MiR-92a-1-5p contributes to cellular proliferation and survival in chronic myeloid leukemia and its inhibition enhances imatinib efficacy [0.03%]
微小核糖核酸-92a-1-5p促进慢性粒细胞白血病细胞增殖和存活并可增强伊马替尼的疗效
Joanne Peters,Emeline Bollaert,Anne-Sophie Cloos et al.
Joanne Peters et al.
Tyrosine kinase inhibitors (TKI), such as imatinib, have revolutionized chronic myeloid leukemia (CML) treatment. Despite this success, TKI intolerance and resistance remain significant clinical challenges. A promising therapeutic approach ...
Exosome-derived hsa_circ_0007132 promotes lenvatinib resistance by inhibiting the ubiquitin-mediated degradation of NONO [0.03%]
外泌体衍生的hsa_circ_0007132通过抑制NONO的泛素化降解促进仑伐替尼耐药性
Mingbo Cao,Yuxuan Li,Xiaorui Su et al.
Mingbo Cao et al.
Hepatocellular carcinoma (HCC) is a highly heterogeneous solid tumor, with its incidence showing a troubling upward trend over the past decade. Lenvatinib is one of the first-line medications for treating advanced HCC, however, the developm...
Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer [0.03%]
选择性转录增加长非编码RNA的异构体复杂性和其在癌症中的功能作用
Max Bone,Gareth J Inman
Max Bone
Transcriptional start and end variance, a less-explored aspect of lncRNA biology, is a critical determinant of isoform diversity in human RNA. While alternative splicing (AS) has been extensively studied as a mechanism of isoform generation...
Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization [0.03%]
舌鳞癌来源的外泌体miR-21-5p通过促进M2型巨噬细胞极化影响肿瘤进展
Zixian Xu,Xin Fang,Shan Wang et al.
Zixian Xu et al.
Exosome-mediated intercellular communication plays a key role in shaping the tumor microenvironment and promoting tumor progression. Recent studies have demonstrated that tumor exosomal miRNAs significantly contribute to the polarization of...
Role of Ocrelizumab in modulating gene and microRNA expression in multiple sclerosis [0.03%]
奥马珠单抗在调节多发性硬化基因和微小核糖核酸表达中的作用
Bruna De Felice,Elisabetta Signoriello,Concetta Montanino et al.
Bruna De Felice et al.
Multiple sclerosis is an autoimmune neurodegenerative disease and one of the most significant challenges in modern neurology, impacting approximately 2.8 million people globally. As a multifactorial condition, susceptibility to MS can resul...
Maternal plasma microRNAs as potential biomarkers for triaging pregnancies of unknown location and ectopic pregnancy diagnosis [0.03%]
母体血浆微小核糖核酸作为甄别不明位置妊娠和异位妊娠的潜在生物标志物研究
Christopher Kyriacou,Sung Hye Kim,Maria Arianoglou et al.
Christopher Kyriacou et al.
Background: Pregnancy of unknown location (PUL) is classified if an early pregnancy is not visualised on transvaginal ultrasonography (TVUS). Biomarkers currently used to triage PUL outcomes have varying accuracy. Delayed...
The emerging role of miRNAs in biological aging and age-related diseases [0.03%]
microRNA在生物衰老及与年龄有关的疾病中作用机制的研究进展
Rawad Turko,Amro Hajja,Ahmad M Magableh et al.
Rawad Turko et al.
Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes. Despite data showing that lifestyle mo...
Characterization of small nucleolar RNA retaining transcripts in human normal and cancer cells [0.03%]
人正常和癌细胞中小核仁RNA滞留转录本的特征分析
Guglielmo Rambaldelli,Sidra Asghar,Giulia Venturi et al.
Guglielmo Rambaldelli et al.
Small nucleolar RNAs are non-coding RNAs typically encoded within the introns of both protein-coding and non-coding genes. Interestingly, a significant fraction of snoRNA sequences is found as retained introns of specific mRNA isoforms expr...
Uremic toxins levels are associated with miR-223 in chronic kidney disease-associated anemia [0.03%]
慢性肾脏病相关性贫血患者尿毒症毒素水平与miR-223的相关性研究
Emma Brisot,Pierre-Marie Leprêtre,Eya Hamza et al.
Emma Brisot et al.
Chronic kidney disease (CKD) poses a significant threat, with increased rates of cardiovascular and all-cause mortality. Anemia, common in CKD, is associated with accumulation of uremic toxins in the bloodstream. We previously demonstrated ...
CircRNA-based AntimiR therapy: A novel approach to hypertension treatment [0.03%]
基于环状circRNA的抗高血压疗法：一种治疗高血压的新方法
Vahideh Tarhriz,Kamran Hosseini,Leila Abkhooie et al.
Vahideh Tarhriz et al.
The increasing recognition of the types and functions of non-coding RNAs has opened new avenues for their use as novel therapeutic strategies in the treatment of chronic diseases such as hypertension. While most preclinical and clinical stu...