Mechanistic roles of long non-coding RNAs in gastric cancer therapy resistance [0.03%]
长非编码RNA在胃癌治疗抵抗中的作用机制
Jiayi Chen,Juanmei Gao
Jiayi Chen
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide. While gastrointestinal tumor screening has reduced incidence and mortality, its treatment faces is hindered by challenges including chemotherapy resistance a...
SNHG5 enhances colorectal cancer metastasis through RNA-protein interaction with GNB2 and activation of canonical Wnt signaling [0.03%]
SNHG5通过与GNB2的RNA-蛋白质相互作用和激活经典Wnt信号通路来增强结直肠癌转移能力
Xinyi Chen,Mu Yang,Xiaoxiao Luo et al.
Xinyi Chen et al.
Background and purpose: Colorectal cancer (CRC) is one of the most prevalent and lethal malignancies worldwide, with distant metastasis-particularly to the liver-representing the primary cause of poor prognosis. Long non-...
Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degeneration via autophagy and ageing in nucleus pulposus cells [0.03%]
表观遗传H3K4me3激活的miR-155-5p通过促进椎间盘细胞自噬和老化来促进椎间盘退变
Ximeng Wang,Hanqiu Sun,Wenbiao Xiao et al.
Ximeng Wang et al.
Nucleus pulposus (NP) cell ageing and impaired autophagy - lysosome biogenesis (ALB) are key drivers of intervertebral disc degeneration (IVDD). The upstream epigenetic regulation of transcription factor EB (TFEB), a major ALB regulator, re...
circ_0103896/miR-432-5p/FTO feedback loop suppresses the formation and progression of intracranial aneurysm [0.03%]
circ_0103896/miR-432-5p/FTO反馈回路抑制颅内动脉瘤的形成和进展
Zhiwen Lu,Shijie Zhu,Yina Wu et al.
Zhiwen Lu et al.
Circular RNAs (circRNAs) and m6A RNA methylation play crucial roles in the pathogenesis of intracranial aneurysm (IA); however, their regulatory interplay remains unclear. Through circRNA profiling of 16 IA tissues and 8 superficial tempora...
The crosstalk network of non-coding RNAs: Emerging opportunities for the clinical application of osteoporosis [0.03%]
非编码RNA的相互作用网络：骨质疏松临床应用的新机遇
Chunlu Yan,Qiao Wan,Zeling Fang et al.
Chunlu Yan et al.
Current methods for testing bone density lack the capability to detect patients with early bone loss, and existing osteoporosis therapies have limitations in their efficacy and safety. Therefore, the development of more precise and convenie...
Investigation of cervical cell image segmentation technology based on deep learning and non-coding RNAs [0.03%]
基于深度学习和非编码RNA的宫颈细胞图像分割技术研究
Cheng Cheng,Yi Yang,Youshan Qu
Cheng Cheng
Background: Cervical cancer remains a significant health concern worldwide, necessitating effective diagnostic methods such as cervical cell image segmentation. This review outlines the challenges and importance of accura...
LncRNA ZFAS1 in hepatocellular carcinoma: A systematic review of molecular mechanisms and clinical translation [0.03%]
长非编码RNA ZFAS1在肝细胞癌中的作用：分子机制和临床转化的系统性综述
Peng Zhu,Hui-Ying Liu
Peng Zhu
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with its high recurrence rate and therapeutic resistance underscoring the urgent need for breakthrough molecular targets. The long non-coding RNA Z...
The progress of m6A methylation-regulated non-coding RNAs in osteogenic differentiation and osteoporosis [0.03%]
m6A甲基化调控的非编码RNA在成骨分化及骨质疏松症中的进展
Yongbin Wang,Baicheng Ma,Jiashuo Qiu et al.
Yongbin Wang et al.
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic RNA, and has increasingly been recognized as a critical regulator of gene expression at both the transcriptional and post-transcriptional levels. The m6A modi...
Circular RNA MALAT1 as a potential target for antimetastatic therapy [0.03%]
环状RNA MALAT1可能是抗转移治疗的潜在靶点
Janusz Matuszyk
Janusz Matuszyk
Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) located in the nucleus that is involved in the regulation of gene expression and alternative splicing of gene transcription products. MALAT1 h...
The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification [0.03%]
circGDI2在m6A修饰参与下的肝癌增殖和糖酵解中的调控作用
Shiyi Chen,Hongxiang Xia,Shuwei Chen
Shiyi Chen
Background: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, and metabolic reprogramming, particularly glycolysis, plays a crucial role in its progression. Circular RNAs (circRNAs) and N6-methyladenosine ...