan Zhu,Xinhang Cao et al.
Chunxiao Li et al.
Background: Aberrant differentiation of keratinocytes has been implicated in various skin diseases. However, the impact of lncRNA on keratinocyte differentiation and RNA alternative splicing remains poorly understood. The...
circMRPL35 promotes gastric cancer progression through the miR-6809-3p/ZNF90 axis and affects the EMT process and TGF-β1/SMAD2/3 signaling [0.03%]
circMRPL35通过miR-6809-3p/ZNF90轴促进胃癌进展并影响EMT过程和TGF-β1/SMAD2/3信号通路
Xiuping Wang,Zhendong Yao,Yu Liu et al.
Xiuping Wang et al.
Background: Circular RNAs (circRNAs) have been implicated in developing gastric cancer (GC). However, the role of circMRPL35 in GC remains unknown. Method...
Aerobic exercise alleviates allergic airway inflammation by suppressing circMETTL9-mediated formation of macrophage extracellular traps [0.03%]
有氧运动通过抑制circMETTL9介导的巨噬细胞胞外陷阱形成来缓解过敏性气道炎症
Haixia Wang,Ting Gao,Bin Ma et al.
Haixia Wang et al.
Emerging evidence suggests that aerobic exercise exerts beneficial effects on asthma. Previous studies have demonstrated that cell communication can drive the formation of macrophage extracellular traps (METs). However, the potential of aer...