Serum lncRNAs NEAT1, PVT1 and H19 as novel biomarkers for sarcopenia diagnosis and treatment response [0.03%]
血清长链非编码RNA NEAT1、PVT1和H19作为新的肌少症诊断和治疗反应生物标志物
Paula Aparicio,Tresa López-Royo,David Navarrete-Villanueva et al.
Paula Aparicio et al.
Sarcopenia, the loss of muscle mass and function generally associated to age, leads to increased dependence and mortality in older adults. Despite its clinical significance, unclear molecular mechanisms hinder the development of universal d...
LncRNA levels in the central nervous system as novel potential players and biomarkers in amyotrophic lateral sclerosis [0.03%]
中枢神经系统中长链非编码RNA的水平可作为肌萎缩性侧索硬化的新潜在作用因子和生物标志物
Tresa López-Royo,Laura Moreno-Martínez,Gabriel Rada et al.
Tresa López-Royo et al.
Research in amyotrophic lateral sclerosis (ALS) faces major burdens, including the urgent need for sensitive and specific biomarkers, the identification of novel and effective therapeutic targets and a deeper understanding of the mechanisms...
Deciphering the multifaceted role of circular RNA in aging: from molecular mechanisms to therapeutic potentials [0.03%]
环状RNA在衰老中的作用：从分子机制到治疗潜力
Yang Wang,Cong Wang,Xin Dai et al.
Yang Wang et al.
Aging is an inevitable physiological process that occurs in living organisms and has significant implications for health and disease. As the human lifespan extends, the functionality of organs gradually diminishes, leading to the emergence ...
LncRNA MEG3/CTCF-CXCR4 axis functions in the regulation of breast cancer cell migration [0.03%]
长链非编码RNA MEG3/CTCF-CXCR4轴在乳腺癌细胞迁移中的作用研究
Gusai Elhassan,Xiangxue Bu,Jiaxin Liu et al.
Gusai Elhassan et al.
Loss or decreased expression of lncRNA MEG3 is a frequent event in the progression of many different malignancies. Overexpression of MEG3 in breast cancer cell lines MCF7 or MDA-MB-231 prevented cell migration, whereas depletion of MEG3 in ...
The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications [0.03%]
结直肠癌中微小核糖核酸的多面体作用：发病机制和治疗意义
Federica Longo,Giuseppe Gattuso,Graziana Spoto et al.
Federica Longo et al.
MicroRNAs (miRNAs) are important regulators of gene expression and their dysregulation is involved in various diseases, including tumors. Among these, colorectal cancer (CRC) is the result of both genetic and epigenetic alterations with miR...
Computational discovery of conserved RNA structures and functional characterization of a structured lncRNA in Leishmania braziliensis [0.03%]
利什曼原虫中保守的RNA结构的计算发现和长链非编码RNA功能表征
Caroline R Espada,Christian Anthon,Rubens D M Magalhães et al.
Caroline R Espada et al.
Leishmania parasites alternate between hosts, facing environmental changes that demand rapid gene expression adaptation. Lacking canonical RNA polymerase II promoters, transcription in these eukaryotes is polycistronic, with gene regulation...
Upregulation of LINC02154 promotes esophageal cancer progression by enhancing cell cycling and epithelial-mesenchymal transition [0.03%]
LINC02154上调通过增强细胞周期和上皮间质转化促进食管癌进展
Kotoha Shimote,Takeshi Niinuma,Hiroshi Kitajima et al.
Kotoha Shimote et al.
Long noncoding RNAs (lncRNAs) play crucial roles in the progression of human malignancies; however, their involvement in esophageal cancer (ESCA) remains incompletely understood. In this study, we screened for lncRNAs upregulated in ESCA an...
MicroRNA-29a-5p attenuates hemorrhagic transformation and improves outcomes after mechanical reperfusion for acute ischemic stroke [0.03%]
microRNA-29a-5p可减轻机械性再灌注急性缺血性卒中的出血转化并改善预后
Chang-Luo Li,Jin-Kun Zhuang,Zhong Liu et al.
Chang-Luo Li et al.
Background: Hemorrhage transformation (HT) following endovascular reperfusion treatment is associated with worse clinical outcomes in acute ischemic stroke patients. MicroRNA (miR) modulates several aspects of cerebral is...
USF1-activated hsa_circ_0076691 induces oxaliplatin resistance via facilitating FGF9 expression in miR-589-3p-dependent manners [0.03%]
USF1激活的hsa_circ_0076691通过miR-589-3p依赖方式促进FGF9表达从而诱导奥沙利铂耐药性
Lingyu Tang,Xuan Deng,Ming Guan et al.
Lingyu Tang et al.
Chemotherapeutic efficacy in colorectal cancer (CRC) is significantly hindered by the development of drug resistance. Emerging evidence indicates that circular RNAs (circRNAs) play pivotal roles in various cancer-related biological processe...
LncPTEN1, a long non-coding RNA generated from PTEN, suppresses lung cancer metastasis through the regulation of EMT progress [0.03%]
由PTEN生成的长链非编码RNA LncPTEN1通过调节上皮间质转化进程抑制肺癌转移
Zichu Shen,Ailin Zhong,Chun Zhang et al.
Zichu Shen et al.
Lung cancer is among the most frequently observed and lethal malignancies globally, and metastasis represents a critical determinant of patient outcomes. PTEN, a well-established tumor suppressor, has emerged as an important regulator in lu...