Xiaoyu Ma,Jiesi Xu,Guoping Li
Xiaoyu Ma
Cell death is essential for maintaining physiological homeostasis and regulating pathological processes. tRNA-derived small RNAs (tsRNAs), an emerging non-coding small RNA, play key roles in a various form of cell death. The relationship be...
Circ_0054633 silencing suppresses hyperglycemia-induced extracellular matrix accumulation in renal mesangial cells by regulating MiR-136-5p/SMAD3 signaling [0.03%]
circ_0054633通过调控miR-136-5p/SMAD3信号抑制高糖诱导的肾系膜细胞外基质蓄积
Qing Jiang,Hongxin Chen,Ke Wang et al.
Qing Jiang et al.
Diabetic kidney disease (DKD) is the most common complication of diabetes mellitus (DM), with excessive deposition of the extracellular matrix (ECM) produced by glomerular mesangial cells being its critical hallmark. circ_0054633, a circula...
Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells [0.03%]
棕榈酸通过降低肝癌细胞中LDLR依赖性摄取巨噬细胞源外泌体而减少胆固醇摄取
Bootsakorn Boonkaew,Nantawat Satthawiwat,Bianca C Pachane et al.
Bootsakorn Boonkaew et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by a complicated interaction of lipotoxicity and inflammation in the liver, yet the mechanisms linking these phenomena remain incompletely understood. In this...
The role of non-coding RNA regulates stem cell programmed death in disease therapy [0.03%]
非编码RNA在调控干细胞程序性死亡的疾病治疗作用
Ziling Liao,Weidong Liu,Lei Wang et al.
Ziling Liao et al.
Programmed cell death (PCD), an essential and inevitable phenomenon, is integral to organismal development. It not only maintains cellular homeostasis but also prevents aberrant cell proliferation, thereby protecting normal growth and devel...
The mechanism by which MALAT1/CREG1 regulates premature rupture of fetal membrane through autophagy mediated differentiation of amniotic fibroblasts [0.03%]
lncRNA MALAT1/CREG1通过自噬介导的羊膜成纤维细胞分化在胎膜早破的发生发展中的机制研究
Xiaomei Huang,Ting Huang,Aixing Chen et al.
Xiaomei Huang et al.
Background: Premature rupture of fetal membrane (PROM) is one of the main causes of premature delivery. The amniotic membrane plays a major role in bearing weight, and amniotic fibroblasts play an important role. The purp...
HNRNPC stabilizes m6A-modified AC145207.5 to accelerate tumorigenesis in colorectal cancer by impeding the Nrf2/GPX4 axis-mediated ferroptosis [0.03%]
HNRNPC通过阻碍Nrf2/GPX4轴介导的铁死亡来稳定mRNA N6-甲基腺苷修饰的AC145207.5以加速结直肠癌肿瘤发生发展
Dan Liu,Shanshan Lin,Yueben Hu et al.
Dan Liu et al.
Ferroptosis is an apoptosis-independent cell death pathway characterized by heightened lipid peroxidation, which shows promise for tumor suppression. Despite extensive research on long non-coding RNAs (LncRNAs) in ferroptosis, their role in...
LINC02679 regulates TRIML2 to promote gastric cancer proliferation and invasion via targeting miR-5004-3p [0.03%]
LINC02679通过靶向miR-5004-3p调节TRIML2促进胃癌增殖和侵袭
Yingying Wang,Wenbo Liu,Xiaohan Zhao et al.
Yingying Wang et al.
As a key protein, Tripartite motif family-like 2 (TRIML2) is crucial to the p53-mediated apoptosis and is correlated with tumorigenesis. Emerging evidence showed that long non-coding RNAs (lncRNAs) play roles in the malignant progression of...
LncRNA-mRNA regulatory network reveals key lncRNAs tightly associated with preterm labor and premature rupture of membranes [0.03%]
长链非编码RNA-信使RNA调控网络揭示了与早产和胎膜早破密切相关的关键长链非编码RNA
Guangqiong Yang,Wenjin Qi
Guangqiong Yang
Premature rupture of membranes (PROM) and preterm birth (PTB) are significant pregnancy complications, accounting for approximately one-third of PTB, often preceded by preterm PROM (PPROM). The underlying causes of PROM and PTB are multifac...
Innovative approaches to metabolic dysfunction-associated steatohepatitis diagnosis and stratification [0.03%]
代谢功能紊乱相关steatohepatitis的诊断和分层的新方法
Marwa Matboli,Shaimaa Hamady,Maha Saad et al.
Marwa Matboli et al.
The global rise in Metabolic dysfunction-associated steatotic liver disease (MASLD)/Metabolic dysfunction-associated steatohepatitis (MASH) highlights the urgent necessity for noninvasive biomarkers to detect these conditions early. To addr...
The role of exosomal lncRNAs in cardiovascular disease: Emerging insights based on molecular mechanisms and therapeutic target level [0.03%]
外泌体长链非编码RNA在心血管疾病中的作用：基于分子机制和治疗靶点的新认识
Liyuan Zhao,Mengyun Gu,Zhimin Sun et al.
Liyuan Zhao et al.
Cardiovascular diseases (CVD) are widely recognized as a leading cause of death worldwide; however, early diagnosis and disease progression monitoring play a crucial role in their clinical management. The common diagnostic and prognostic bi...